| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Heart Defects, Congenital | D006330 | 20 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Netsu S et al. | Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. | 2008 | Fertil. Steril. | pmid:18054352 |
| Diniz YS et al. | Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. | 2008 | Eur. J. Pharmacol. | pmid:18054909 |
| Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
| Ogata K et al. | Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | 2008 | J. Pharm. Pharmacol. | pmid:18088500 |
| Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
| Kim T et al. | Pharmacokinetics of formulated tenoxicam transdermal delivery systems. | 2008 | J. Pharm. Pharmacol. | pmid:18088513 |
| Gaillard D et al. | The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. | 2008 | FASEB J. | pmid:18162488 |
| Berquin IM et al. | Multi-targeted therapy of cancer by omega-3 fatty acids. | 2008 | Cancer Lett. | pmid:18479809 |
| Al-Turkmani MR et al. | A mechanism accounting for the low cellular level of linoleic acid in cystic fibrosis and its reversal by DHA. | 2008 | J. Lipid Res. | pmid:18480495 |
| Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
| Kuiper HC et al. | Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | 2008 | J. Biol. Chem. | pmid:18442969 |
| Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
| Wejnerowska G et al. | Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. | 2008 | Anal Sci | pmid:18544865 |
| Zhao YF et al. | Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. | 2008 | J. Endocrinol. | pmid:18550787 |
| Martinelli N et al. | FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | 2008 | Am. J. Clin. Nutr. | pmid:18842780 |
| Saez G et al. | Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks? | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18687407 |
| Suh HN et al. | Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18842827 |
| Wang J et al. | 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18843019 |
| Damsgaard CT et al. | Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men. | 2008 | J. Nutr. | pmid:18492834 |
| Ogorodnikova AV et al. | Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. | 2008 | Phytochemistry | pmid:18952245 |
| Windstam S and Nelson EB | Temporal release of fatty acids and sugars in the spermosphere: impacts on Enterobacter cloacae-induced biological control. | 2008 | Appl. Environ. Microbiol. | pmid:18515478 |
| Hernández ML et al. | The utilization and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. | 2008 | J. Exp. Bot. | pmid:18515829 |
| Tao X et al. | GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. | 2008 | Anal Bioanal Chem | pmid:18622754 |
| Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
| Granvogl M et al. | Development of a stable isotope dilution assay for the quantitation of glycidamide and its application to foods and model systems. | 2008 | J. Agric. Food Chem. | pmid:18624425 |
| Jacquot C et al. | Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. | 2008 | Org. Biomol. Chem. | pmid:18972057 |
| Alghazeer R et al. | Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). | 2008 | Toxicol. Lett. | pmid:18625293 |
| Fagali N and Catalá A | Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. | 2008 | Biophys. Chem. | pmid:18656302 |
| Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
| Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
| McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
| de Virville JD et al. | Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. | 2008 | Planta | pmid:18663470 |
| Andersson C et al. | Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. | 2008 | J. Lipid Res. | pmid:18441018 |
| Godkin JD et al. | Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production. | 2008 | Reprod. Biol. Endocrinol. | pmid:18811942 |
| Yara A et al. | Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18373976 |
| Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
| Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
| Swida A et al. | Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. | 2008 | Biochem. J. | pmid:18402555 |
| Ates B et al. | Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC). | 2008 | Free Radic. Res. | pmid:18404536 |
| Satou T et al. | The toxin produced by pleurotus ostreatus reduces the head size of nematodes. | 2008 | Biol. Pharm. Bull. | pmid:18379043 |
| Gallardo E et al. | Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. | 2008 | J. Agric. Food Chem. | pmid:18386901 |
| Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
| Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
| Tian Z et al. | Preparation and evaluation of a linoleic-acid-modified amphiphilic polypeptide copolymer as a carrier for controlled drug release. | 2008 | Biomed Mater | pmid:19029601 |
| Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
| Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
| Kuriki K et al. | Relationships between intestinal polyp formation and fatty acid levels in plasma, erythrocytes, and intestinal polyps in Min mice. | 2008 | Cancer Sci. | pmid:19038002 |
| Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
| Maqbool A et al. | Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18955866 |
| Zuo Y et al. | ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. | 2008 | J. Biol. Chem. | pmid:18957418 |
| Ueda Y et al. | Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. | 2008 | Nutr Res | pmid:19083414 |
| Lopes PA et al. | Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. | 2008 | Nutr Res | pmid:19083449 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activities of traditional Japanese cereal grains. | 2008 | J. UOEH | pmid:19086696 |
| Safaa HM et al. | Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. | 2008 | Poult. Sci. | pmid:18648054 |
| Crean C et al. | Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals. | 2008 | Chem. Res. Toxicol. | pmid:18159932 |
| Bueno AA et al. | Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. | 2008 | Pflugers Arch. | pmid:17717684 |
| Tepe B | Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq), Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey. | 2008 | Bioresour. Technol. | pmid:17531471 |
| Xanthopoulou MN et al. | Biological studies of new organotin(IV) complexes of thioamide ligands. | 2008 | Eur J Med Chem | pmid:17509733 |
| Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
| Chechetkin IR et al. | Regio- and stereospecificity of recombinant soybean lipoxygenase-2. | 2007 Jul-Aug | Dokl. Biochem. Biophys. | pmid:17933341 |
| Ardestani A and Yazdanparast R | Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. | 2007 | Food Chem. Toxicol. | pmid:17673348 |
| Labadaridis I et al. | Linoleic and arachidonic acid in perinatal asphyxia and prematurity. | 2007 | J. Matern. Fetal. Neonatal. Med. | pmid:17674280 |
| Kummerow FA et al. | Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991616 |
| Roman-Nunez M et al. | Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. | 2007 | J. Food Sci. | pmid:17995782 |
| Yano M et al. | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. | 2007 | Antimicrob. Agents Chemother. | pmid:17420205 |
| Yuan S and Chang SK | Selected odor compounds in soymilk as affected by chemical composition and lipoxygenases in five soybean materials. | 2007 | J. Agric. Food Chem. | pmid:17227075 |
| Ye P et al. | The alteration of plasminogen activator inhibitor-1 expression by linoleic acid and fenofibrate in HepG2 cells. | 2007 | Blood Coagul. Fibrinolysis | pmid:17179821 |
| Javadi M et al. | The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. | 2007 | J Anim Physiol Anim Nutr (Berl) | pmid:17217386 |
| Gülçin I et al. | Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. | 2007 | Phytother Res | pmid:17221941 |
| Agostoni C et al. | Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:17204967 |
| Rosa A et al. | Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. | 2007 | Chem. Biol. Interact. | pmid:17194458 |
| Goupy P et al. | Dietary antioxidants as inhibitors of the heme-induced peroxidation of linoleic acid: mechanism of action and synergism. | 2007 | Free Radic. Biol. Med. | pmid:17697938 |
| Breza JM et al. | Monosodium glutamate but not linoleic acid differentially activates gustatory neurons in the rat geniculate ganglion. | 2007 | Chem. Senses | pmid:17693416 |
| Walkowiak J et al. | Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. | 2007 | J. Pediatr. Gastroenterol. Nutr. | pmid:18030219 |
| AbouZid S and Orihara Y | Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. | 2007 | Planta Med. | pmid:17973205 |
| Lin D et al. | Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. | 2007 | J. Org. Chem. | pmid:17979284 |
| Shin SC et al. | Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. | 2007 | Pharm Dev Technol | pmid:17963142 |
| Takajo T et al. | Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid. | 2007 | J. Lipid Res. | pmid:17337722 |
| Ou L et al. | Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17400188 |
| Liou YA et al. | Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. | 2007 | J. Nutr. | pmid:17374659 |
| Kolar SS et al. | Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. | 2007 | Cancer Res. | pmid:17545640 |
| Guo W et al. | Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17519282 |
| Yoneda T et al. | The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests. | 2007 | Physiol. Behav. | pmid:17459430 |
| Laidler P et al. | Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? | 2007 | Arch. Biochem. Biophys. | pmid:17466258 |
| Cao ZP et al. | Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP. | 2007 | Neurosci. Lett. | pmid:17466453 |
| Yin D et al. | Construction of a high-efficient expression vector of Delta12 fatty acid desaturase in peanut and its prokaryotical expression. | 2007 | J Genet Genomics | pmid:17469780 |
| Sauer LA et al. | Dietary factors and growth and metabolism in experimental tumors. | 2007 | J. Nutr. Biochem. | pmid:17418560 |
| Bongers ME et al. | The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. | 2007 | Nutr J | pmid:17428343 |
| Pittman D et al. | Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats. | 2007 | Brain Res. | pmid:17428454 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |
| Subauste AR and Burant CF | Role of FoxO1 in FFA-induced oxidative stress in adipocytes. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17374693 |
| Gaquerel E et al. | Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. | 2007 | Biochim. Biophys. Acta | pmid:17428728 |
| Tanaka T et al. | Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. | 2007 | FEBS J. | pmid:17451430 |
| Van Nieuwenhove CP et al. | Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. | 2007 | Lett. Appl. Microbiol. | pmid:17451511 |
| Kim JH et al. | Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. | 2007 | Poult. Sci. | pmid:17495090 |
| Pinna A et al. | Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. | 2007 | Cornea | pmid:17413949 |
| Lindenmeier M et al. | A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system. | 2007 | Mol Nutr Food Res | pmid:17680718 |
| Gorjão R et al. | Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. | 2007 | J. Lipid Res. | pmid:17592174 |
| Cadirci E et al. | Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. | 2007 | Chem. Biol. Interact. | pmid:17681286 |
| Risé P et al. | Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. | 2007 | Eur. J. Pharmacol. | pmid:17655842 |