Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Ennouri M et al. Evaluation of some biological parameters of Opuntia ficus indica. 1. Influence of a seed oil supplemented diet on rats. 2006 Bioresour. Technol. pmid:16129601
Rogerson ML et al. Kinetic studies of the interaction of fatty acids with phosphatidylcholine vesicles (liposomes). 2006 Colloids Surf B Biointerfaces pmid:16466910
Simón E et al. trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters. 2006 J. Nutr. Biochem. pmid:16111872
Yeh CS et al. Fatty acid metabolism pathway play an important role in carcinogenesis of human colorectal cancers by Microarray-Bioinformatics analysis. 2006 Cancer Lett. pmid:15885896
Reis A et al. Identification of linoleic acid free radicals and other breakdown products using spin trapping with liquid chromatography-electrospray tandem mass spectrometry. 2006 Biomed. Chromatogr. pmid:15981198
Fernanda Cury-Boaventura M et al. Mechanisms involved in Jurkat cell death induced by oleic and linoleic acids. 2006 Clin Nutr pmid:16859815
Kubo K et al. Induction of multidrug resistance-associated protein MRP3 in the liver of rats fed with docosahexaenoic acid. 2006 Biosci. Biotechnol. Biochem. pmid:16861802
Murrieta CM et al. Evaluation of milk somatic cells as a source of mRNA for study of lipogenesis in the mammary gland of lactating beef cows supplemented with dietary high-linoleate safflower seeds. 2006 J. Anim. Sci. pmid:16908643
Barlic J et al. Oxidized lipid-driven chemokine receptor switch, CCR2 to CX3CR1, mediates adhesion of human macrophages to coronary artery smooth muscle cells through a peroxisome proliferator-activated receptor gamma-dependent pathway. 2006 Circulation pmid:16908772
Jirovetz L et al. Chemical composition and antioxidant properties of clove leaf essential oil. 2006 J. Agric. Food Chem. pmid:16910723
Devillard E et al. Increased expression of a molecular chaperone GroEL in response to unsaturated fatty acids by the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens. 2006 FEMS Microbiol. Lett. pmid:16923082
Khanna S et al. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. 2006 J. Neurochem. pmid:16923160
Raju M et al. Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the beta-carotene uptake and its cleavage into retinol in rats. 2006 Mol. Cell. Biochem. pmid:16845492
Belosludtsev K et al. On the mechanism of palmitic acid-induced apoptosis: the role of a pore induced by palmitic acid and Ca2+ in mitochondria. 2006 J. Bioenerg. Biomembr. pmid:16847595
Fukuda S et al. Augmentation of vaccenate production and suppression of vaccenate biohydrogenation in cultures of mixed ruminal microbes. 2006 J. Dairy Sci. pmid:16507700
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Papetti A et al. Isolation of an in vitro and ex vivo antiradical melanoidin from roasted barley. 2006 J. Agric. Food Chem. pmid:16478238
Park YS et al. Prolyl endopeptidase inhibitory activity of unsaturated fatty acids. 2006 J. Agric. Food Chem. pmid:16478242
Amakura Y et al. Characteristic long-chain fatty acid of Pleurocybella porrigens. 2006 Shokuhin Eiseigaku Zasshi pmid:16984039
Kitaguchi H et al. Electron-transfer oxidation properties of unsaturated fatty acids and mechanistic insight into lipoxygenases. 2006 J Phys Chem A pmid:16451000
Torres AG et al. Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women. 2006 Br. J. Nutr. pmid:16512938
Hurley MS et al. Effects of fatty acids on skeletal muscle cell differentiation in vitro. 2006 Br. J. Nutr. pmid:16512949
Turchini GM et al. Fatty acid metabolism in the freshwater fish Murray cod (Maccullochella peelii peelii) deduced by the whole-body fatty acid balance method. 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16513379
Moon HS et al. Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. 2006 Arch. Biochem. Biophys. pmid:17084379
Wang XL et al. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. 2006 Diabetes pmid:16873694
Ollero M et al. Evidence of increased flux to n-6 docosapentaenoic acid in phospholipids of pancreas from cftr-/- knockout mice. 2006 Metab. Clin. Exp. pmid:16919538
DeMar JC et al. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. 2006 Biochim. Biophys. Acta pmid:16920015
Hall JA et al. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. 2006 J. Nutr. pmid:16920851
Fürstenberger G et al. What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? 2006 Int. J. Cancer pmid:16921484
Huang Y et al. Detection of free radical transfer in lipoxygenase I-B-catalyzed linoleic acid-soybean protein interaction by electron spin resonance spectroscopy (ESR). 2006 J. Agric. Food Chem. pmid:17117812
Bauer JE Metabolic basis for the essential nature of fatty acids and the unique dietary fatty acid requirements of cats. 2006 J. Am. Vet. Med. Assoc. pmid:17144816
Kisztelinski D et al. Application of a continuous bioreactor cascade to study the effect of linoleic acid on hybridoma cell physiology. 2006 Biotechnol. Bioeng. pmid:16894630
Warensjö E et al. Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men. 2006 Am. J. Clin. Nutr. pmid:16895896
Poole E and McQueen CE Conjugated linoleic acid. 2006 Am J Health Syst Pharm pmid:17057041
Chaillou LL and Nazareno MA New method to determine antioxidant activity of polyphenols. 2006 J. Agric. Food Chem. pmid:17061812
de Veth MJ et al. Response to conjugated linoleic acid in dairy cows differing in energy and protein status. 2006 J. Dairy Sci. pmid:17106094
Tian Q et al. Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. 2006 Chem. Biol. Interact. pmid:16540100
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Gülçin I Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). 2006 Toxicology pmid:16243424
Bryant D et al. Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans. 2006 Phytochemistry pmid:16797619
Song Q et al. Enzymatic synthesis of L-ascorbyl linoleate in organic media. 2006 Bioprocess Biosyst Eng pmid:16284781
Iqbal S et al. Antioxidant properties of methanolic extracts from leaves of Rhazya stricta. 2006 J Med Food pmid:16822215
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Payet MD et al. An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16822961
Kainou K et al. Isolation of Delta12 and omega3-fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and alpha-linolenic acids in Saccharomyces cerevisiae. 2006 Yeast pmid:16823888
Sammon AM and Iputo JE Maize meal predisposes to endemic squamous cancer of the oesophagus in Africa: breakdown of esterified linoleic acid to the free form in stored meal leads to increased intragastric PGE2 production and a low-acid reflux. 2006 Med. Hypotheses pmid:16824700
Goyens PL et al. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. 2006 Am. J. Clin. Nutr. pmid:16825680
Flood V et al. Lutein and zeaxanthin dietary intake and age related macular degeneration. 2006 Br J Ophthalmol pmid:16782963
Kumazawa K et al. Characterization of epoxydecenal isomers as potent odorants in black tea (Dimbula) infusion. 2006 J. Agric. Food Chem. pmid:16787030
Ando H et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. 2006 Biochem. J. pmid:16232122
Rodríguez-Lee M et al. Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16239593
Gülçin I Antioxidant and antiradical activities of L-carnitine. 2006 Life Sci. pmid:16253281
Feng DD et al. Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids. 2006 Endocrinology pmid:16254037
Szuchman A et al. Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages. 2006 Free Radic. Res. pmid:16298758
Friesen R and Innis SM Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16282365
Alba-Loureiro TC et al. Role of insulin on PGE2 generation during LPS-induced lung inflammation in rats. 2006 Life Sci. pmid:16143347
Payne ET et al. Nutritional therapy improves function and complements corticosteroid intervention in mdx mice. 2006 Muscle Nerve pmid:16149047
Miolo G et al. Photochemistry and phototoxicity of fluocinolone 16,17-acetonide. 2005 Mar-Apr Photochem. Photobiol. pmid:15535735
Colombo C et al. Plant-based diet, serum fatty acid profile, and free radicals in postmenopausal women: the diet and androgens (DIANA) randomized trial. 2005 Jul-Sep Int. J. Biol. Markers pmid:16240844
Nohl H et al. Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone. 2005 Jul-Aug Anticancer Res. pmid:16080529
Madigan C et al. Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes. 2005 Jan-Mar Ir J Med Sci pmid:15868884
Lalush I et al. Utilization of amylose-lipid complexes as molecular nanocapsules for conjugated linoleic Acid. 2005 Jan-Feb Biomacromolecules pmid:15638512
Ermidou-Pollet S et al. Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. 2005 Acta. Biol. Hung. pmid:16196200
Jung KA et al. Cardiovascular protective properties of kiwifruit extracts in vitro. 2005 Biol. Pharm. Bull. pmid:16141561
Thiébaut AC et al. [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. 2005 Bull Cancer pmid:16123005
Astorg P [Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]. 2005 Bull Cancer pmid:16123006
Bougnoux P and Menanteau J [Dietary fatty acids and experimental carcinogenesis]. 2005 Bull Cancer pmid:16123007
Bardon S et al. [Dietary fatty acids and cancer: potential cellular and molecular mechanisms]. 2005 Bull Cancer pmid:16123008
Lee JH et al. Enhancing alpha-tocopherol and linoleic acid in ewe's milk by feeding emulsified sunflower oil and DL-alpha-tocopheryl acetate in a chemically treated protein matrix. 2005 J. Agric. Food Chem. pmid:16076135
Moffitt JH et al. Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro. 2005 Diabetologia pmid:16094531
Hou CT et al. Evaluation of microbial strains for linoleic acid hydroxylation and reclassification of strain ALA2. 2005 Antonie Van Leeuwenhoek pmid:16096693
Trommer H et al. Further investigations on the role of ascorbic acid in stratum corneum lipid models after UV exposure. 2005 J. Pharm. Pharmacol. pmid:16102251
Koshiishi I et al. Quantification of lipid alkyl radicals trapped with nitroxyl radical via HPLC with postcolumn thermal decomposition. 2005 J. Lipid Res. pmid:16106053
Chichlowski MW et al. Altering the fatty acids in milk fat by including canola seed in dairy cattle diets. 2005 J. Dairy Sci. pmid:16107397
de Roos B et al. Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach. 2005 FASEB J. pmid:16055499
Mensink RP Metabolic and health effects of isomeric fatty acids. 2005 Curr. Opin. Lipidol. pmid:15650560
Loor JJ et al. Relationship among trans and conjugated fatty acids and bovine milk fat yield due to dietary concentrate and linseed oil. 2005 J. Dairy Sci. pmid:15653539
Schmidely P et al. Influence of extruded soybeans with or without bicarbonate on milk performance and fatty acid composition of goat milk. 2005 J. Dairy Sci. pmid:15653542
Lapidot T et al. Lipid hydroperoxidase activity of myoglobin and phenolic antioxidants in simulated gastric fluid. 2005 J. Agric. Food Chem. pmid:15853377
Pérez-Gilabert M et al. Purification and partial characterization of lipoxygenase from desert truffle (Terfezia claveryi Chatin) ascocarps. 2005 J. Agric. Food Chem. pmid:15853417
Armoni M et al. Free fatty acids repress the GLUT4 gene expression in cardiac muscle via novel response elements. 2005 J. Biol. Chem. pmid:16096283
Nielsen AA et al. Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. 2005 Aliment. Pharmacol. Ther. pmid:16305726
Hassimotto NM et al. Antioxidant activity of dietary fruits, vegetables, and commercial frozen fruit pulps. 2005 J. Agric. Food Chem. pmid:15826041
Nugent AP et al. The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. 2005 Eur J Clin Nutr pmid:15827560
Salem ML Systemic treatment with n-6 polyunsaturated fatty acids attenuates EL4 thymoma growth and metastasis through enhancing specific and non-specific anti-tumor cytolytic activities and production of TH1 cytokines. 2005 Int. Immunopharmacol. pmid:15829411
Kim HJ et al. A model for research on the blood-brain barrier disruption induced by unsaturated fatty acid emulsion. 2005 Invest Radiol pmid:15829824
Ribeiro CV et al. Biohydrogenation of fatty acids and digestibility of fresh alfalfa or alfalfa hay plus sucrose in continuous culture. 2005 J. Dairy Sci. pmid:16230707
Yuan YV et al. Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro. 2005 Food Chem. Toxicol. pmid:15833383
Sakai H and Kajiwara S Cloning and functional characterization of a Delta12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. 2005 Mol. Genet. Genomics pmid:15838640
Lengqvist J et al. Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha. 2005 J Mass Spectrom pmid:16258897
Burth P et al. Role of nonesterified unsaturated fatty acids in the pathophysiological processes of leptospiral infection. 2005 J. Infect. Dis. pmid:15593003
Hussein N et al. Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men. 2005 J. Lipid Res. pmid:15576848
Nagai T et al. Antioxidative ability in a linoleic acid oxidation system and scavenging abilities against active oxygen species of enzymatic hydrolysates from pollen Cistus ladaniferus. 2005 Int. J. Mol. Med. pmid:15647841
Lucchi L et al. Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients. 2005 Artif Organs pmid:15854218
Thijssen MA and Mensink RP Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. 2005 Am. J. Clin. Nutr. pmid:16155261
Wang Y and Oram JF Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. 2005 J. Biol. Chem. pmid:16118212
Herrera JA et al. Calcium plus linoleic acid therapy for pregnancy-induced hypertension. 2005 Int J Gynaecol Obstet pmid:16243339
Blask DE et al. Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. 2005 Endocrine pmid:16217131
Krist S et al. Analysis of volatile compounds and triglycerides of seed oils extracted from different poppy varieties (Papaver somniferum L.). 2005 J. Agric. Food Chem. pmid:16218681
Merchant AT et al. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. 2005 Am. J. Clin. Nutr. pmid:16155282