| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Seizures | D012640 | 87 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Raes K et al. | The deposition of conjugated linoleic acids in eggs of laying hens fed diets varying in fat level and fatty acid profile. | 2002 | J. Nutr. | pmid:11823576 |
| Baron CP et al. | Concentration effects in myoglobin-catalyzed peroxidation of linoleate. | 2002 | J. Agric. Food Chem. | pmid:11829662 |
| Joo ST et al. | Effects of dietary conjugated linoleic acid on fatty acid composition, lipid oxidation, color, and water-holding capacity of pork loin. | 2002 | J. Anim. Sci. | pmid:11831506 |
| Minemoto Y et al. | Oxidation of linoleic acid encapsulated with gum arabic or maltodextrin by spray-drying. | 2002 Mar-Apr | J Microencapsul | pmid:11837973 |
| Lemaitre RN et al. | Cell membrane trans-fatty acids and the risk of primary cardiac arrest. | 2002 | Circulation | pmid:11839624 |
| Cahoon EB et al. | Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. | 2002 | Plant Physiol. | pmid:11842164 |
| Ramirez DC and Gimenez MS | Lipid modification in mouse peritoneal macrophages after chronic cadmium exposure. | 2002 | Toxicology | pmid:11844611 |
| Calder PC | Conjugated linoleic acid in humans--reasons to be cheerful? | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844976 |
| Napolitano A et al. | Reactions of hydro(pero)xy derivatives of polyunsaturated fatty acids/esters with nitrite ions under acidic conditions. Unusual nitrosative breakdown of methyl 13-hydro(pero)xyoctadeca-9,11-dienoate to a novel 4-nitro-2-oximinoalk-3-enal product. | 2002 | J. Org. Chem. | pmid:11846653 |
| Hernández A et al. | In vivo activation of plasma membrane H(+)-ATPase hydrolytic activity by complex lipid-bound unsaturated fatty acids in Ustilago maydis. | 2002 | Eur. J. Biochem. | pmid:11846803 |
| Papanikolaou S and Aggelis G | Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture. | 2002 | Bioresour. Technol. | pmid:11848376 |
| Sheu MY et al. | Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. | 2002 | J. Invest. Dermatol. | pmid:11851881 |
| Pappas A et al. | Metabolic fate and selective utilization of major fatty acids in human sebaceous gland. | 2002 | J. Invest. Dermatol. | pmid:11851890 |
| Reyes-De-Corcuera JI et al. | Improved amperometric method for the rapid and quantitative measurement of lipoxygenase activity in vegetable tissue crude homogenates. | 2002 | J. Agric. Food Chem. | pmid:11853470 |
| Whitlock LA et al. | Fish oil and extruded soybeans fed in combination increase conjugated linoleic acids in milk of dairy cows more than when fed separately. | 2002 | J. Dairy Sci. | pmid:11860116 |
| Lichtenstein AH et al. | Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects. | 2002 | J. Lipid Res. | pmid:11861668 |
| Ishido E et al. | Kinetic expression for the oxidation of linoleic and arachidonic acid esters in their mixed system. | 2002 | Biosci. Biotechnol. Biochem. | pmid:11866122 |
| Futakuchi M et al. | Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). | 2002 | Cancer Lett. | pmid:11867197 |
| Sakurai T et al. | Short-term efficacy of enteral nutrition in the treatment of active Crohn's disease: a randomized, controlled trial comparing nutrient formulas. | 2002 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:11871742 |
| van Dam RM et al. | Dietary fat and meat intake in relation to risk of type 2 diabetes in men. | 2002 | Diabetes Care | pmid:11874924 |
| Inouye K et al. | Deodorization of soybean proteins by enzymatic and physicochemical treatments. | 2002 | J. Agric. Food Chem. | pmid:11879052 |
| Jardine D et al. | Liquid chromatography-mass spectrometry (LC-MS) investigation of the thiobarbituric acid reactive substances (TBARS) reaction. | 2002 | J. Agric. Food Chem. | pmid:11879064 |
| Urquhart P et al. | The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:11880240 |
| Evans M et al. | Trans-10, cis-12 conjugated linoleic acid increases fatty acid oxidation in 3T3-L1 preadipocytes. | 2002 | J. Nutr. | pmid:11880570 |
| Svahn JC et al. | Different quantities and quality of fat in milk products given to young children: effects on long chain polyunsaturated fatty acids and trans fatty acids in plasma. | 2002 | Acta Paediatr. | pmid:11885548 |
| Dichtl W et al. | Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation. | 2002 | Metab. Clin. Exp. | pmid:11887169 |
| Bolte MR et al. | Feeding lambs high-oleate or high-linoleate safflower seeds differentially influences carcass fatty acid composition. | 2002 | J. Anim. Sci. | pmid:11890397 |
| Wiegand BR et al. | Duration of feeding conjugated linoleic acid influences growth performance, carcass traits, and meat quality of finishing barrows. | 2002 | J. Anim. Sci. | pmid:11890399 |
| Beaulieu AD et al. | Concentrations of conjugated linoleic acid (cis-9, trans-11-octadecadienoic acid) are not increased in tissue lipids of cattle fed a high-concentrate diet supplemented with soybean oil. | 2002 | J. Anim. Sci. | pmid:11890424 |
| Yang H et al. | Effect of conjugated linoleic acid on the formation of spontaneous and PhIP-induced mutation in the colon and cecum of rats. | 2002 | Mutat. Res. | pmid:11890945 |
| Kawai T et al. | Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma. | 2002 | Diabetes Res. Clin. Pract. | pmid:11891015 |
| Roberts DC | Nutrition and metabolism. | 2002 | Curr. Opin. Lipidol. | pmid:11891423 |
| Whigham LD et al. | Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893615 |
| Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |
| King LM et al. | Cloning of CYP2J2 gene and identification of functional polymorphisms. | 2002 | Mol. Pharmacol. | pmid:11901223 |
| Du M and Ahn DU | Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. | 2002 | Poult. Sci. | pmid:11902422 |
| Galindo-Cuspinera V et al. | Comparison of volatile compounds in water- and oil-soluble annatto (Bixa orellana L.) extracts. | 2002 | J. Agric. Food Chem. | pmid:11902949 |
| Kikuzaki H et al. | Antioxidant properties of ferulic acid and its related compounds. | 2002 | J. Agric. Food Chem. | pmid:11902973 |
| Nakaya A et al. | Helicobacter pylori alters n-6 fatty acid metabolism and prostaglandin E2 synthesis in rat gastric mucosal cells. | 2001 | J. Gastroenterol. Hepatol. | pmid:11903735 |
| Hurtado de Catalfo GE and de Gomez Dumm IN | Polyunsaturated fatty acid biosynthesis from [1-14C]20:3 n-6 acid in rat cultured Sertoli cells. Linoleic acid effect. | 2002 | Int. J. Biochem. Cell Biol. | pmid:11906823 |
| Rong R et al. | Dietary oxidized fatty acids may enhance intestinal apolipoprotein A-I production. | 2002 | J. Lipid Res. | pmid:11907138 |
| Hatano T et al. | Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects. | 2002 | Phytochemistry | pmid:11909632 |
| Rum P and Hornstra G | The n-3 and n-6 polyunsaturated fatty acid composition of plasma phospholipids in pregnant women and their infants. relationship with maternal linoleic acid intake. | 2002 | Clin. Chem. Lab. Med. | pmid:11916268 |
| Ramanadham S et al. | Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations. | 2002 | Biochim. Biophys. Acta | pmid:11923099 |
| Gravena C et al. | Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. | 2002 | J. Endocrinol. | pmid:11927386 |
| Boggia R et al. | Classification and class-modeling of "Riviera Ligure" extra-virgin olive oil using chemical-physical parameters. | 2002 | J. Agric. Food Chem. | pmid:11929311 |
| Abu-Ghazaleh AA et al. | Feeding fish meal and extruded soybeans enhances the conjugated linoleic acid (CLA) content of milk. | 2002 | J. Dairy Sci. | pmid:11949867 |
| Nosjean O and Boutin JA | Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part? | 2002 | Cell. Signal. | pmid:11955950 |
| Yamasaki M et al. | Effect of dietary conjugated linoleic acid on the in vivo growth of rat hepatoma dRLh-84. | 2001 | Nutr Cancer | pmid:11962249 |
| Tischendorf F et al. | Influence of a conjugated linoleic acid mixture on growth, organ weights, carcass traits and meat quality in growing pigs. | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:11972681 |
| Park CW et al. | Inclusion complex of conjugated linoleic acid (CLA) with cyclodextrins. | 2002 | J. Agric. Food Chem. | pmid:11982428 |
| Hung CY and Yen GC | Antioxidant activity of phenolic compounds isolated from Mesona procumbens Hemsl. | 2002 | J. Agric. Food Chem. | pmid:11982431 |
| Terpstra AH et al. | The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. | 2002 | J. Nutr. | pmid:11983818 |
| Stepień K et al. | Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins. | 2000 | Acta Biochim. Pol. | pmid:11996116 |
| Fremann D et al. | Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women. | 2002 | Public Health Nutr | pmid:12001981 |
| Corino C et al. | Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits. | 2002 | J. Anim. Sci. | pmid:12002308 |
| Madron MS et al. | Effect of extruded full-fat soybeans on conjugated linoleic acid content of intramuscular, intermuscular, and subcutaneous fat in beef steers. | 2002 | J. Anim. Sci. | pmid:12002322 |
| Szentmihályi K et al. | Rose hip (Rosa canina L.) oil obtained from waste hip seeds by different extraction methods. | 2002 | Bioresour. Technol. | pmid:12003323 |
| Parris N et al. | Effect of endogenous triacylglycerol hydrolysates on the mechanical properties of Zein films from ground corn. | 2002 | J. Agric. Food Chem. | pmid:12010002 |
| RodrÃguez E et al. | Trans-10, cis-12, but not cis-9, trans-11 CLA isomer, inhibits brown adipocyte thermogenic capacity. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12010762 |
| Gregório SM et al. | Effect of dietary linoleic acid on the progression of chronic renal failure in rats. | 2002 | Braz. J. Med. Biol. Res. | pmid:12011943 |
| Hennig B et al. | PCB-induced oxidative stress in endothelial cells: modulation by nutrients. | 2002 | Int J Hyg Environ Health | pmid:12018021 |
| Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
| Lecka-Czernik B et al. | Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. | 2002 | Endocrinology | pmid:12021203 |
| Bull AW et al. | Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. | 2002 | Biochim. Biophys. Acta | pmid:12031293 |
| Dobbins RL et al. | The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats. | 2002 | Diabetes | pmid:12031970 |
| Penumetcha M et al. | Enhanced solubilization and intestinal absorption of cholesterol by oxidized linoleic acid. | 2002 | J. Lipid Res. | pmid:12032164 |
| Dufour C et al. | Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation. | 2002 | J. Agric. Food Chem. | pmid:12033806 |
| Akahoshi A et al. | Conjugated linoleic acid reduces body fats and cytokine levels of mice. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036077 |
| Dunbar BL and Bauer JE | Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. | 2002 | J. Nutr. | pmid:12042499 |
| Banni S | Conjugated linoleic acid metabolism. | 2002 | Curr. Opin. Lipidol. | pmid:12045395 |
| Sijben JW et al. | Interactions of dietary polyunsaturated fatty acids and vitamin E with regard to vitamin E status, fat composition and antibody responsiveness in layer hens. | 2002 | Br. Poult. Sci. | pmid:12047096 |
| Mantzouridou F et al. | Optimization of beta-carotene production from synthetic medium by Blakeslea trispora: a mathematical modeling. | 2002 | Appl. Biochem. Biotechnol. | pmid:12049204 |
| Belury MA | Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. | 2002 | Annu. Rev. Nutr. | pmid:12055356 |
| Adlof RO et al. | Analysis of conjugated linoleic acid-enriched triacylglycerol mixtures by isocratic silver-ion high-performance liquid chromatography. | 2002 | J Chromatogr A | pmid:12058943 |
| Laaksonen DE et al. | Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. | 2002 | Diabet. Med. | pmid:12060056 |
| Culbertson SM et al. | Determination of the alpha-tocopherol inhibition rate constant for peroxidation in low-density lipoprotein. | 2002 | Chem. Res. Toxicol. | pmid:12067255 |
| Thuillier P et al. | Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. | 2002 | Biochem. J. | pmid:12069687 |
| Waylan AT et al. | Effects of modified tall oil and vitamin E on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. | 2002 | J. Anim. Sci. | pmid:12078739 |
| Averette Gatlin L et al. | The effects of dietary fat sources, levels, and feeding intervals on pork fatty acid composition. | 2002 | J. Anim. Sci. | pmid:12078742 |
| Iwamoto M et al. | Serum lipid profiles in Japanese women and men during consumption of walnuts. | 2002 | Eur J Clin Nutr | pmid:12080402 |
| Watanabe Y et al. | Suppressive effect of saturated acyl L-ascorbate on the oxidation of linoleic acid encapsulated with maltodextrin or gum arabic by spray-drying. | 2002 | J. Agric. Food Chem. | pmid:12083870 |
| Yu L et al. | Conjugated linoleic acid isomers differ in their free radical scavenging properties. | 2002 | J. Agric. Food Chem. | pmid:12083897 |
| Ward AT et al. | Bovine milk fatty acid profiles produced by feeding diets containing solin, flax and canola. | 2002 | J. Dairy Sci. | pmid:12086055 |
| Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |
| Stark KD et al. | Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. | 2002 Jul-Aug | Nutrition | pmid:12093443 |
| Wolfe RR et al. | Dietary fat composition alters pulmonary function in pigs. | 2002 Jul-Aug | Nutrition | pmid:12093447 |
| Ealey KN et al. | Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. | 2001 | Nutr Cancer | pmid:12094611 |
| Park HJ et al. | Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. | 2001 | Nutr Cancer | pmid:12094615 |
| Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
| Pillai MG et al. | Biosynthesis of triacylglycerol molecular species in an oleaginous fungus, Mortierella ramanniana var. angulispora. | 2002 | J. Biochem. | pmid:12097168 |
| Hontecillas R et al. | Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. | 2002 | J. Nutr. | pmid:12097686 |
| Kimura Y | Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. | 2002 | J. Nutr. | pmid:12097695 |
| Barros MF et al. | Cord blood essential fatty acid and alpha-tocopherol in full-term newborns in a Northeast Brazil area. | 2002 | Int J Vitam Nutr Res | pmid:12098883 |
| Chajès V et al. | Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. | 2002 | Cancer Epidemiol. Biomarkers Prev. | pmid:12101117 |
| Zhao X et al. | Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). | 2002 | J. Biol. Chem. | pmid:12101222 |
| Anwar F et al. | Analytical characterization of Salicornia bigelovii seed oil cultivated in Pakistan. | 2002 | J. Agric. Food Chem. | pmid:12105947 |
| Østdal H et al. | Reaction between protein radicals and other biomolecules. | 2002 | Free Radic. Biol. Med. | pmid:12106816 |
| Schlame M et al. | Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. | 2002 | Ann. Neurol. | pmid:12112112 |
| Shinohara R et al. | Evaluation of antilipid peroxidative action of propolis ethanol extract. | 2002 | Phytother Res | pmid:12112290 |