| MeSH term | MeSH ID | Detail |
|---|---|---|
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Heart Defects, Congenital | D006330 | 20 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
| Garcia HS et al. | Interesterification (acidolysis) of butterfat with conjugated linoleic acid in a batch reactor. | 2000 | J. Dairy Sci. | pmid:10750090 |
| Rubbo H et al. | Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate. | 2000 | J. Biol. Chem. | pmid:10753874 |
| Trimborn M et al. | Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity. | 2000 Mar-Jun | Ophthalmic Res. | pmid:10754440 |
| Hubbard NE et al. | Reduction of murine mammary tumor metastasis by conjugated linoleic acid. | 2000 | Cancer Lett. | pmid:10755392 |
| Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
| Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
| Littman ED et al. | Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. | 2000 | Pancreas | pmid:10766451 |
| Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
| Kritharides L | Ascorbic acid and copper in linoleate oxidation--Dunkley revisited. | 1999 | Redox Rep. | pmid:10772064 |
| Siefken W et al. | Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes. | 2000 | Exp. Dermatol. | pmid:10772388 |
| Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
| Liégeois C et al. | Measuring antioxidant efficiency of wort, malt, and hops against the 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. | 2000 | J. Agric. Food Chem. | pmid:10775361 |
| Talcott ST et al. | Antioxidant changes and sensory properties of carrot puree processed with and without periderm tissue. | 2000 | J. Agric. Food Chem. | pmid:10775391 |
| Hover CG and Kulkarni AP | A simple and efficient method for hemoglobin removal from mammalian tissue cytosol by zinc sulfate and its application to the study of lipoxygenase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780874 |
| Charnock JS | Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780878 |
| McCarty MF | Toward a wholly nutritional therapy for type 2 diabetes. | 2000 | Med. Hypotheses | pmid:10783493 |
| McEvoy TG et al. | Fatty acid composition of lipids in immature cattle, pig and sheep oocytes with intact zona pellucida. | 2000 | J. Reprod. Fertil. | pmid:10793638 |
| Mandin O et al. | Volatile compounds from potato-like model systems. | 1999 | J. Agric. Food Chem. | pmid:10794636 |
| Kaya A | Properties and stability of butter oil obtained from milk and yoghurt. | 2000 | Nahrung | pmid:10795582 |
| Itokazu N et al. | Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. | 2000 | Brain Res. | pmid:10799687 |
| Gupta SV and Khosla P | Pork fat and chicken fat similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2000 | J. Nutr. | pmid:10801922 |
| Iwase H et al. | Effect of cytochrome c on the linoleic acid-degrading activity of porcine leukocyte 12-lipoxygenase. | 2000 | Free Radic. Biol. Med. | pmid:10802222 |
| Kachhap SK et al. | Effect of omega-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line. | 2000 | Cancer Lett. | pmid:10806298 |
| Lapillonne A et al. | Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10817283 |
| Decsi T et al. | Effect of type of early infant feeding on fatty acid composition of plasma lipid classes in full-term infants during the second 6 months of life. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10817286 |
| Pham TQ et al. | Antioxidant properties of crocin from Gardenia jasminoides Ellis and study of the reactions of crocin with linoleic acid and crocin with oxygen. | 2000 | J. Agric. Food Chem. | pmid:10820042 |
| Dhiman TR et al. | Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. | 2000 | J. Dairy Sci. | pmid:10821577 |
| Tominaga K et al. | Effect of linoleic acid-albumin on post-thaw survival of in vitro-produced bovine embryos at the 16-cell stage. | 2000 | J. Vet. Med. Sci. | pmid:10823739 |
| Peebles ED et al. | Effects of dietary fat type and level on broiler breeder performance. | 2000 | Poult. Sci. | pmid:10824949 |
| Azain MJ et al. | Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. | 2000 | J. Nutr. | pmid:10827208 |
| Tokumura A et al. | Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase. | 2000 | J. Lipid Res. | pmid:10828088 |
| Bloodsworth A et al. | Manganese-porphyrin reactions with lipids and lipoproteins. | 2000 | Free Radic. Biol. Med. | pmid:10832063 |
| Maccarrone M et al. | Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833416 |
| McHowat J and Creer MH | Selective plasmalogen substrate utilization by thrombin-stimulated Ca(2+)-independent PLA(2) in cardiomyocytes. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10843891 |
| Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
| Smith JC et al. | Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat. | 2000 Apr 1-15 | Physiol. Behav. | pmid:10854925 |
| Williams JP et al. | The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves. | 2000 | Biochem. J. | pmid:10861220 |
| Yoshiki Y et al. | Chemiluminescence and reactive oxygen scavenging activities of the hydrogen peroxide/gallic acid/lactoperoxidase system. | 2000 May-Jun | Luminescence | pmid:10862147 |
| Watanabe T et al. | Formation of acyl radical in lipid peroxidation of linoleic acid by manganese-dependent peroxidase from Ceriporiopsis subvermispora and Bjerkandera adusta. | 2000 | Eur. J. Biochem. | pmid:10866827 |
| Decsi T and Koletzko B | Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. | 2000 | Nutrition | pmid:10869902 |
| Latour MA et al. | Effects of conjugated linoleic acid. 1. Fatty acid modification of yolks and neonatal fatty acid metabolism. | 2000 | Poult. Sci. | pmid:10875761 |
| Latour MA et al. | Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids. | 2000 | Poult. Sci. | pmid:10875762 |
| Kumar KV et al. | Oxidant stress and essential fatty acids in patients with risk and established ARDS. | 2000 | Clin. Chim. Acta | pmid:10876008 |
| Loreau O et al. | Large-scale preparation of (9Z,12E)-[1-(13)C]-octadeca-9,12-dienoic acid, (9Z,12Z,15E)-[1-(13)C]-octadeca-9,12,15-trienoic acid and their [1-(13)C] all-cis isomers. | 2000 | Chem. Phys. Lipids | pmid:10878236 |
| Lesage F et al. | Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. | 2000 | J. Biol. Chem. | pmid:10880510 |
| Gonzalez B et al. | Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883061 |
| Tominaga K et al. | Effect of lipid polarization by centrifugation at different developmental stages on post-thaw survival of bovine in vitro produced 16-cell embryos. | 2000 | Theriogenology | pmid:10883852 |
| Moussa M et al. | Relationship between the fatty acid composition of rat lymphocytes and immune functions. | 2000 | Br. J. Nutr. | pmid:10884721 |
| Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |