| MeSH term | MeSH ID | Detail |
|---|---|---|
| Spirochaetales Infections | D013145 | 2 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kageyama K et al. | Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. | 1989 | J Appl Toxicol | pmid:2926093 |
| Booker ML et al. | Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. | 1989 | Gastroenterology | pmid:2507386 |
| Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
| Glatz JF et al. | Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. | 1989 | Am. J. Clin. Nutr. | pmid:2916448 |
| Bernbäck S et al. | Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. | 1989 | Biochim. Biophys. Acta | pmid:2917153 |
| Hubbard NE and Erickson KL | Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. | 1989 | Cancer Lett. | pmid:2920371 |
| Tchervenkov JI et al. | The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. | 1989 | Transplantation | pmid:2643225 |
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| Fairbank J et al. | Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study. | 1989 | Clin. Chim. Acta | pmid:2612010 |
| Park JH et al. | Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. | 1989 | Digestion | pmid:2612750 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Kurganov BI et al. | Kinetics of soybean lipoxygenase reaction in hydrated reversed micelles. | 1989 | Biochimie | pmid:2474334 |
| Gardner HW | Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. | 1989 | Biochim. Biophys. Acta | pmid:2492826 |
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| Hansen O | Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2554979 |
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| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Blanken R et al. | Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions. | 1989 | Contact Derm. | pmid:2706971 |
| Levay-Young BK and Nandi S | Spermidine is necessary for, but not the only mediator of, linoleic acid-stimulated alpha-casein accumulation in mouse mammary epithelial cells. | 1989 | Endocrinology | pmid:2759031 |
| Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
| Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
| Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
| Klein A et al. | The effect of fatty acids on the vulnerability of lymphocytes to cortisol. | 1989 | Metab. Clin. Exp. | pmid:2537454 |
| Christon R et al. | Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. | 1989 | Biochim. Biophys. Acta | pmid:2538158 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Diehl AK et al. | Dietary intake and the prevalence of gallbladder disease in Mexican Americans. | 1989 | Gastroenterology | pmid:2583417 |
| Szamel M et al. | Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. | 1989 | J. Immunol. | pmid:2530278 |
| Schneider YJ | Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. | 1989 | J. Immunol. Methods | pmid:2644356 |
| Watkins BA | Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. | 1989 | Br. J. Nutr. | pmid:2923859 |
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| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
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| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Appel MJ et al. | Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. | 1990 | Cancer Lett. | pmid:2257542 |
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| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
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| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
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