| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Seizures | D012640 | 87 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kiliç T et al. | Fatty acid composition of seeds of some species of Nepeta L. | 2007 | Nat. Prod. Res. | pmid:17487620 |
| Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
| Scholljegerdes EJ et al. | Fatty acid composition of plasma, medial basal hypothalamus, and uterine tissue in primiparous beef cows fed high-linoleate safflower seeds. | 2007 | J. Anim. Sci. | pmid:17325123 |
| Segovia-Siapco G et al. | Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. | 2007 | Public Health Nutr | pmid:17261227 |
| Shen SR et al. | Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. | 2007 | Mol Nutr Food Res | pmid:17262883 |
| Zhu X and Sayre LM | Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. | 2007 | Redox Rep. | pmid:17263908 |
| Yano M et al. | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. | 2007 | Antimicrob. Agents Chemother. | pmid:17420205 |
| Ringseis R et al. | Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver. | 2007 | J. Nutr. | pmid:17182804 |
| Ben-Shabat S et al. | Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. | 2007 | Drug Dev Ind Pharm | pmid:18058312 |
| Yuan S and Chang SK | Selected odor compounds in soymilk as affected by chemical composition and lipoxygenases in five soybean materials. | 2007 | J. Agric. Food Chem. | pmid:17227075 |
| Griel AE et al. | An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. | 2007 | Nutr J | pmid:17227589 |
| Markaverich BM et al. | Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. | 2007 | Environ. Health Perspect. | pmid:18087590 |
| Golfetto I et al. | Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? | 2007 | Nutr Health | pmid:18087864 |
| Clément M et al. | Whey-derived free fatty acids suppress the germination of Candida albicans in vitro. | 2007 | FEMS Yeast Res. | pmid:17034417 |
| Gülçin I et al. | Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. | 2007 | Phytother Res | pmid:17221941 |
| Somparn P et al. | Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. | 2007 | Biol. Pharm. Bull. | pmid:17202663 |
| Yazdanparast R and Ardestani A | In vitro antioxidant and free radical scavenging activity of Cyperus rotundus. | 2007 | J Med Food | pmid:18158839 |
| Güllçin I and Daştan A | Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. | 2007 | J Enzyme Inhib Med Chem | pmid:18237020 |
| Lin YH and Salem N | Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. | 2007 | J. Lipid Res. | pmid:17876057 |
| LaRosa PC et al. | Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. | 2007 | Physiol. Genomics | pmid:17878318 |
| You Y et al. | Identification of major phenolic compounds of Chinese water chestnut and their antioxidant activity. | 2007 | Molecules | pmid:17851436 |
| Goupy P et al. | Dietary antioxidants as inhibitors of the heme-induced peroxidation of linoleic acid: mechanism of action and synergism. | 2007 | Free Radic. Biol. Med. | pmid:17697938 |
| Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
| Yuri M et al. | Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. | 2007 | Histopathology | pmid:17711445 |
| Breiden B et al. | Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides. | 2007 | Eur. J. Cell Biol. | pmid:17714827 |
| Shyamala BN et al. | Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. | 2007 | J. Agric. Food Chem. | pmid:17715988 |
| Polesel J et al. | Nutrients intake and the risk of hepatocellular carcinoma in Italy. | 2007 | Eur. J. Cancer | pmid:17719221 |
| Koto T et al. | Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. | 2007 | Invest. Ophthalmol. Vis. Sci. | pmid:17724224 |
| Barrett E et al. | Rapid screening method for analyzing the conjugated linoleic acid production capabilities of bacterial cultures. | 2007 | Appl. Environ. Microbiol. | pmid:17277221 |
| Breza JM et al. | Monosodium glutamate but not linoleic acid differentially activates gustatory neurons in the rat geniculate ganglion. | 2007 | Chem. Senses | pmid:17693416 |
| Nam JW and Kappock TJ | Cloning and transcriptional analysis of Crepis alpina fatty acid desaturases affecting the biosynthesis of crepenynic acid. | 2007 | J. Exp. Bot. | pmid:17329262 |
| Fang IM et al. | Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cells. | 2007 | Exp. Eye Res. | pmid:17825288 |
| Shah M et al. | Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. | 2007 | Diabetes Care | pmid:17804680 |
| Walkowiak J et al. | Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:18030219 |
| Zhang JS et al. | [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway]. | 2007 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18399127 |
| Nam IS and Garnsworthy PC | Factors influencing biohydrogenation and conjugated linoleic acid production by mixed rumen fungi. | 2007 | J. Microbiol. | pmid:17618224 |
| Bu DP et al. | Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows. | 2007 | J. Dairy Sci. | pmid:17235178 |
| Szachowicz-Petelska B et al. | Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. | 2007 | Mol. Cell. Biochem. | pmid:16858511 |
| Thomas EA and Yao JK | Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D. | 2007 | Schizophr. Res. | pmid:17011169 |
| Matta JA et al. | TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. | 2007 | J. Physiol. (Lond.) | pmid:17038422 |
| Tarnopolsky M et al. | Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. | 2007 | PLoS ONE | pmid:17912368 |
| Fujiyama Y et al. | Butter feeding enhances TNF-alpha production from macrophages and lymphocyte adherence in murine small intestinal microvessels. | 2007 | J. Gastroenterol. Hepatol. | pmid:17914958 |
| Gakwaya R et al. | Examining the collision-induced decomposition spectra of ammoniated triglycerides. III. The linoleate and arachidonate series. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17893948 |
| Wallace RJ et al. | Isomers of conjugated linoleic acids are synthesized via different mechanisms in ruminal digesta and bacteria. | 2007 | J. Lipid Res. | pmid:17644775 |
| Ben Bacha A et al. | Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. | 2007 | Pancreas | pmid:17895836 |
| Maia MR et al. | Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. | 2007 | Antonie Van Leeuwenhoek | pmid:17072533 |
| Tunalier Z et al. | Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts. | 2007 | J Ethnopharmacol | pmid:17125946 |
| Cosgrove MC et al. | Dietary nutrient intakes and skin-aging appearance among middle-aged American women. | 2007 | Am. J. Clin. Nutr. | pmid:17921406 |
| Ito T et al. | The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. | 2007 | Plant Cell | pmid:17981996 |
| Balesteros MR et al. | Determination of olive oil acidity by CE. | 2007 | Electrophoresis | pmid:17941122 |
| Takajo T et al. | Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid. | 2007 | J. Lipid Res. | pmid:17337722 |
| Hamam F and Shahidi F | Acidolysis of tristearin with selected long-chain fatty acids. | 2007 | J. Agric. Food Chem. | pmid:17288439 |
| Mattes RD | Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17290007 |
| Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
| Degner SC et al. | Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. | 2007 | Nutr Cancer | pmid:18001219 |
| Ou L et al. | Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17400188 |
| Liou YA et al. | Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. | 2007 | J. Nutr. | pmid:17374659 |
| Koeduka T et al. | Cloning of lipoxygenase genes from a cyanobacterium, Nostoc punctiforme, and its expression in Eschelichia coli. | 2007 | Curr. Microbiol. | pmid:17375360 |
| Mizushina Y et al. | Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. | 2007 | Biochimie | pmid:17383068 |
| Makrantonaki E and Zouboulis CC | Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. | 2007 | Br. J. Dermatol. | pmid:17300229 |
| Zhu X and Sayre LM | Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides. | 2007 | Chem. Res. Toxicol. | pmid:17305402 |
| Mukherjee A et al. | Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. | 2007 | Biochemistry | pmid:17355126 |
| Romero MM et al. | The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17387456 |
| Ander BP et al. | Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. | 2007 | Cardiovasc. Res. | pmid:17059813 |
| Forsythe CE et al. | Cholesterolaemic influence of palmitic acid in the sn-1, 3 v. the sn-2 position with high or low dietary linoleic acid in healthy young men. | 2007 | Br. J. Nutr. | pmid:17391563 |
| Pankiewicz E et al. | Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section. | 2007 | Early Hum. Dev. | pmid:17059872 |
| Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
| Makena P and Chung KT | Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species. | 2007 | Environ. Mol. Mutagen. | pmid:17370336 |
| Ay M et al. | Antioxidant activity of Erica arborea. | 2007 | Fitoterapia | pmid:17570611 |
| Chalé-Rush A et al. | Multiple routes of chemosensitivity to free fatty acids in humans. | 2007 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17234892 |
| Maduko CO et al. | Enzymatic interesterification of tripalmitin with vegetable oil blends for formulation of caprine milk infant formula analogs. | 2007 | J. Dairy Sci. | pmid:17235135 |
| Ghezzi S et al. | Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. | 2007 | Lipids | pmid:17551762 |
| Vargas F et al. | Photodegradation and in vitro phototoxicity of aceclofenac. | 2007 | Pharmazie | pmid:17557739 |
| Cazzolli R et al. | Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. | 2007 | Diabetologia | pmid:17593346 |
| Lauretani F et al. | Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. | 2007 | Eur. J. Neurol. | pmid:17594339 |
| Kolar SS et al. | Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. | 2007 | Cancer Res. | pmid:17545640 |
| Kuipers RS et al. | Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17383169 |
| Bondia-Pons I et al. | Determination of conjugated linoleic acid in human plasma by fast gas chromatography. | 2007 | J Chromatogr A | pmid:17532324 |
| Ren Y et al. | Preparation of liquid-core nanocapsules from poly[(ethylene oxide)-co-glycidol] with multiple hydrophobic linoleates at an oil-water interface and its encapsulation of pyrene. | 2007 | Biomacromolecules | pmid:17518441 |
| Guo W et al. | Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17519282 |
| Fang Q et al. | Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific. | 2007 | Mutat. Res. | pmid:17521682 |
| Barla A et al. | Screening of antioxidant activity of three Euphorbia species from Turkey. | 2007 | Fitoterapia | pmid:17582698 |
| Tejero I et al. | A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1. | 2007 | J Comput Chem | pmid:17274015 |
| Sun CH et al. | [Effects of conjugated linoleic acid on expression of GLUT4 protein in skeletal muscle of insulin resistant rat]. | 2007 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:17484206 |
| Egashira Y et al. | Dietary protein level and dietary interaction affect quinolinic acid concentration in rats. | 2007 | Int J Vitam Nutr Res | pmid:17896587 |
| Yin D et al. | Construction of a high-efficient expression vector of Delta12 fatty acid desaturase in peanut and its prokaryotical expression. | 2007 | J Genet Genomics | pmid:17469780 |
| Bongers ME et al. | The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. | 2007 | Nutr J | pmid:17428343 |
| Subauste AR and Burant CF | Role of FoxO1 in FFA-induced oxidative stress in adipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17374693 |
| Tanaka T et al. | Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. | 2007 | FEBS J. | pmid:17451430 |
| Van Nieuwenhove CP et al. | Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. | 2007 | Lett. Appl. Microbiol. | pmid:17451511 |
| Kim JH et al. | Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. | 2007 | Poult. Sci. | pmid:17495090 |
| Li Z et al. | Lipase-catalyzed esterification of conjugated linoleic acid with L-carnitine in solvent-free system and acetonitrile. | 2007 | Bioprocess Biosyst Eng | pmid:17503088 |
| Sankaran D et al. | COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. | 2007 | J. Nutr. Biochem. | pmid:17475460 |
| Bozzo F et al. | Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. | 2007 | Chem. Biol. Interact. | pmid:17632092 |
| Gorjão R et al. | Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. | 2007 | J. Lipid Res. | pmid:17592174 |
| Kumar S et al. | Antioxidant profile of ethoxyquin and some of its S, Se, and Te analogues. | 2007 | J. Org. Chem. | pmid:17602530 |
| Dufour C et al. | Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. | 2007 | Free Radic. Biol. Med. | pmid:17603933 |
| Altmann R et al. | 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. | 2007 | Biochem. Pharmacol. | pmid:17604003 |
| Zeng YX et al. | Comparative analysis of volatile components from Clematis species growing in China. | 2007 | Anal. Chim. Acta | pmid:17606017 |
| Hodge AM et al. | Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. | 2007 | Am. J. Clin. Nutr. | pmid:17616780 |