Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Kiliç T et al. Fatty acid composition of seeds of some species of Nepeta L. 2007 Nat. Prod. Res. pmid:17487620
Ardestani A and Yazdanparast R Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. 2007 Food Chem. Toxicol. pmid:17673348
Labadaridis I et al. Linoleic and arachidonic acid in perinatal asphyxia and prematurity. 2007 J. Matern. Fetal. Neonatal. Med. pmid:17674280
Pérez-Matute P et al. Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin. 2007 Lipids pmid:17647039
Segovia-Siapco G et al. Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. 2007 Public Health Nutr pmid:17261227
Shen SR et al. Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. 2007 Mol Nutr Food Res pmid:17262883
Zhu X and Sayre LM Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. 2007 Redox Rep. pmid:17263908
Kummerow FA et al. Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. 2007 Prostaglandins Other Lipid Mediat. pmid:17991616
Roman-Nunez M et al. Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. 2007 J. Food Sci. pmid:17995782
Yano M et al. Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. 2007 Antimicrob. Agents Chemother. pmid:17420205
Ringseis R et al. Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver. 2007 J. Nutr. pmid:17182804
Ben-Shabat S et al. Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. 2007 Drug Dev Ind Pharm pmid:18058312
Yuan S and Chang SK Selected odor compounds in soymilk as affected by chemical composition and lipoxygenases in five soybean materials. 2007 J. Agric. Food Chem. pmid:17227075
Griel AE et al. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. 2007 Nutr J pmid:17227589
Ye P et al. The alteration of plasminogen activator inhibitor-1 expression by linoleic acid and fenofibrate in HepG2 cells. 2007 Blood Coagul. Fibrinolysis pmid:17179821
Javadi M et al. The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. 2007 J Anim Physiol Anim Nutr (Berl) pmid:17217386
Clément M et al. Whey-derived free fatty acids suppress the germination of Candida albicans in vitro. 2007 FEMS Yeast Res. pmid:17034417
Gülçin I et al. Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. 2007 Phytother Res pmid:17221941
Somparn P et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. 2007 Biol. Pharm. Bull. pmid:17202663
Agostoni C et al. Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:17204967
Todorov VT et al. Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression. 2007 Hypertension pmid:17785633
Rosa A et al. Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. 2007 Chem. Biol. Interact. pmid:17194458
Güllçin I and Daştan A Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. 2007 J Enzyme Inhib Med Chem pmid:18237020
Lin YH and Salem N Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. 2007 J. Lipid Res. pmid:17876057
Willett WC The role of dietary n-6 fatty acids in the prevention of cardiovascular disease. 2007 J Cardiovasc Med (Hagerstown) pmid:17876199
LaRosa PC et al. Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. 2007 Physiol. Genomics pmid:17878318
Duan X et al. Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention. 2007 Molecules pmid:17851428
You Y et al. Identification of major phenolic compounds of Chinese water chestnut and their antioxidant activity. 2007 Molecules pmid:17851436
Gillilan RE et al. Structural basis for activation of fatty acid-binding protein 4. 2007 J. Mol. Biol. pmid:17761196
Goupy P et al. Dietary antioxidants as inhibitors of the heme-induced peroxidation of linoleic acid: mechanism of action and synergism. 2007 Free Radic. Biol. Med. pmid:17697938
Sum CS et al. Identification of residues important for agonist recognition and activation in GPR40. 2007 J. Biol. Chem. pmid:17699519
Rittmann BE and Schloendorn J Engineering away lysosomal junk: medical bioremediation. 2007 Rejuvenation Res pmid:17708688
Yuri M et al. Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. 2007 Histopathology pmid:17711445
Breiden B et al. Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides. 2007 Eur. J. Cell Biol. pmid:17714827
Shyamala BN et al. Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. 2007 J. Agric. Food Chem. pmid:17715988
Aburai N et al. Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. 2007 Biosci. Biotechnol. Biochem. pmid:17690455
Sato I et al. Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. 2007 J. Vet. Med. Sci. pmid:17675801
Muzio G et al. PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1. 2007 Int. J. Cancer pmid:17691108
Barrett E et al. Rapid screening method for analyzing the conjugated linoleic acid production capabilities of bacterial cultures. 2007 Appl. Environ. Microbiol. pmid:17277221
Breza JM et al. Monosodium glutamate but not linoleic acid differentially activates gustatory neurons in the rat geniculate ganglion. 2007 Chem. Senses pmid:17693416
Sclafani A et al. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17804586
Jouany JP et al. Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro. 2007 Lipids pmid:17406930
Walkowiak J et al. Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:18030219
Nam IS and Garnsworthy PC Factors influencing biohydrogenation and conjugated linoleic acid production by mixed rumen fungi. 2007 J. Microbiol. pmid:17618224
Nam IS and Garnsworthy PC Biohydrogenation of linoleic acid by rumen fungi compared with rumen bacteria. 2007 J. Appl. Microbiol. pmid:17714387
Or-Rashid MM et al. Fatty acid composition of ruminal bacteria and protozoa, with emphasis on conjugated linoleic acid, vaccenic acid, and odd-chain and branched-chain fatty acids. 2007 J. Anim. Sci. pmid:17145972
Bu DP et al. Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows. 2007 J. Dairy Sci. pmid:17235178
Thomas EA and Yao JK Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D. 2007 Schizophr. Res. pmid:17011169
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Tarnopolsky M et al. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. 2007 PLoS ONE pmid:17912368
Grechkin AN et al. Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots. 2007 Chembiochem pmid:17957816
Wallace RJ et al. Isomers of conjugated linoleic acids are synthesized via different mechanisms in ruminal digesta and bacteria. 2007 J. Lipid Res. pmid:17644775
AbouZid S and Orihara Y Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. 2007 Planta Med. pmid:17973205
Lin D et al. Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. 2007 J. Org. Chem. pmid:17979284
Al-Khalifa A et al. Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17122327
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Balesteros MR et al. Determination of olive oil acidity by CE. 2007 Electrophoresis pmid:17941122
Uehara Y et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. 2007 Atherosclerosis pmid:16730733
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Shin SC et al. Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. 2007 Pharm Dev Technol pmid:17963142
Schweiger D et al. Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. 2007 J. Lipid Res. pmid:17164225
Okuyama H et al. Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. 2007 World Rev Nutr Diet pmid:17167282
Degner SC et al. Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. 2007 Nutr Cancer pmid:18001219
Okuyama H et al. Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? 2007 World Rev Nutr Diet pmid:17167283
Okuyama H et al. Mechanisms by which dietary fats affect coronary heart disease mortality. 2007 World Rev Nutr Diet pmid:17167284
Okuyama H et al. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. 2007 World Rev Nutr Diet pmid:17167285
Mizushina Y et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. 2007 Biochimie pmid:17383068
Romero MM et al. The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats. 2007 Naunyn Schmiedebergs Arch. Pharmacol. pmid:17387456
Forsythe CE et al. Cholesterolaemic influence of palmitic acid in the sn-1, 3 v. the sn-2 position with high or low dietary linoleic acid in healthy young men. 2007 Br. J. Nutr. pmid:17391563
Lake SL et al. Effects of postpartum dietary fat and body condition score at parturition on plasma, adipose tissue, and milk fatty acid composition of lactating beef cows. 2007 J. Anim. Sci. pmid:17060413
Carpentier AC et al. Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17062840
Chalé-Rush A et al. Multiple routes of chemosensitivity to free fatty acids in humans. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17234892
Almendingen K et al. Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. 2007 Int. J. Cancer pmid:17096349
Maduko CO et al. Enzymatic interesterification of tripalmitin with vegetable oil blends for formulation of caprine milk infant formula analogs. 2007 J. Dairy Sci. pmid:17235135
Lauretani F et al. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. 2007 Eur. J. Neurol. pmid:17594339
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Sun CH et al. [Effects of conjugated linoleic acid on expression of GLUT4 protein in skeletal muscle of insulin resistant rat]. 2007 Zhonghua Yu Fang Yi Xue Za Zhi pmid:17484206
Yoneda T et al. The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests. 2007 Physiol. Behav. pmid:17459430
Laidler P et al. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? 2007 Arch. Biochem. Biophys. pmid:17466258
Cao ZP et al. Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP. 2007 Neurosci. Lett. pmid:17466453
Yin D et al. Construction of a high-efficient expression vector of Delta12 fatty acid desaturase in peanut and its prokaryotical expression. 2007 J Genet Genomics pmid:17469780
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Pittman D et al. Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats. 2007 Brain Res. pmid:17428454
Dufour C and Loonis M Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. 2007 Biochim. Biophys. Acta pmid:17428609
Subauste AR and Burant CF Role of FoxO1 in FFA-induced oxidative stress in adipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17374693
Gaquerel E et al. Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. 2007 Biochim. Biophys. Acta pmid:17428728
Li Z et al. Lipase-catalyzed esterification of conjugated linoleic acid with L-carnitine in solvent-free system and acetonitrile. 2007 Bioprocess Biosyst Eng pmid:17503088
Sankaran D et al. COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. 2007 J. Nutr. Biochem. pmid:17475460
Khatib S et al. An exogenous marker: a novel approach for the characterization of oxidative stress. 2007 Bioorg. Med. Chem. pmid:17407818
Pinna A et al. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. 2007 Cornea pmid:17413949
Bozzo F et al. Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. 2007 Chem. Biol. Interact. pmid:17632092
Lindenmeier M et al. A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system. 2007 Mol Nutr Food Res pmid:17680718
Gorjão R et al. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. 2007 J. Lipid Res. pmid:17592174
Cadirci E et al. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. 2007 Chem. Biol. Interact. pmid:17681286
Risé P et al. Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. 2007 Eur. J. Pharmacol. pmid:17655842
Rosberg-Cody E et al. Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. 2007 Microbiology (Reading, Engl.) pmid:17660413
Dufour C et al. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. 2007 Free Radic. Biol. Med. pmid:17603933
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003
Zeng YX et al. Comparative analysis of volatile components from Clematis species growing in China. 2007 Anal. Chim. Acta pmid:17606017
Hodge AM et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. 2007 Am. J. Clin. Nutr. pmid:17616780