| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Seizures | D012640 | 87 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
| Lomnitski L et al. | The interaction between beta-carotene and lipoxygenase in plant and animal systems. | 1993 | Biochim. Biophys. Acta | pmid:8481396 |
| Sunzeri FJ and Buehring GC | Lipids alter the level and distribution of mouse mammary tumor virus gp52 in vitro. | 1993 | Cancer Lett. | pmid:8287372 |
| Sud'ina GF et al. | Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | 1993 | FEBS Lett. | pmid:7689063 |
| Hansen HS | Linoleic acid as a precursor for acylation of transducin, a retinol G protein? | 1993 | Trends Biochem. Sci. | pmid:8328015 |
| Vargas F et al. | Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. | 1993 | Photochem. Photobiol. | pmid:8248320 |
| Mao-Qiang M et al. | Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. | 1993 | J. Invest. Dermatol. | pmid:8345219 |
| Rabinowitch HD et al. | Escherichia coli produces linoleic acid during late stationary phase. | 1993 | J. Bacteriol. | pmid:8366020 |
| Jones AL et al. | Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8250841 |
| Band AM et al. | The mechanism of arachidonic acid-induced insulin secretion from rat islets of Langerhans. | 1993 | Biochim. Biophys. Acta | pmid:8452880 |
| Vaughan PF et al. | Effect of inhibitors of eicosanoid metabolism on release of [3H]noradrenaline from the human neuroblastoma, SH-SY5Y. | 1993 | J. Neurochem. | pmid:8455030 |
| Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
| Viola G et al. | Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. | 1993 | J. Lipid Res. | pmid:8263409 |
| Grech ED et al. | Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. | 1993 | Coron. Artery Dis. | pmid:8287210 |
| van Haaster CM et al. | Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat. | 1993 | Biochim. Biophys. Acta | pmid:8466942 |
| Marcelo CL and Dunham WR | Fatty acid metabolism studies of human epidermal cell cultures. | 1993 | J. Lipid Res. | pmid:8301228 |
| Hernell O et al. | Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids? | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8315552 |
| Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
| Hatala MA et al. | Characterization of phospholipase A2 activity in MDA-MB-435 human breast cancer cells. | 1993 | Cancer Lett. | pmid:8402571 |
| Markovic DZ and Patterson LK | Benzophenone-sensitized lipid peroxidation in linoleate micelles. | 1993 | Photochem. Photobiol. | pmid:8234464 |
| Sugano M and Koba K | Dietary protein and lipid metabolism: a multifunctional effect. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8489133 |
| James MJ et al. | Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8379505 |
| Sigurdson SL and Ip MM | Casein accumulation by rat mammary epithelial cells grown within a reconstituted basement membrane is modulated by fatty acids in a hormone- and time-dependent manner. | 1993 | Exp. Cell Res. | pmid:8375465 |
| Feunekes GI et al. | Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. | 1993 | Am. J. Clin. Nutr. | pmid:8379504 |
| Laihia JK et al. | Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity. | 1993 | Free Radic. Biol. Med. | pmid:8394267 |
| Reid G | Metabolic disorders of cattle. | 1993 | Med. Hypotheses | pmid:8394500 |
| Davis PA et al. | A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. | 1993 | Ann. Intern. Med. | pmid:8363165 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| Biagi PL et al. | Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. | 1993 | Acta Paediatr. | pmid:8241678 |
| Soliven B et al. | Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. | 1993 | Am. J. Physiol. | pmid:8384786 |
| Chang WC et al. | Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells. | 1993 | J. Biol. Chem. | pmid:8360167 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Daret D et al. | Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. | 1993 | J. Lipid Res. | pmid:8228632 |
| Kleinveld HA et al. | Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ratio of oleic acid content to linoleic acid content: studies in vitamin E deficient subjects. | 1993 | Free Radic. Biol. Med. | pmid:8406127 |
| Keler T and Sorof S | Growth promotion of transfected hepatoma cells by liver fatty acid binding protein. | 1993 | J. Cell. Physiol. | pmid:8408240 |
| Jenkins TC et al. | Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. | 1994 | J. Nutr. | pmid:8145079 |
| Rao SI et al. | The lipoxygenase activity of myoglobin. Oxidation of linoleic acid by the ferryl oxygen rather than protein radical. | 1994 | J. Biol. Chem. | pmid:8125933 |
| Castell JV et al. | Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. | 1994 | Photochem. Photobiol. | pmid:8127938 |
| Grammatopoulos D et al. | The human myometrial CRH receptor: G proteins and second messengers. | 1994 | Mol. Cell. Endocrinol. | pmid:8206332 |
| Fuchs GJ et al. | Effect of dietary fat on cardiovascular risk factors in infancy. | 1994 | Pediatrics | pmid:8165074 |
| Cho Y and Ziboh VA | Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. | 1994 | J. Lipid Res. | pmid:8169529 |
| Shi X et al. | Silica radical-induced DNA damage and lipid peroxidation. | 1994 | Environ. Health Perspect. | pmid:7705289 |
| Glasgow WC and Eling TE | Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8203891 |
| Kvilekval K et al. | Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. | 1994 | J. Lipid Res. | pmid:7852855 |
| Hrboticky N et al. | Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. | 1994 | J. Clin. Invest. | pmid:8282787 |
| Jones RE | A hypothesis for early intervention in SIDS. | 1994 | Clin Pediatr (Phila) | pmid:7813148 |
| Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
| Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
| Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
| Yamashiro Y et al. | Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8201513 |
| Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
| Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
| Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
| Yamamoto A et al. | Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. | 1994 | J. Pharm. Pharmacol. | pmid:7515417 |
| Luthria DL and Sprecher H | A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. | 1994 | Biochim. Biophys. Acta | pmid:8011670 |
| Woldseth B and Christophersen BO | Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. | 1994 | Biochim. Biophys. Acta | pmid:8011678 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Bulan EJ et al. | Immature maxi-K channels exhibit heterogeneous properties in the embryonic rat telencephalon. | 1994 | Dev. Neurosci. | pmid:7867514 |
| Hussey HJ and Tisdale MJ | Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. | 1994 | Br. J. Cancer | pmid:8018542 |
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| Simopoulos AP | Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? | 1994 | Free Radic. Biol. Med. | pmid:8001841 |
| Batna A and Spiteller G | Oxidation of furan fatty acids by soybean lipoxygenase-1 in the presence of linoleic acid. | 1994 | Chem. Phys. Lipids | pmid:8033289 |
| Imokawa G et al. | Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia. | 1994 | J. Clin. Invest. | pmid:8040295 |
| Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
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| Eder K and Kirchgessner M | Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. | 1994 | J. Nutr. | pmid:7931700 |
| Ohrvall M et al. | Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. | 1994 | Atherosclerosis | pmid:7980703 |
| Lee KN et al. | Conjugated linoleic acid and atherosclerosis in rabbits. | 1994 | Atherosclerosis | pmid:7980704 |
| Yam D et al. | Insulin and glucose status, tissue and plasma lipids in patients with tumours of the ovary or endometrium: possible dietary implications. | 1994 | Br. J. Cancer | pmid:7981074 |
| Hamberg M et al. | Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. | 1994 | Arch. Biochem. Biophys. | pmid:8117115 |
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| Paiement J et al. | Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. | 1994 | Biochim. Biophys. Acta | pmid:8142417 |
| Pronczuk A et al. | Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. | 1994 | FASEB J. | pmid:7958627 |
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| Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Jakobsen K et al. | Heat production and quantitative oxidation of nutrients by physical activity in pigs. | 1994 | Ann. Nutr. Metab. | pmid:8185282 |
| Cronan JE and Rock CO | The presence of linoleic acid in Escherichia coli cannot be confirmed. | 1994 | J. Bacteriol. | pmid:8188608 |