| MeSH term | MeSH ID | Detail |
|---|---|---|
| Aortic Diseases | D001018 | 11 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Anorexia | D000855 | 8 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
| Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
| Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
| Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
| Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
| Cheng Z et al. | The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. | 2005 | Biochim. Biophys. Acta | pmid:16140575 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Claeys M et al. | Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. | 1985 | Biochim. Biophys. Acta | pmid:2996610 |
| DeWille JW and Farmer SJ | Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. | 1993 | Biochim. Biophys. Acta | pmid:8105893 |
| Park HG et al. | Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. | 2016 | Biochim. Biophys. Acta | pmid:26597785 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Haycock JC and Evers AS | Altered phosphoinositide fatty acid composition, mass and metabolism in brain essential fatty acid deficiency. | 1988 | Biochim. Biophys. Acta | pmid:2833931 |
| Villasuso AL et al. | Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. | 2005 | Biochim. Biophys. Acta | pmid:16024291 |
| Dutta-Roy AK et al. | Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. | 1993 | Biochim. Biophys. Acta | pmid:8334153 |
| Yamamoto T et al. | Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3015226 |
| Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
| Walstra P et al. | Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:3115302 |
| Colard O et al. | Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. | 1987 | Biochim. Biophys. Acta | pmid:3115303 |
| SHAW R | THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. | 1965 | Biochim. Biophys. Acta | pmid:14320219 |
| Greenspan MD et al. | Studies on the in vivo synthesis of triacylglycerol in mouse liver. | 1982 | Biochim. Biophys. Acta | pmid:7055591 |
| WILLS ED | MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS. | 1965 | Biochim. Biophys. Acta | pmid:14325327 |
| Okano G and Shimojo T | Utilization of long-chain free fatty acids in white and red muscle of rats. | 1982 | Biochim. Biophys. Acta | pmid:7066350 |
| Zhou L et al. | Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. | 1997 | Biochim. Biophys. Acta | pmid:9434134 |
| Cheah AM | Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. | 1981 | Biochim. Biophys. Acta | pmid:6118177 |
| Bauldry SA et al. | Activation of cytosolic phospholipase A2 in permeabilized human neutrophils. | 1996 | Biochim. Biophys. Acta | pmid:8555268 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
| Kanazawa K and Ashida H | Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. | 1998 | Biochim. Biophys. Acta | pmid:9748647 |
| Kanazawa K and Ashida H | Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. | 1998 | Biochim. Biophys. Acta | pmid:9748650 |
| Brasitus TA and Dudeja PK | Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. | 1988 | Biochim. Biophys. Acta | pmid:3128322 |
| Nilsson A and Landin B | Metabolism of chylomicron arachidonic and linoleic acid in the rat. | 1988 | Biochim. Biophys. Acta | pmid:3128335 |
| Jernerén F et al. | Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. | 2010 | Biochim. Biophys. Acta | pmid:20045744 |
| Daoud G et al. | Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. | 2005 | Biochim. Biophys. Acta | pmid:15708366 |
| Deva R et al. | Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. | 2000 | Biochim. Biophys. Acta | pmid:10903481 |
| Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
| Figueroa V et al. | Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. | 2013 | Biochim. Biophys. Acta | pmid:23261389 |
| Venkatraman JT and Clandinin MT | Ribonucleic acid efflux from isolated mouse liver nuclei is altered by diet and genotypically determined change in nuclear envelope composition. | 1988 | Biochim. Biophys. Acta | pmid:2452656 |
| Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
| Gardner HW | Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. | 1989 | Biochim. Biophys. Acta | pmid:2492826 |
| Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
| Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
| Imaizumi K et al. | Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. | 1989 | Biochim. Biophys. Acta | pmid:2508745 |
| Minich DM et al. | Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. | 1999 | Biochim. Biophys. Acta | pmid:10216285 |
| Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
| Luthria DL and Sprecher H | A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. | 1994 | Biochim. Biophys. Acta | pmid:8011670 |
| Woldseth B and Christophersen BO | Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. | 1994 | Biochim. Biophys. Acta | pmid:8011678 |
| Yu Y et al. | Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. | 2002 | Biochim. Biophys. Acta | pmid:12020636 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Garg ML et al. | Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. | 1992 | Biochim. Biophys. Acta | pmid:1606171 |
| Ek BA et al. | Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. | 1997 | Biochim. Biophys. Acta | pmid:9187305 |
| Hansen O | Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2554979 |
| Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
| Mahmmoud YA and Christensen SB | Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. | 2011 | Biochim. Biophys. Acta | pmid:21767529 |
| Ghafoorunissa A et al. | Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. | 2005 | Biochim. Biophys. Acta | pmid:15801047 |
| Hulea SA et al. | Bilirubin sensitized photooxidation of human plasma low density lipoprotein. | 1996 | Biochim. Biophys. Acta | pmid:8982266 |
| Bull AW et al. | Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. | 2002 | Biochim. Biophys. Acta | pmid:12031293 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
| Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Kitagawa S et al. | Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. | 1984 | Biochim. Biophys. Acta | pmid:6435686 |
| Ivanetich KM et al. | Delta 6-desaturase: improved methodology and analysis of the kinetics in a multi-enzyme system. | 1996 | Biochim. Biophys. Acta | pmid:8547334 |
| Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
| Sprinz H et al. | Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. | 2000 | Biochim. Biophys. Acta | pmid:10601698 |
| Byczkowski JZ and Kulkarni AP | Vanadium redox cycling, lipid peroxidation and co-oxygenation of benzo(a)pyrene-7,8-dihydrodiol. | 1992 | Biochim. Biophys. Acta | pmid:1315157 |
| Parsons HG et al. | Modulation of human erythrocyte shape and fatty acids by diet. | 1986 | Biochim. Biophys. Acta | pmid:3741859 |
| Hirabara SM et al. | Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. | 2006 | Biochim. Biophys. Acta | pmid:16375848 |
| DeMar JC et al. | Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. | 2006 | Biochim. Biophys. Acta | pmid:16920015 |
| Bedotti R et al. | Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. | 1990 | Biochim. Biophys. Acta | pmid:2163687 |
| Brinkmeier H et al. | Specific modifications of the membrane fatty acid composition of human myotubes and their effects on the muscular sodium channels. | 1993 | Biochim. Biophys. Acta | pmid:8380720 |
| Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
| Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
| Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
| Raederstorff D and Moser U | Influence of an increased intake of linoleic acid on the incorporation of dietary (n-3) fatty acids in phospholipids and on prostanoid synthesis in rat tissues. | 1992 | Biochim. Biophys. Acta | pmid:1450214 |
| Bester R and Lochner A | Sarcolemmal phospholipid fatty acid composition and permeability. | 1988 | Biochim. Biophys. Acta | pmid:3382645 |
| Mizushina Y et al. | The inhibitory action of fatty acids on DNA polymerase beta. | 1997 | Biochim. Biophys. Acta | pmid:9367179 |
| Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
| Schieberle P et al. | A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. | 1981 | Biochim. Biophys. Acta | pmid:6798993 |
| Mizushina Y et al. | Mode analysis of binding of fatty acids to mammalian DNA polymerases. | 2000 | Biochim. Biophys. Acta | pmid:10903472 |
| Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |
| Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
| Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
| Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
| Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
| Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
| Spiteller P et al. | Aldehydic lipid peroxidation products derived from linoleic acid. | 2001 | Biochim. Biophys. Acta | pmid:11325611 |
| Torres-Duarte AP and Vanderhoek JY | Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. | 2003 | Biochim. Biophys. Acta | pmid:12676356 |
| Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |
| Mojumdar EH et al. | Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase. | 2016 | Biochim. Biophys. Acta | pmid:27169629 |
| Jaudszus A et al. | Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. | 2005 | Biochim. Biophys. Acta | pmid:16303327 |
| Breiden B and Sandhoff K | The role of sphingolipid metabolism in cutaneous permeability barrier formation. | 2014 | Biochim. Biophys. Acta | pmid:23954553 |
| Cominacini L et al. | Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. | 1993 | Biochim. Biophys. Acta | pmid:8418885 |
| Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
| Egashira Y et al. | Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression. | 2004 | Biochim. Biophys. Acta | pmid:15522828 |
| Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |
| Elmes M et al. | The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. | 2004 | Biochim. Biophys. Acta | pmid:15522830 |