Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Hennig B et al. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. 1996 Am. J. Clin. Nutr. pmid:8602587
Anderson RL Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. 1982 Am. J. Clin. Nutr. pmid:7081132
Jeppesen PB et al. Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. 1999 Am. J. Clin. Nutr. pmid:10393142
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Thijssen MA and Mensink RP Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. 2005 Am. J. Clin. Nutr. pmid:16155261
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Abbey M et al. Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. 1993 Am. J. Clin. Nutr. pmid:8438773
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Vaughan JE and Walsh SW Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. 2005 Am. J. Obstet. Gynecol. pmid:16150282
Liu H et al. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. 2015 Am. J. Pathol. pmid:25447051
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Pandey NR et al. An induction in hepatic HDL secretion associated with reduced ATPase expression. 2009 Am. J. Pathol. pmid:19717637
Thomson AB et al. A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. 1987 Am. J. Physiol. pmid:3826353
Düsing R et al. Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. 1983 Am. J. Physiol. pmid:6337507
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
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Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
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Emmison N et al. Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. 1995 Am. J. Physiol. pmid:7631907
Thomas ME et al. Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. 1995 Am. J. Physiol. pmid:7611458
Chen ZY et al. Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. 1997 Am. J. Physiol. pmid:9038989
WILSON JD Relation between dietary cholesterol and bile acid excretion in the rat. 1962 Am. J. Physiol. pmid:14001040
Nilsson A et al. Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. 1987 Am. J. Physiol. pmid:3109253
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Jayawickreme SP et al. Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. 1999 Am. J. Physiol. pmid:10198357
DeLany JP et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. 1999 Am. J. Physiol. pmid:10198400
Bogdanov KY et al. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. 1998 Am. J. Physiol. pmid:9486261
Chen ZY et al. Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. 1995 Am. J. Physiol. pmid:7864247
Hjelte L et al. Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. 1990 Am. J. Physiol. pmid:2115302
Phifer CB and Berthoud HR Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. 1998 Am. J. Physiol. pmid:9841547
Meyer C et al. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. 1997 Am. J. Physiol. pmid:9316458
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