| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Heart Defects, Congenital | D006330 | 20 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pornputtapitak W et al. | Development of γ-Oryzanol Rich Extract from Leum Pua Glutinous Rice Bran Loaded Nanostructured Lipid Carriers for Topical Delivery. | 2018 | J Oleo Sci | pmid:29367479 |
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| Liu Q et al. | Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. | 2017 Mar-Apr | Asian J. Androl. | pmid:26763547 |
| Krizhanovskii C et al. | EndoC-βH1 cells display increased sensitivity to sodium palmitate when cultured in DMEM/F12 medium. | 2017 | Islets | pmid:28277987 |
| Monastero R et al. | Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids. | 2017 | Eur J Nutr | pmid:26707994 |
| Liu F et al. | Simultaneous silencing of GhFAD2-1 and GhFATB enhances the quality of cottonseed oil with high oleic acid. | 2017 | J. Plant Physiol. | pmid:28644971 |
| Bentrad N et al. | Identification and evaluation of antibacterial agents present in lipophilic fractions isolated from sub-products of Phoenix dactilyfera. | 2017 | Nat. Prod. Res. | pmid:28403631 |
| Fan Y et al. | Study of the pH-sensitive mechanism of tumor-targeting liposomes. | 2017 | Colloids Surf B Biointerfaces | pmid:27940165 |
| Woodfield HK et al. | Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds. | 2017 | Plant Physiol. | pmid:28188274 |
| Cardenia V et al. | Dietary effects of Raphanus sativus cv Sango on lipid and oxysterols accumulation in rat brain: A lipidomic study on a non-genetic obesity model. | 2017 | Chem. Phys. Lipids | pmid:28539223 |
| Zhou Y et al. | UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28424210 |
| Du H et al. | Extraction and the Fatty Acid Profile of Rosa acicularis Seed Oil. | 2017 | J Oleo Sci | pmid:29129896 |
| Teh SS et al. | Recovery and Utilization of Palm Oil Mill Effluent Source as Value-Added Food Products. | 2017 | J Oleo Sci | pmid:29093377 |
| Leitch AC et al. | B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. | 2017 | Toxicology | pmid:28552552 |
| De Weirdt R et al. | Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. | 2017 | Environ. Microbiol. | pmid:27883264 |
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| Wang XH et al. | High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2. | 2017 | Front Pharmacol | pmid:28555106 |
| Song S et al. | Identification of pork flavour precursors from enzyme-treated lard using Maillard model system assessed by GC-MS and partial least squares regression. | 2017 | Meat Sci. | pmid:27792915 |
| Zhao A et al. | Use of real-time cellular analysis and Plackett-Burman design to develop the serum-free media for PC-3 prostate cancer cells. | 2017 | PLoS ONE | pmid:28945791 |
| Qian J et al. | Agonist-induced activation of human FFA1 receptor signals to extracellular signal-regulated kinase 1 and 2 through Gq- and Gi-coupled signaling cascades. | 2017 | Cell. Mol. Biol. Lett. | pmid:28747926 |
| Kim H et al. | Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. | 2017 | Nutr J | pmid:28420388 |
| Cocchi M et al. | Linoleic acid: Is this the key that unlocks the quantum brain? Insights linking broken symmetries in molecular biology, mood disorders and personalistic emergentism. | 2017 | BMC Neurosci | pmid:28420346 |
| Sinanoglou VJ et al. | Factors affecting human colostrum fatty acid profile: A case study. | 2017 | PLoS ONE | pmid:28410426 |
| Buckley MT et al. | Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes. | 2017 | Mol. Biol. Evol. | pmid:28333262 |
| Inzaugarat ME et al. | New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans. | 2017 | PLoS ONE | pmid:28257515 |
| Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| Fujii M | Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice. | 2017 | Yakugaku Zasshi | pmid:28049895 |
| Turell L et al. | The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. | 2017 | J. Biol. Chem. | pmid:27923813 |
| Segal LN et al. | Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. | 2017 | Thorax | pmid:27486204 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Tiburcio TC et al. | Connexin32 deficiency is associated with liver injury, inflammation and oxidative stress in experimental non-alcoholic steatohepatitis. | 2017 | Clin. Exp. Pharmacol. Physiol. | pmid:27859493 |
| Rashed MM et al. | Effect of ultrasonic treatment on total phenolic extraction from Lavandula pubescens and its application in palm olein oil industry. | 2016 | Ultrason Sonochem | pmid:26584982 |
| Liu Y and Roth JP | A Revised Mechanism for Human Cyclooxygenase-2. | 2016 | J. Biol. Chem. | pmid:26565028 |
| Medema S et al. | Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. | 2016 | Schizophr Bull | pmid:26385764 |
| Rosenblat M et al. | Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes. | 2016 | Lipids | pmid:27344666 |
| Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
| Stewart CJ et al. | Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease. | 2016 | Microbiome | pmid:28034304 |
| Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
| Montaño A et al. | Fatty Acid and Phenolic Compound Concentrations in Eight Different Monovarietal Virgin Olive Oils from Extremadura and the Relationship with Oxidative Stability. | 2016 | Int J Mol Sci | pmid:27886101 |
| Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
| Wang S et al. | Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26879142 |
| McNamara RK and Welge JA | Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. | 2016 | Bipolar Disord | pmid:27087497 |
| Ramsden CE et al. | Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). | 2016 | BMJ | pmid:27071971 |
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| Garsetti M et al. | Fat composition of vegetable oil spreads and margarines in the USA in 2013: a national marketplace analysis. | 2016 | Int J Food Sci Nutr | pmid:27046021 |
| Wang JJ et al. | Two ω-3 FADs Are Associated with Peach Fruit Volatile Formation. | 2016 | Int J Mol Sci | pmid:27043529 |
| Ramsden CE et al. | Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? | 2016 | Mol Pain | pmid:27030719 |
| Domenichiello AF et al. | The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. | 2016 | J. Nutr. Biochem. | pmid:27012633 |
| Yary T et al. | Serum n-6 polyunsaturated fatty acids, Δ5- and Δ6-desaturase activities, and risk of incident type 2 diabetes in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. | 2016 | Am. J. Clin. Nutr. | pmid:27009754 |