Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Metabolic Syndrome D024821 44 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Weight Loss D015431 56 associated lipids
Anorexia D000855 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Hyperpigmentation D017495 11 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Otte KB et al. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. 2013 ChemSusChem pmid:23934656
Tarawneh AH et al. Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans. 2013 J. Agric. Food Chem. pmid:24147790
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Khalil WA et al. Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. 2013 Theriogenology pmid:23683689
Le Maux S et al. β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. 2013 J. Dairy Sci. pmid:23684041
Zeng G et al. Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration. 2013 J Phys Chem A pmid:23347186
Calder PC Old study sheds new light on the fatty acids and cardiovascular health debate. 2013 BMJ pmid:23386269
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
Bassett JK et al. Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. 2013 Int. J. Cancer pmid:23575905
Hein LK et al. Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. 2013 J. Lipid Res. pmid:23564732
Zhao Y et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. 2013 PLoS ONE pmid:23565210
Han L et al. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. 2013 Food Chem. Toxicol. pmid:23959106
Herrera-Meza MS et al. Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. 2013 Int J Food Sci Nutr pmid:23360131
Chen CS et al. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24154509
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Alinezhad H et al. Biochemical activities of acetone extracts of Hyssopus angustifolius. 2012 Jul-Aug Acta Pol Pharm pmid:22876603
Moghaddam AH et al. Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. 2012 Jul-Aug Acta Pol Pharm pmid:22876611
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Chivandi E et al. Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. 2012 Jan-Feb In Vivo pmid:22210722
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Montaño M et al. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. 2012 Toxicol. Sci. pmid:22859314
Ebba S et al. The examination of fatty acid taste with edible strips. 2012 Physiol. Behav. pmid:22521910
Ruparel S et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. 2012 Pain pmid:22633978
Dramane G et al. STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. 2012 J. Clin. Invest. pmid:22546859
Naqvi AZ et al. Dietary fatty acids and peripheral artery disease in adults. 2012 Atherosclerosis pmid:22552117
Joshi S et al. Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. 2012 Org. Biomol. Chem. pmid:22986997
Perdriau S et al. Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. 2012 ChemSusChem pmid:23060315
Krugner-Higby L et al. Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. 2012 Comp. Med. pmid:23043777
Coimbra MC and Jorge N Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). 2012 J. Sci. Food Agric. pmid:21922463
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Marincola FC et al. A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. 2012 J. Matern. Fetal. Neonatal. Med. pmid:23025771
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Poompachee K and Chudapongse N Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. 2012 Med Princ Pract pmid:22024634
Sandoval-Montemayor NE et al. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. 2012 Molecules pmid:22992784
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Florence AC et al. Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. 2012 Food Chem pmid:22980792
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Taârit MB et al. Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. 2012 J. Sci. Food Agric. pmid:22173568
Byun HJ et al. Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. 2012 J. Dermatol. Sci. pmid:22209282
Beevi SS et al. Polyphenolics profile and antioxidant properties of Raphanus sativus L. 2012 Nat. Prod. Res. pmid:21714734
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Marei WF et al. Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. 2012 Reprod. Fertil. Dev. pmid:22697118
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Wu J et al. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. 2012 Acta Biochim. Biophys. Sin. (Shanghai) pmid:22687573
Xie J et al. Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. 2012 Nat. Prod. Res. pmid:21707231