| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Seizures | D012640 | 87 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herzberg GR et al. | Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. | 1992 | Biochim. Biophys. Acta | pmid:1531932 |
| Akbiyik F et al. | Ligand- and species-dependent activation of PPARalpha. | 2004 | Cell. Physiol. Biochem. | pmid:15319530 |
| DeWitt C and Bebarta V | Botanical solvents. | 2004 | Clin Occup Environ Med | pmid:15325315 |
| Bazinet RP et al. | Dietary 18:3omega3 influences immune function and the tissue fatty acid response to antigens and adjuvant. | 2004 | Immunol. Lett. | pmid:15325802 |
| Yonezawa T et al. | Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells. | 2004 | J. Dairy Sci. | pmid:15328276 |
| Wilson RA et al. | Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction. | 2004 | Microbiology (Reading, Engl.) | pmid:15347747 |
| Nicolosi RJ et al. | Decreased aortic early atherosclerosis and associated risk factors in hypercholesterolemic hamsters fed a high- or mid-oleic acid oil compared to a high-linoleic acid oil. | 2004 | J. Nutr. Biochem. | pmid:15350986 |
| Pohnert G et al. | Short synthesis of labeled and unlabeled 6Z,9Z,12Z,15-hexadecatetraenoic acid as metabolic probes for biosynthetic studies on diatoms. | 2004 | Chem. Phys. Lipids | pmid:15351268 |
| Momchilova S et al. | Resolution of triacylglycerol positional isomers by reversed-phase high-performance liquid chromatography. | 2004 | J Sep Sci | pmid:15352724 |
| Moore JP et al. | The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation. | 2005 | Biochem. J. | pmid:15355309 |
| Leaf AA et al. | Factors affecting long-chain polyunsaturated fatty acid composition of plasma choline phosphoglycerides in preterm infants. | 1992 | J. Pediatr. Gastroenterol. Nutr. | pmid:1535657 |
| Reiter RJ | Mechanisms of cancer inhibition by melatonin. | 2004 | J. Pineal Res. | pmid:15357667 |
| Caballero MJ et al. | Histological alterations in the liver of sea bream, Sparus aurata L., caused by short- or long-term feeding with vegetable oils. Recovery of normal morphology after feeding fish oil as the sole lipid source. | 2004 | J. Fish Dis. | pmid:15357712 |
| Namazi MR | Further insight into the pathomechanism of acne by considering the 5-alpha-reductase inhibitory effect of linoleic acid. | 2004 | Int. J. Dermatol. | pmid:15357760 |
| Raes K et al. | Effect of diet and dietary fatty acids on the transformation and incorporation of C18 fatty acids in double-muscled Belgian Blue young bulls. | 2004 | J. Agric. Food Chem. | pmid:15366860 |
| Peng S and van der Donk WA | An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase. | 2003 | J. Am. Chem. Soc. | pmid:15369335 |
| Inoue N et al. | Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15369804 |
| Nguyen SD and Sok DE | Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. | 2004 | J. Lipid Res. | pmid:15375178 |
| Qiu X et al. | Effects of substrate, passage rate, and pH in continuous culture on flows of conjugated linoleic acid and trans C18:1. | 2004 | J. Dairy Sci. | pmid:15377625 |
| French S | Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. | 2004 | Br. J. Nutr. | pmid:15384318 |
| Kuo TM and Nakamura LK | Diversity of oleic acid, ricinoleic acid and linoleic acid conversions among Pseudomonas aeruginosa strains. | 2004 | Curr. Microbiol. | pmid:15386114 |
| Kelley RI | Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1540149 |
| pmid:15428914 | ||||
| Fischer SM et al. | Differential effects of dietary linoleic acid on mouse skin-tumor promotion and mammary carcinogenesis. | 1992 | Cancer Res. | pmid:1544140 |
| Lee JH et al. | Feeding encapsulated ground full-fat soybeans to increase polyunsaturated fat concentrations and effects on flavor volatiles in fresh lamb. | 2004 | J. Anim. Sci. | pmid:15446490 |
| Dobson G et al. | Comparison of fatty acid and polar lipid contents of tubers from two potato species, Solanum tuberosum and Solanum phureja. | 2004 | J. Agric. Food Chem. | pmid:15453705 |
| Sundrarjun T et al. | Effects of n-3 fatty acids on serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis factor receptor p55 in active rheumatoid arthritis. | 2004 Sep-Oct | J. Int. Med. Res. | pmid:15458276 |
| Javadi M et al. | The effect of six different C18 fatty acids on body fat and energy metabolism in mice. | 2004 | Br. J. Nutr. | pmid:15469642 |
| Houston M et al. | Oxidized linoleic acid regulates expression and shedding of syndecan-4. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15469957 |
| Ghosh S et al. | Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death. | 2004 | Nutrition | pmid:15474882 |
| Jaburek M et al. | Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2. | 2004 | J. Biol. Chem. | pmid:15475368 |
| Piperova LS et al. | Changes in milk fat in response to dietary supplementation with calcium salts of trans-18:1 or conjugated linoleic fatty acids in lactating dairy cows. | 2004 | J. Dairy Sci. | pmid:15483168 |
| Hargrave KM et al. | Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice. | 2004 | Obes. Res. | pmid:15483208 |
| Valero M and Esteban B | Effect of binary and ternary polyvinylpyrrolidone and/or hydroxypropyl-beta-cyclodextrin complexes on the photochemical and photosensitizing properties of Naproxen. | 2004 | J. Photochem. Photobiol. B, Biol. | pmid:15488720 |
| Downie MM et al. | Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. | 2004 | Br. J. Dermatol. | pmid:15491415 |
| Freeman VL et al. | Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma. | 2004 | Cancer | pmid:15495177 |
| Connolly JM and Rose DP | Interactions between epidermal growth factor-mediated autocrine regulation and linoleic acid-stimulated growth of a human prostate cancer cell line. | 1992 | Prostate | pmid:1549552 |
| Nilsson E and Bengtsson G | Endogenous free fatty acids repel and attract Collembola. | 2004 | J. Chem. Ecol. | pmid:15503529 |
| Baylin A and Campos H | Arachidonic acid in adipose tissue is associated with nonfatal acute myocardial infarction in the central valley of Costa Rica. | 2004 | J. Nutr. | pmid:15514281 |
| Mori TA et al. | Differential effect of aspirin on platelet aggregation in IDDM. | 1992 | Diabetes | pmid:1551486 |
| Egashira Y et al. | Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression. | 2004 | Biochim. Biophys. Acta | pmid:15522828 |
| Elmes M et al. | The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. | 2004 | Biochim. Biophys. Acta | pmid:15522830 |
| Homa ST and Brown CA | Changes in linoleic acid during follicular development and inhibition of spontaneous breakdown of germinal vesicles in cumulus-free bovine oocytes. | 1992 | J. Reprod. Fertil. | pmid:1552477 |
| Rinker KD et al. | Linoleic acid increases monocyte deformation and adhesion to endothelium. | 2004 | Atherosclerosis | pmid:15530900 |
| Jarmuszkiewicz W et al. | Redox state of endogenous coenzyme q modulates the inhibition of linoleic acid-induced uncoupling by guanosine triphosphate in isolated skeletal muscle mitochondria. | 2004 | J. Bioenerg. Biomembr. | pmid:15534396 |
| Miolo G et al. | Photochemistry and phototoxicity of fluocinolone 16,17-acetonide. | 2005 Mar-Apr | Photochem. Photobiol. | pmid:15535735 |
| Scholljegerdes EJ et al. | Influence of supplemental cracked high-linoleate or high-oleate safflower seeds on site and extent of digestion in beef cattle. | 2004 | J. Anim. Sci. | pmid:15537779 |
| Encinias HB et al. | High linoleic acid safflower seed supplementation for gestating ewes: effects on ewe performance, lamb survival, and brown fat stores. | 2004 | J. Anim. Sci. | pmid:15537787 |
| Huang HY et al. | Antioxidant activities of various fruits and vegetables produced in Taiwan. | 2004 | Int J Food Sci Nutr | pmid:15545051 |
| Chang PK et al. | Deletion of the Delta12-oleic acid desaturase gene of a nonaflatoxigenic Aspergillus parasiticus field isolate affects conidiation and sclerotial development. | 2004 | J. Appl. Microbiol. | pmid:15546408 |
| Duffield-Lillico AJ et al. | Can selenium prevent colorectal cancer? A signpost from epidemiology. | 2004 | J. Natl. Cancer Inst. | pmid:15547171 |
| Doderer A et al. | Purification and characterization of two lipoxygenase isoenzymes from germinating barley. | 1992 | Biochim. Biophys. Acta | pmid:1554746 |
| Marongiu B et al. | Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. | 2004 | Phytother Res | pmid:15551397 |
| Yamamoto S et al. | The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancing activity of presynaptic alpha7 acetylcholine receptors on the glutamatergic terminals. | 2005 | Neuroscience | pmid:15561436 |
| Ahn MR et al. | Antioxidant activity and constituents of propolis collected in various areas of Korea. | 2004 | J. Agric. Food Chem. | pmid:15563208 |
| Cury-Boaventura MF and Curi R | Regulation of reactive oxygen species (ROS) production by C18 fatty acids in Jurkat and Raji cells. | 2005 | Clin. Sci. | pmid:15563273 |
| Wen X et al. | Antioxidative activity of a zinc-chelating substance in coffee. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15564670 |
| Diboune M et al. | Composition of phospholipid fatty acids in red blood cell membranes of patients in intensive care units: effects of different intakes of soybean oil, medium-chain triglycerides, and black-currant seed oil. | 1992 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:1556808 |
| Ringseis R et al. | Dietary conjugated linoleic acids lower the triacylglycerol concentration in the milk of lactating rats and impair the growth and increase the mortality of their suckling pups. | 2004 | J. Nutr. | pmid:15570033 |
| Whelan J and McEntee MF | Dietary (n-6) PUFA and intestinal tumorigenesis. | 2004 | J. Nutr. | pmid:15570048 |
| Hussein N et al. | Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. | 2005 | J. Lipid Res. | pmid:15576848 |
| Zhou B et al. | Antioxidative effects of flavonols and their glycosides against the free-radical-induced peroxidation of linoleic acid in solution and in micelles. | 2005 | Chemistry | pmid:15578643 |
| Bonanome A et al. | Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. | 1992 | Arterioscler. Thromb. | pmid:1558840 |
| Zhou B et al. | Evidence for alpha-tocopherol regeneration reaction of green tea polyphenols in SDS micelles. | 2005 | Free Radic. Biol. Med. | pmid:15589374 |
| Javadi M et al. | Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. | 2004 | J. Nutr. Biochem. | pmid:15590272 |
| Burth P et al. | Role of nonesterified unsaturated fatty acids in the pathophysiological processes of leptospiral infection. | 2005 | J. Infect. Dis. | pmid:15593003 |
| Jiang Q et al. | gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15596715 |
| Wang YW et al. | Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. | 2004 | Poult. Sci. | pmid:15615018 |
| Akai K et al. | Ability of ferric nitrilotriacetate complex with three pH-dependent conformations to induce lipid peroxidation. | 2004 | Free Radic. Res. | pmid:15621713 |
| Edwards IJ et al. | Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin. | 2004 | Clin. Cancer Res. | pmid:15623603 |
| Nagao K et al. | Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. | 2005 | J. Nutr. | pmid:15623825 |
| Ye P et al. | [An exploratory study on mechanism of PPARalpha activators-induced plasminogen activator inhibitor-1 expression in HepG-2 cells]. | 2004 | Zhonghua Nei Ke Za Zhi | pmid:15631825 |
| Wu MJ et al. | Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). | 2004 | Am. J. Chin. Med. | pmid:15633804 |
| Lalush I et al. | Utilization of amylose-lipid complexes as molecular nanocapsules for conjugated linoleic Acid. | 2005 Jan-Feb | Biomacromolecules | pmid:15638512 |
| Mishra R and Simonson MS | Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G. | 2005 | Cardiovasc Diabetol | pmid:15642122 |
| Cheng Z et al. | The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes. | 2005 | J. Endocrinol. | pmid:15642793 |
| Nagai T et al. | Antioxidative ability in a linoleic acid oxidation system and scavenging abilities against active oxygen species of enzymatic hydrolysates from pollen Cistus ladaniferus. | 2005 | Int. J. Mol. Med. | pmid:15647841 |
| Mensink RP | Metabolic and health effects of isomeric fatty acids. | 2005 | Curr. Opin. Lipidol. | pmid:15650560 |
| Loor JJ et al. | Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. | 2005 | J. Dairy Sci. | pmid:15653539 |
| Schmidely P et al. | Influence of extruded soybeans with or without bicarbonate on milk performance and fatty acid composition of goat milk. | 2005 | J. Dairy Sci. | pmid:15653542 |
| Djoussé L et al. | Dietary linolenic acid is associated with a lower prevalence of hypertension in the NHLBI Family Heart Study. | 2005 | Hypertension | pmid:15655119 |
| Zheng HF et al. | Effects of unsaturated fatty acids on calcium-activated potassium current in gastric myocytes of guinea pigs. | 2005 | World J. Gastroenterol. | pmid:15655819 |
| Muangman P et al. | Antioxidants inhibit fatty acid and glucose-mediated induction of neutral endopeptidase gene expression in human microvascular endothelial cells. | 2005 | J. Am. Coll. Surg. | pmid:15664096 |
| Laaksonen DE et al. | Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. | 2005 | Arch. Intern. Med. | pmid:15668366 |
| Meyskens FL et al. | Diet and melanoma in a case-control study. | 2005 | Cancer Epidemiol. Biomarkers Prev. | pmid:15668513 |
| Brightman AO et al. | A growth factor- and hormone-stimulated NADH oxidase from rat liver plasma membrane. | 1992 | Biochim. Biophys. Acta | pmid:1567890 |
| Belkner J et al. | Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15681297 |
| Taylor EN et al. | Fatty acid intake and incident nephrolithiasis. | 2005 | Am. J. Kidney Dis. | pmid:15685503 |
| Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
| Mendis E et al. | Antioxidant properties of a radical-scavenging peptide purified from enzymatically prepared fish skin gelatin hydrolysate. | 2005 | J. Agric. Food Chem. | pmid:15686405 |
| Zock PL and Katan MB | Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. | 1992 | J. Lipid Res. | pmid:1569387 |
| Cantwell MM et al. | Development and validation of a food-frequency questionnaire for the determination of detailed fatty acid intakes. | 2005 | Public Health Nutr | pmid:15705250 |
| Daoud G et al. | Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. | 2005 | Biochim. Biophys. Acta | pmid:15708366 |
| Yaguchi T et al. | Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710250 |
| Pakdeechanuan P et al. | Effects of rhodium heterogeneous catalyst and isomerization conditions on linoleic acid conjugation of soybean oil. | 2005 | J. Agric. Food Chem. | pmid:15712999 |
| MacKenzie SE et al. | Isolation of sterols from the marine fungus Corollospora lacera. | 2004 | Can. J. Microbiol. | pmid:15714238 |
| Lane ME et al. | Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. | 2005 | J. Pharm. Pharmacol. | pmid:15720779 |
| Kelavkar UP et al. | Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice. | 2004 Nov-Dec | Neoplasia | pmid:15720809 |
| Kapich AN et al. | A rapid method to quantify pro-oxidant activity in cultures of wood-decaying white-rot fungi. | 2005 | J. Microbiol. Methods | pmid:15722153 |
| Nguyen LQ et al. | Intake of essential fatty acids by growing-finishing pigs kept on smallholdings in central Vietnam. | 2005 | Trop Anim Health Prod | pmid:15729898 |