| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Seizures | D012640 | 87 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thanasak J et al. | Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. | 2005 | Vet. Immunol. Immunopathol. | pmid:15734550 |
| Lee SH et al. | Analysis of FeII-mediated decomposition of a linoleic acid-derived lipid hydroperoxide by liquid chromatography/mass spectrometry. | 2005 | J Mass Spectrom | pmid:15739161 |
| Delgado-Andrade C and Morales FJ | Unraveling the contribution of melanoidins to the antioxidant activity of coffee brews. | 2005 | J. Agric. Food Chem. | pmid:15740014 |
| Salas JJ et al. | Impact of the suppression of lipoxygenase and hydroperoxide lyase on the quality of the green odor in green leaves. | 2005 | J. Agric. Food Chem. | pmid:15740054 |
| Mitmesser SH and Carr TP | Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells. | 2005 | J. Nutr. Biochem. | pmid:15741053 |
| Gülçin I et al. | Determination of in vitro antioxidant and radical scavenging activities of propofol. | 2005 | Chem. Pharm. Bull. | pmid:15744098 |
| Araseki M et al. | Lipid peroxidation of a human hepatoma cell line (HepG2) after incorporation of linoleic acid, arachidonic acid, and docosahexaenoic acid. | 2005 | Biosci. Biotechnol. Biochem. | pmid:15784975 |
| Montalti D et al. | The chemical composition of the uropygial gland secretion of rock dove Columba livia. | 2005 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:15792592 |
| Cury-Boaventura MF et al. | Comparative toxicity of oleic acid and linoleic acid on Raji cells. | 2005 | Nutrition | pmid:15797684 |
| Cui Y et al. | Potential biomedical properties of Pinus massoniana bark extract. | 2005 | Phytother Res | pmid:15798999 |
| Ghafoorunissa A et al. | Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. | 2005 | Biochim. Biophys. Acta | pmid:15801047 |
| Vidal-Mas J et al. | Cloning and expression of a lipoxygenase from Pseudomonas aeruginosa 42A2. | 2005 | Antonie Van Leeuwenhoek | pmid:15803390 |
| Sokmen M et al. | In vitro antioxidant activity of polyphenol extracts with antiviral properties from Geranium sanguineum L. | 2005 | Life Sci. | pmid:15820508 |
| Hassimotto NM et al. | Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. | 2005 | J. Agric. Food Chem. | pmid:15826041 |
| Nugent AP et al. | The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. | 2005 | Eur J Clin Nutr | pmid:15827560 |
| Salem ML | Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of TH1 cytokines. | 2005 | Int. Immunopharmacol. | pmid:15829411 |
| Kim HJ et al. | A model for research on the blood-brain barrier disruption induced by unsaturated fatty acid emulsion. | 2005 | Invest Radiol | pmid:15829824 |
| Yuan YV et al. | Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. | 2005 | Food Chem. Toxicol. | pmid:15833383 |
| Goyens PL et al. | Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses. | 2005 | J. Lipid Res. | pmid:15834128 |
| Sakai H and Kajiwara S | Cloning and functional characterization of a Delta12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. | 2005 | Mol. Genet. Genomics | pmid:15838640 |
| Lapidot T et al. | Lipid hydroperoxidase activity of myoglobin and phenolic antioxidants in simulated gastric fluid. | 2005 | J. Agric. Food Chem. | pmid:15853377 |
| Pérez-Gilabert M et al. | Purification and partial characterization of lipoxygenase from desert truffle (Terfezia claveryi Chatin) ascocarps. | 2005 | J. Agric. Food Chem. | pmid:15853417 |
| Lucchi L et al. | Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients. | 2005 | Artif Organs | pmid:15854218 |
| Maingrette F and Renier G | Linoleic acid increases lectin-like oxidized LDL receptor-1 (LOX-1) expression in human aortic endothelial cells. | 2005 | Diabetes | pmid:15855339 |
| Madigan C et al. | Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes. | 2005 Jan-Mar | Ir J Med Sci | pmid:15868884 |
| Kitaguchi H et al. | Direct ESR detection of pentadienyl radicals and peroxyl radicals in lipid peroxidation: mechanistic insight into regioselective oxygenation in lipoxygenases. | 2005 | J. Am. Chem. Soc. | pmid:15869281 |
| Glasgow WC et al. | Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. | 1992 | J. Biol. Chem. | pmid:1587852 |
| Yeh CS et al. | Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. | 2006 | Cancer Lett. | pmid:15885896 |
| Hristov AN et al. | Effect of diets containing linoleic acid- or oleic acid-rich oils on ruminal fermentation and nutrient digestibility, and performance and fatty acid composition of adipose and muscle tissues of finishing cattle. | 2005 | J. Anim. Sci. | pmid:15890808 |
| Lee KU et al. | Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. | 2005 | Circ. Res. | pmid:15905464 |
| Jarmuszkiewicz W et al. | In phosphorylating Acanthamoeba castellanii mitochondria the sensitivity of uncoupling protein activity to GTP depends on the redox state of quinone. | 2005 | J. Bioenerg. Biomembr. | pmid:15906155 |
| Ha TJ and Kubo I | Lipoxygenase inhibitory activity of anacardic acids. | 2005 | J. Agric. Food Chem. | pmid:15913294 |
| Lin YH et al. | Simultaneous quantitative determination of deuterium- and carbon-13-labeled essential fatty acids in rat plasma. | 2005 | J. Lipid Res. | pmid:15930513 |
| Lin YH and Salem N | In vivo conversion of 18- and 20-C essential fatty acids in rats using the multiple simultaneous stable isotope method. | 2005 | J. Lipid Res. | pmid:15930514 |
| Yin F et al. | Direct electrochemistry of hemoglobin immobilized on gold electrode by Langmuir-Blodgett technique. | 2005 | Biosens Bioelectron | pmid:15935633 |
| Wenli Y and Yaping Z | Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. | 2005 | Biochim. Biophys. Acta | pmid:15936152 |
| Garfinkel M et al. | Insulinotropic potency of lauric acid: a metabolic rationale for medium chain fatty acids (MCF) in TPN formulation. | 1992 | J. Surg. Res. | pmid:1593871 |
| Tsao R et al. | Which polyphenolic compounds contribute to the total antioxidant activities of apple? | 2005 | J. Agric. Food Chem. | pmid:15941346 |
| Fukuda S et al. | A new strain of Butyrivibrio fibrisolvens that has high ability to isomerize linoleic acid to conjugated linoleic acid. | 2005 | J. Gen. Appl. Microbiol. | pmid:15942871 |
| Keler T et al. | Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1594582 |
| Kashfi K and Rigas B | Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. | 2005 | Biochem. Pharmacol. | pmid:15949789 |
| Kisidayová S et al. | Regeneration of cryoresistance of in vitro rumen ciliate cultures. | 2005 | Cryobiology | pmid:15950963 |
| van Himbergen TM et al. | Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15963464 |
| Salem N et al. | Incomplete replacement of docosahexaenoic acid by n-6 docosapentaenoic acid in the rat retina after an n-3 fatty acid deficient diet. | 2005 | Exp. Eye Res. | pmid:15967432 |
| Iwamoto KS et al. | Linoleate produces remission in canine mycosis fungoides. | 1992 | Cancer Lett. | pmid:1596872 |
| Puthpongsiriporn U and Scheideler SE | Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. | 2005 | Poult. Sci. | pmid:15971520 |
| Ng Y et al. | The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. | 2005 | Carcinogenesis | pmid:15975958 |
| Mekhloufi J et al. | Antioxidant activity of melatonin and a pinoline derivative on linoleate model system. | 2005 | J. Pineal Res. | pmid:15978054 |
| Huang R et al. | Factors affecting the free radical scavenging behavior of chitosan sulfate. | 2005 | Int. J. Biol. Macromol. | pmid:15979138 |
| Reis A et al. | Identification of linoleic acid free radicals and other breakdown products using spin trapping with liquid chromatography-electrospray tandem mass spectrometry. | 2006 | Biomed. Chromatogr. | pmid:15981198 |
| Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
| Uden S et al. | Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. | 1992 | Aliment. Pharmacol. Ther. | pmid:1600043 |
| Jung KC et al. | Determination of the dissociation constants for recombinant c-Myc, Max, and DNA complexes: the inhibitory effect of linoleic acid on the DNA-binding step. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16002048 |
| Serezani CH et al. | Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. | 2005 | J. Leukoc. Biol. | pmid:16006535 |
| Di Mascio P et al. | Are dioxetanes chemiluminescent intermediates in lipoperoxidation? | 1992 | Free Radic. Biol. Med. | pmid:1601322 |
| Villasuso AL et al. | Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. | 2005 | Biochim. Biophys. Acta | pmid:16024291 |
| Pérez-Gilabert M et al. | Kinetic properties of lipoxygenase from desert truffle (Terfezia claveryi Chatin) ascocarps: effect of inhibitors and activators. | 2005 | J. Agric. Food Chem. | pmid:16029008 |
| Vulcain E et al. | Inhibition of the metmyoglobin-induced peroxidation of linoleic acid by dietary antioxidants: Action in the aqueous vs. lipid phase. | 2005 | Free Radic. Res. | pmid:16036331 |
| Salehi A et al. | Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion. | 2005 | Cell Tissue Res. | pmid:16044321 |
| Heinemann KM et al. | Long-chain (n-3) polyunsaturated fatty acids are more efficient than alpha-linolenic acid in improving electroretinogram responses of puppies exposed during gestation, lactation, and weaning. | 2005 | J. Nutr. | pmid:16046723 |
| Chaitidis P et al. | Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines. | 2005 | Med. Sci. Monit. | pmid:16049371 |
| Yang XB et al. | Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. | 2005 | Biochim. Biophys. Acta | pmid:16054758 |
| de Roos B et al. | Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. | 2005 | FASEB J. | pmid:16055499 |
| Garg ML et al. | Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. | 1992 | Biochim. Biophys. Acta | pmid:1606171 |
| Li G et al. | 10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo. | 2005 | J. Lipid Res. | pmid:16061956 |
| Lee JH et al. | Enhancing alpha-tocopherol and linoleic acid in ewe's milk by feeding emulsified sunflower oil and DL-alpha-tocopheryl acetate in a chemically treated protein matrix. | 2005 | J. Agric. Food Chem. | pmid:16076135 |
| Nohl H et al. | Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone. | 2005 Jul-Aug | Anticancer Res. | pmid:16080529 |
| Sato I et al. | Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds. | 2005 | J. Vet. Med. Sci. | pmid:16082125 |
| Mathew S and Abraham TE | In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies. | 2006 | Food Chem. Toxicol. | pmid:16087283 |
| Moffitt JH et al. | Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. | 2005 | Diabetologia | pmid:16094531 |
| Sasaki T et al. | Inhibitory effect of linoleic acid on transformation of IEC6 intestinal cells by in vitro azoxymethane treatment. | 2006 | Int. J. Cancer | pmid:16094650 |
| Armoni M et al. | Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements. | 2005 | J. Biol. Chem. | pmid:16096283 |
| Hou CT et al. | Evaluation of microbial strains for linoleic acid hydroxylation and reclassification of strain ALA2. | 2005 | Antonie Van Leeuwenhoek | pmid:16096693 |
| Rioux FM and Innis SM | Arachidonic acid concentrations in plasma and liver phospholipid and cholesterol esters of piglets raised on formulas with different linoleic and linolenic acid contents. | 1992 | Am. J. Clin. Nutr. | pmid:1609747 |
| Trommer H et al. | Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure. | 2005 | J. Pharm. Pharmacol. | pmid:16102251 |
| Kawashima Y et al. | Reduction by clofibric acid of serum arachidonic acid in rats. Effect on the acyl composition of renal phospholipids. | 1992 | Biochem. Pharmacol. | pmid:1610396 |
| Koshiishi I et al. | Quantification of lipid alkyl radicals trapped with nitroxyl radical via HPLC with postcolumn thermal decomposition. | 2005 | J. Lipid Res. | pmid:16106053 |
| Chichlowski MW et al. | Altering the fatty acids in milk fat by including canola seed in dairy cattle diets. | 2005 | J. Dairy Sci. | pmid:16107397 |
| Kim EJ et al. | Fatty acid profiles associated with microbial colonization of freshly ingested grass and rumen biohydrogenation. | 2005 | J. Dairy Sci. | pmid:16107412 |
| Simón E et al. | trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters. | 2006 | J. Nutr. Biochem. | pmid:16111872 |
| GarcÃa-de-Lorenzo A et al. | Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols. | 2005 | Br. J. Nutr. | pmid:16115356 |
| Oikawa D et al. | Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. | 2005 | Br. J. Nutr. | pmid:16115363 |
| Wang Y and Oram JF | Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. | 2005 | J. Biol. Chem. | pmid:16118212 |
| Thiébaut AC et al. | [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. | 2005 | Bull Cancer | pmid:16123005 |
| Astorg P | [Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]. | 2005 | Bull Cancer | pmid:16123006 |
| Bougnoux P and Menanteau J | [Dietary fatty acids and experimental carcinogenesis]. | 2005 | Bull Cancer | pmid:16123007 |
| Bardon S et al. | [Dietary fatty acids and cancer: potential cellular and molecular mechanisms]. | 2005 | Bull Cancer | pmid:16123008 |
| Canudas N et al. | Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone. | 2005 | Pharmazie | pmid:16124404 |
| Laowtammathron C et al. | Factors affecting cryosurvival of nuclear-transferred bovine and swamp buffalo blastocysts: effects of hatching stage, linoleic acid-albumin in IVC medium and Ficoll supplementation to vitrification solution. | 2005 | Theriogenology | pmid:16125561 |
| Ennouri M et al. | Evaluation of some biological parameters of Opuntia ficus indica. 1. Influence of a seed oil supplemented diet on rats. | 2006 | Bioresour. Technol. | pmid:16129601 |
| Wang YL et al. | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. | 2005 | Anal Bioanal Chem | pmid:16132135 |
| Cheng Z et al. | The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. | 2005 | Biochim. Biophys. Acta | pmid:16140575 |
| Jung KA et al. | Cardiovascular protective properties of kiwifruit extracts in vitro. | 2005 | Biol. Pharm. Bull. | pmid:16141561 |
| Murakami A et al. | New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages. | 2005 | Biochem. Pharmacol. | pmid:16143312 |
| Alba-Loureiro TC et al. | Role of insulin on PGE2 generation during LPS-induced lung inflammation in rats. | 2006 | Life Sci. | pmid:16143347 |
| Payne ET et al. | Nutritional therapy improves function and complements corticosteroid intervention in mdx mice. | 2006 | Muscle Nerve | pmid:16149047 |
| Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 2. Maternal diets and stage of incubation on the lipid metabolism of quail embryos. | 1992 | Poult. Sci. | pmid:1614943 |
| Vaughan JE and Walsh SW | Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. | 2005 | Am. J. Obstet. Gynecol. | pmid:16150282 |
| pmid:16153670 | ||||
| Kummerow FA et al. | 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. | 2006 | Life Sci. | pmid:16154158 |