| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moran JH et al. | Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. | 2000 | Toxicol. Appl. Pharmacol. | pmid:11042099 |
| Ha J et al. | Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12127265 |
| Moran JH et al. | Cytotoxicity of linoleic acid diols to renal proximal tubular cells. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9299596 |
| Moran JH et al. | Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11714247 |
| Yu WK and Wells PG | Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878664 |
| Wey HE et al. | Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8511784 |
| Moran JH et al. | Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11298501 |
| Slim R et al. | The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11243918 |
| Matsusue K et al. | A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. | 1997 | Toxicol. Lett. | pmid:9175845 |
| Alghazeer R et al. | Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). | 2008 | Toxicol. Lett. | pmid:18625293 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Mitchell LA et al. | Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. | 2002 | Toxicol. Lett. | pmid:11814707 |
| Montaño M et al. | New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. | 2012 | Toxicol. Sci. | pmid:22859314 |
| Vanden Heuvel JP et al. | Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. | 2006 | Toxicol. Sci. | pmid:16731579 |
| Wang X et al. | From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. | 2018 | Toxicol. Sci. | pmid:29045746 |
| Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
| Sidransky H and Verney E | Toxic effect of valproic acid on tryptophan binding to rat hepatic nuclei. | 1996 | Toxicology | pmid:8619251 |
| Heiskanen K et al. | Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes. | 1995 | Toxicology | pmid:8560489 |
| Ramirez DC and Gimenez MS | Lipid modification in mouse peritoneal macrophages after chronic cadmium exposure. | 2002 | Toxicology | pmid:11844611 |
| Leitch AC et al. | B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. | 2017 | Toxicology | pmid:28552552 |
| Gülçin I | Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). | 2006 | Toxicology | pmid:16243424 |
| Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
| Perez RV et al. | Dietary immunoregulation of transfusion-induced immunosuppression. | 1988 | Transplantation | pmid:3258077 |
| Tchervenkov JI et al. | The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. | 1989 | Transplantation | pmid:2643225 |
| Perez RV et al. | Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid. | 1989 | Transplantation | pmid:2660353 |
| Hansen HS | Linoleic acid as a precursor for acylation of transducin, a retinol G protein? | 1993 | Trends Biochem. Sci. | pmid:8328015 |
| Blée E | Impact of phyto-oxylipins in plant defense. | 2002 | Trends Plant Sci. | pmid:12119169 |
| Nguyen LQ et al. | Intake of essential fatty acids by growing-finishing pigs kept on smallholdings in central Vietnam. | 2005 | Trop Anim Health Prod | pmid:15729898 |
| Rashed MM et al. | Effect of ultrasonic treatment on total phenolic extraction from Lavandula pubescens and its application in palm olein oil industry. | 2016 | Ultrason Sonochem | pmid:26584982 |
| Mikkola JP et al. | Utilisation of on-line acoustic irradiation as a means to counter-effect catalyst deactivation in heterogeneous catalysis. | 2004 | Ultrason Sonochem | pmid:15081987 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Mena J et al. | Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. | 2013 | Vet. Immunol. Immunopathol. | pmid:23267746 |
| Thanasak J et al. | Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. | 2005 | Vet. Immunol. Immunopathol. | pmid:15734550 |
| Plantinga EA et al. | Relationship between the amount of linoleic acid in the diet and that in the adipose tissue of adult cats living freely in households. | 2003 | Vet. Res. Commun. | pmid:14672449 |
| Sasaki T et al. | Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. | 2006 | Virchows Arch. | pmid:16362414 |
| Moon C et al. | Modeling sulfate removal by inhibited mesophilic mixed anaerobic communities using a statistical approach. | 2013 | Water Res. | pmid:23466036 |
| Zheng HF et al. | Effects of unsaturated fatty acids on calcium-activated potassium current in gastric myocytes of guinea pigs. | 2005 | World J. Gastroenterol. | pmid:15655819 |
| Chen BQ et al. | Effects of c9,t11-conjugated linoleic acid on adhesion of human gastric carcinoma cell line SGC-7901. | 2004 | World J. Gastroenterol. | pmid:15133841 |
| Chen BQ et al. | Inhibition of conjugated linoleic acid on mouse forestomach neoplasia induced by benzo (a) pyrene and chemopreventive mechanisms. | 2003 | World J. Gastroenterol. | pmid:12508349 |
| Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
| Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
| Okuyama H et al. | New Cholesterol Guidelines for Longevity (2010). | 2011 | World Rev Nutr Diet | pmid:21865826 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
| Okuyama H et al. | Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? | 2007 | World Rev Nutr Diet | pmid:17167283 |
| Okuyama H et al. | Mechanisms by which dietary fats affect coronary heart disease mortality. | 2007 | World Rev Nutr Diet | pmid:17167284 |
| Okuyama H et al. | Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. | 2007 | World Rev Nutr Diet | pmid:17167285 |
| Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |