| MeSH term | MeSH ID | Detail |
|---|---|---|
| Helicobacter Infections | D016481 | 21 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Hyperpigmentation | D017495 | 11 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Circoviridae Infections | D018173 | 2 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. | 2013 | Br. J. Nutr. | pmid:22883314 |
| Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
| Shen W et al. | Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. | 2013 | J. Lipid Res. | pmid:23401602 |
| Godinot N et al. | Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. | 2013 | Neuroscience | pmid:23831422 |
| Bartók T et al. | ESI-MS and MS/MS identification of the first ceramide analogues of fumonisin B₠mycotoxin from a Fusarium verticillioides culture following RP-HPLC separation. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23837460 |
| Okada Y et al. | Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23872318 |
| Song Y et al. | Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. | 2013 | Lipids Health Dis | pmid:23879935 |
| Wei J et al. | Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity. | 2013 | Circ. J. | pmid:23883876 |
| Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
| Falavigna C et al. | Fatty acid esters of fumonisins: first evidence of their presence in maize. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23819788 |
| Renner L et al. | Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. | 2013 | Nutrients | pmid:23857174 |
| Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
| SaÃn J et al. | Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. | 2013 | Ann. Nutr. Metab. | pmid:23594856 |
| Nørskov NP et al. | Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. | 2013 | J. Proteome Res. | pmid:23596967 |
| Hand KV et al. | Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. | 2013 | Eur J Nutr | pmid:22926626 |
| Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
| Carro M et al. | Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. | 2013 | Theriogenology | pmid:23273433 |
| Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
| Li A et al. | Thermally induced isomerization of linoleic acid in soybean oil. | 2013 | Chem. Phys. Lipids | pmid:23261796 |
| Mena J et al. | Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. | 2013 | Vet. Immunol. Immunopathol. | pmid:23267746 |
| Li L et al. | A novel galanin receptor 1a gene in zebrafish: tissue distribution, developmental expression roles in nutrition regulation. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23268327 |
| Raatz SK et al. | Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. | 2013 | J Acad Nutr Diet | pmid:23351633 |
| Soto-Guzman A et al. | Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23332799 |
| Poudyal H et al. | Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23333092 |
| Khan AA et al. | Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. | 2013 | Nanomedicine (Lond) | pmid:23311988 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Ramsden CE et al. | Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. | 2013 | BMJ | pmid:23386268 |
| Benjamin S et al. | Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. | 2013 | J Zhejiang Univ Sci B | pmid:23365010 |
| Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
| Chiou TY et al. | Characteristics and antioxidative ability of defatted rice bran extracts obtained using several extractants under subcritical conditions. | 2013 | J Oleo Sci | pmid:23357811 |
| Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
| Gousiadou C et al. | Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. | 2013 | J Enzyme Inhib Med Chem | pmid:22630074 |
| Ali Q et al. | Ameliorating effects of exogenously applied proline on seed composition, seed oil quality and oil antioxidant activity of maize (Zea mays L.) under drought stress. | 2013 | Int J Mol Sci | pmid:23344043 |
| Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
| Guo J et al. | Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. | 2013 | Animal | pmid:23031491 |
| Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
| Loizzo MR et al. | Phenolics, aroma profile, and in vitro antioxidant activity of Italian dessert passito wine from Saracena (Italy). | 2013 | J. Food Sci. | pmid:23574495 |
| Brouwer IA et al. | Trans fatty acids and cardiovascular health: research completed? | 2013 | Eur J Clin Nutr | pmid:23531781 |
| Mujtaba SF et al. | Singlet oxygen mediated apoptosis by anthrone involving lysosomes and mitochondria at ambient UV exposure. | 2013 | J. Hazard. Mater. | pmid:23542321 |
| Wardhani DH et al. | Inhibition kinetics of lipid oxidation of model foods by using antioxidant extract of fermented soybeans. | 2013 | Food Chem | pmid:23561179 |
| Bakır T et al. | Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II). | 2013 | J. Sci. Food Agric. | pmid:23520052 |
| Godovikova TS et al. | Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent. | 2013 | Bioconjug. Chem. | pmid:23521072 |
| Fujii M et al. | Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. | 2013 | Exp. Dermatol. | pmid:23528213 |
| Franco-Pons N et al. | Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. | 2013 | Ann. Surg. | pmid:22964727 |
| Ndhlala AR et al. | Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. | 2013 | Molecules | pmid:23377133 |
| Luo C et al. | Vegetable oil thermosets reinforced by tannin-lipid formulations. | 2013 | Acta Biomater | pmid:22975626 |
| Ramirez AM et al. | A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. | 2013 | Lipids | pmid:23893337 |
| Abdoul-Azize S et al. | Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus. | 2013 | PLoS ONE | pmid:23936306 |
| Kummerow FA et al. | Effects of trans fats on prostacyclin production. | 2013 | Scand. Cardiovasc. J. | pmid:24228623 |
| Vasudevan C et al. | The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. | 2013 | Nutr Clin Pract | pmid:24177284 |
| Stelzleni AM et al. | Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles. | 2013 | J. Anim. Sci. | pmid:23893987 |
| Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
| Kenny JG et al. | Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. | 2013 | PLoS ONE | pmid:23861785 |
| Xie J et al. | A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. | 2013 | Biomed Res Int | pmid:23862153 |
| Xia Q et al. | Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. | 2013 | Food Chem. Toxicol. | pmid:23867545 |
| Le Maux S et al. | Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. | 2013 | Food Chem | pmid:23870962 |
| Aladedunye F and Przybylski R | Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. | 2013 | Food Chem | pmid:23870970 |
| Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
| Green DP et al. | Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. | 2013 | Pain | pmid:23891895 |
| Ruparel S et al. | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. | 2013 | Pain | pmid:23867730 |
| Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
| de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
| Ngakegni-Limbili AC et al. | Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. | 2013 | J. Sci. Food Agric. | pmid:22692978 |
| Yamagishi K et al. | Plasma fatty acid composition and incident ischemic stroke in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | 2013 | Cerebrovasc. Dis. | pmid:23920478 |
| Ramsden CE et al. | Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959954 |
| Alinezhad H et al. | Biochemical activities of acetone extracts of Hyssopus angustifolius. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876603 |
| Moghaddam AH et al. | Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876611 |
| Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Chivandi E et al. | Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. | 2012 Jan-Feb | In Vivo | pmid:22210722 |
| Johnson GH and Fritsche K | Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials. | 2012 | J Acad Nutr Diet | pmid:22889633 |
| Matsubara T et al. | TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. | 2012 | J. Lipid Res. | pmid:23034213 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| Honkanen AM et al. | Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. | 2012 | J. Dairy Sci. | pmid:22365221 |
| Jadoon A et al. | Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. | 2012 | J Affect Disord | pmid:22113178 |
| Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
| Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Rohr-Udilova N et al. | Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. | 2012 | Hepatology | pmid:22105228 |
| Banti CN et al. | Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. | 2012 | Metallomics | pmid:22552402 |
| Dubé E et al. | Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. | 2012 | Biol. Reprod. | pmid:22553224 |
| Li J et al. | A chitosan induced 9-lipoxygenase in Adelostemma gracillimum seedlings. | 2012 | Int J Mol Sci | pmid:22312270 |
| Ruparel S et al. | The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. | 2012 | Mol Pain | pmid:23006841 |
| Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. | 2012 | Obesity (Silver Spring) | pmid:22334255 |
| Lee S et al. | Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. | 2012 | Br. J. Nutr. | pmid:21846428 |
| Sun X et al. | Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake. | 2012 | Int. J. Cancer | pmid:22322480 |
| Matesanz N et al. | Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms. | 2012 | J. Nutr. Biochem. | pmid:21840193 |
| Kim YS et al. | In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. | 2012 | Food Chem. Toxicol. | pmid:22921350 |
| Le Maux S et al. | β-Lactoglobulin as a molecular carrier of linoleate: characterization and effects on intestinal epithelial cells in vitro. | 2012 | J. Agric. Food Chem. | pmid:22924475 |
| Manzoor M et al. | Variation in minerals, phenolics and antioxidant activity of peel and pulp of different varieties of peach (Prunus persica L.) fruit from Pakistan. | 2012 | Molecules | pmid:22728349 |
| Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
| Steffen BT et al. | Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. | 2012 | Int J Obes (Lond) | pmid:21829163 |
| Roongpisuthipong W et al. | Essential fatty acid deficiency while a patient receiving fat regimen total parenteral nutrition. | 2012 | BMJ Case Rep | pmid:22707694 |
| Burrows T et al. | A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids. | 2012 | Eur J Clin Nutr | pmid:22378224 |
| Khan R et al. | Variation in oil content and fatty acid composition of the seed oil of Acacia species collected from the northwest zone of India. | 2012 | J. Sci. Food Agric. | pmid:22351513 |
| Chen MH and Nelson EB | Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. | 2012 | Phytopathology | pmid:22352306 |
| Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
| He M et al. | Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. | 2012 | J. Dairy Sci. | pmid:22365227 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Sultana B et al. | Investigation on the antioxidant activity of leaves, peels, stems bark, and kernel of mango (Mangifera indica L.). | 2012 | J. Food Sci. | pmid:22860576 |