| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Lactose Intolerance | D007787 | 2 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Harris WS | Linoleic acid and coronary heart disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951772 |
| Webb AN et al. | Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. | 2008 Nov-Dec | Nutrition | pmid:18619813 |
| Magalhães MS et al. | Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats. | 2008 May-Jun | Acta Cir Bras | pmid:18552998 |
| Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
| Yu IS et al. | Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. | 2008 Jan-Feb | Biotechnol. Prog. | pmid:18197675 |
| Nushida H et al. | Adipocere formation via hydrogenation of linoleic acid in a victim kept under dry concealment. | 2008 | Forensic Sci. Int. | pmid:17644293 |
| Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
| Tattersall AL and Wilkins RJ | Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. | 2008 | Pflugers Arch. | pmid:18204856 |
| Onoue S et al. | In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study. | 2008 | Eur J Pharm Sci | pmid:18207709 |
| Gaillard D et al. | The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. | 2008 | FASEB J. | pmid:18162488 |
| Aronis A et al. | Lipotoxic effects of triacylglycerols in J774.2 macrophages. | 2008 | Nutrition | pmid:18165129 |
| Garelnabi M et al. | Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. | 2008 | Atherosclerosis | pmid:18243209 |
| Laus MN et al. | Plant inner membrane anion channel (PIMAC) function in plant mitochondria. | 2008 | Plant Cell Physiol. | pmid:18511459 |
| Hwang YC et al. | Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. | 2008 | Antiviral Res. | pmid:18243348 |
| Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
| Spacek T et al. | Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18248766 |
| Al-Turkmani MR et al. | A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA. | 2008 | J. Lipid Res. | pmid:18480495 |
| Feng DD et al. | Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. | 2008 | J. Endocrinol. | pmid:18252961 |
| Canudas N et al. | Photosensitizing properties of Actarit, an antirheumatic drug. | 2008 | Arzneimittelforschung | pmid:18540480 |
| Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
| Sikorski AM et al. | Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. | 2008 | Brain Res. | pmid:18456247 |
| Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
| Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
| Kuiper HC et al. | Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | 2008 | J. Biol. Chem. | pmid:18442969 |
| Ohmori H et al. | Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice. | 2008 | Pathobiology | pmid:18580068 |
| Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
| Garscha U and Oliw E | Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18586008 |
| Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
| Wejnerowska G et al. | Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. | 2008 | Anal Sci | pmid:18544865 |
| Morishita M et al. | Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. | 2008 | J Control Release | pmid:18804128 |
| Iqbal MJ et al. | A combination of CLA-DAG oil modifies the diabetic phenotype in male Zucker diabetic fatty rats. | 2008 | Horm. Metab. Res. | pmid:18548385 |
| Zhao YF et al. | Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. | 2008 | J. Endocrinol. | pmid:18550787 |
| Still K et al. | The peroxisome proliferator activator receptor alpha/delta agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo. | 2008 | Calcif. Tissue Int. | pmid:18836674 |
| Martinelli N et al. | FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | 2008 | Am. J. Clin. Nutr. | pmid:18842780 |
| Saez G et al. | Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks? | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18687407 |
| Suh HN et al. | Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18842827 |
| Rahuman AA et al. | Mosquito larvicidal activity of oleic and linoleic acids isolated from Citrullus colocynthis (Linn.) Schrad. | 2008 | Parasitol. Res. | pmid:18688644 |
| Wang J et al. | 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18843019 |
| Luna P et al. | Gas chromatography and silver-ion high-performance liquid chromatography analysis of conjugated linoleic acid isomers in free fatty acid form using sulphuric acid in methanol as catalyst. | 2008 | J Chromatogr A | pmid:18692191 |
| Damsgaard CT et al. | Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men. | 2008 | J. Nutr. | pmid:18492834 |
| Morita M and Tokita M | Hydroxy radical, hexanal, and decadienal generation by autocatalysts in autoxidation of linoleate alone and with eleostearate. | 2008 | Lipids | pmid:18493810 |
| Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
| Methy N et al. | Dietary fatty acids and recurrence of colorectal adenomas in a European intervention trial. | 2008 | Nutr Cancer | pmid:18791918 |
| Jacquot C et al. | Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18793849 |
| O'Connell ED et al. | Diet and risk factors for age-related maculopathy. | 2008 | Am. J. Clin. Nutr. | pmid:18326611 |
| Windstam S and Nelson EB | Temporal release of fatty acids and sugars in the spermosphere: impacts on Enterobacter cloacae-induced biological control. | 2008 | Appl. Environ. Microbiol. | pmid:18515478 |
| Boeglin WE et al. | Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases. | 2008 | Lipids | pmid:18795358 |
| Hernández ML et al. | The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. | 2008 | J. Exp. Bot. | pmid:18515829 |
| Whittle EJ et al. | Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18796606 |
| Mochizuki K et al. | PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. | 2008 | J. Nutr. Sci. Vitaminol. | pmid:18797151 |
| Ito-Inaba Y et al. | Characterization of the plant uncoupling protein, SrUCPA, expressed in spadix mitochondria of the thermogenic skunk cabbage. | 2008 | J. Exp. Bot. | pmid:18308738 |
| Jacquot C et al. | Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. | 2008 | Org. Biomol. Chem. | pmid:18972057 |
| Carrasco MP et al. | Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | 2008 | FEBS J. | pmid:18312412 |
| Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
| Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
| Ashby RD et al. | Property control of sophorolipids: influence of fatty acid substrate and blending. | 2008 | Biotechnol. Lett. | pmid:18264681 |
| Zhu H et al. | 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. | 2008 | Int. J. Cancer | pmid:18785202 |
| Ringseis R et al. | Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. | 2008 | Eur J Nutr | pmid:18264811 |
| Fang KM et al. | Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. | 2008 | Cardiovasc. Res. | pmid:18267958 |
| Kishino T et al. | Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. | 2008 | Clin. Chim. Acta | pmid:18771663 |
| Rashid S et al. | Topical omega-3 and omega-6 fatty acids for treatment of dry eye. | 2008 | Arch. Ophthalmol. | pmid:18268213 |
| Jones PJ et al. | The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. | 2008 | Metab. Clin. Exp. | pmid:18702944 |
| Hofmann E and Pollmann S | Molecular mechanism of enzymatic allene oxide cyclization in plants. | 2008 | Plant Physiol. Biochem. | pmid:18272375 |
| Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |
| Artmann A et al. | Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | 2008 | Biochim. Biophys. Acta | pmid:18316044 |
| McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
| Or-Rashid MM et al. | Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18797866 |
| El-Yassimi A et al. | Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. | 2008 | J. Biol. Chem. | pmid:18321850 |
| Ferrini G et al. | Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. | 2008 | Poult. Sci. | pmid:18281580 |
| Brosnan MJ and Carkner RD | Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. | 2008 | Am. J. Hypertens. | pmid:18437120 |
| Andersson C et al. | Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. | 2008 | J. Lipid Res. | pmid:18441018 |
| Petit HV et al. | Quality of embryos produced from dairy cows fed whole flaxseed and the success of embryo transfer. | 2008 | J. Dairy Sci. | pmid:18420609 |
| Fan X et al. | Factors affecting thermally induced furan formation. | 2008 | J. Agric. Food Chem. | pmid:18811167 |
| Caffieri S et al. | UVB photolysis of hydrocortisone 21-acetate. | 2008 | J Pharm Biomed Anal | pmid:18423938 |
| Godkin JD et al. | Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production. | 2008 | Reprod. Biol. Endocrinol. | pmid:18811942 |
| Swida A et al. | Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. | 2008 | Biochem. J. | pmid:18402555 |
| Ates B et al. | Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). | 2008 | Free Radic. Res. | pmid:18404536 |
| Davison GW et al. | In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis. | 2008 | Free Radic. Res. | pmid:18404537 |
| Brook MA et al. | Using a drug to structure its release matrix and release profile. | 2008 | Int J Pharm | pmid:18407444 |
| Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
| Satou T et al. | The toxin produced by pleurotus ostreatus reduces the head size of nematodes. | 2008 | Biol. Pharm. Bull. | pmid:18379043 |
| Chung SH et al. | Synthesis of conjugated linoleic acid by human-derived Bifidobacterium breve LMC 017: utilization as a functional starter culture for milk fermentation. | 2008 | J. Agric. Food Chem. | pmid:18410112 |
| Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
| Kuriki K et al. | Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice. | 2008 | Cancer Sci. | pmid:19038002 |
| Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
| Kanwar RK et al. | Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. | 2008 | Clin. Exp. Allergy | pmid:18005183 |
| Maqbool A et al. | Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18955866 |
| Zuo Y et al. | ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. | 2008 | J. Biol. Chem. | pmid:18957418 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activities of traditional Japanese cereal grains. | 2008 | J. UOEH | pmid:19086696 |
| Wang J et al. | Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. | 2008 | Nutr Cancer | pmid:18584483 |
| Zanoni S et al. | Growth kinetics on oligo- and polysaccharides and promising features of three antioxidative potential probiotic strains. | 2008 | J. Appl. Microbiol. | pmid:18778294 |
| Tao M et al. | Relationship of polyunsaturated fatty acid intake to peripheral neuropathy among adults with diabetes in the National Health and Nutrition Examination Survey (NHANES) 1999 2004. | 2008 | Diabetes Care | pmid:17914029 |
| Mateu-de Antonio J et al. | Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. | 2008 | Br. J. Nutr. | pmid:17916276 |
| Rahman MM et al. | Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. | 2008 | J. Cell. Physiol. | pmid:17929247 |
| Ku CS and Mun SP | Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste. | 2008 | Bioresour. Technol. | pmid:17931856 |
| Sarikurkcu C et al. | Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays. | 2008 | Bioresour. Technol. | pmid:17920880 |
| Moon CD et al. | Reclassification of Clostridium proteoclasticum as Butyrivibrio proteoclasticus comb. nov., a butyrate-producing ruminal bacterium. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768601 |
| Vinceti M et al. | Food intake and risk of cutaneous melanoma in an Italian population. | 2008 | Eur J Clin Nutr | pmid:17657227 |
| Damsgaard CT et al. | The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. | 2008 | Br. J. Nutr. | pmid:17663804 |
| Astorg P et al. | Plasma n-6 and n-3 polyunsaturated fatty acids as biomarkers of their dietary intakes: a cross-sectional study within a cohort of middle-aged French men and women. | 2008 | Eur J Clin Nutr | pmid:17622261 |