Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Lactose Intolerance D007787 2 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
D'Angeli S et al. Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. 2013 New Phytol. pmid:23078289
Belury MA et al. Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. 1996 Nutr Cancer pmid:8875552
Nakamura T et al. Excessive fat restriction might promote the recurrence of colorectal tumors. 2010 Nutr Cancer pmid:20099189
Banni S et al. Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. 2001 Nutr Cancer pmid:12094634
Iwamoto S et al. Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. 1998 Nutr Cancer pmid:9770727
Rose DP et al. Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. 1995 Nutr Cancer pmid:7491296
Ip C et al. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. 1995 Nutr Cancer pmid:8610043
Methy N et al. Dietary fatty acids and recurrence of colorectal adenomas in a European intervention trial. 2008 Nutr Cancer pmid:18791918
Johanning GL and Lin TY Unsaturated fatty acid effects on human breast cancer cell adhesion. 1995 Nutr Cancer pmid:7491298
Groscolas R et al. Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. 1995 Nutr Cancer pmid:7491300
Connolly JM et al. Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. 1996 Nutr Cancer pmid:8771566
Ma DW et al. An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. 2002 Nutr Cancer pmid:12734056
Yamasaki M et al. Effect of dietary conjugated linoleic acid on the in vivo growth of rat hepatoma dRLh-84. 2001 Nutr Cancer pmid:11962249
Tokudome S et al. n-6 Polyunsaturated fatty acids and breast cancer. 2003 Nutr Cancer pmid:15087274
Banni S et al. An increase in vitamin A status by the feeding of conjugated linoleic acid. 1999 Nutr Cancer pmid:10227044
Ritskes-Hoitinga J et al. Effects of two dietary fat levels and four dietary linoleic acid levels on mammary tumor development in Balb/c-MMTV mice under ad libitum feeding conditions. 1996 Nutr Cancer pmid:8710685
Ealey KN et al. Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. 2001 Nutr Cancer pmid:12094611
Park HJ et al. Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. 2001 Nutr Cancer pmid:12094615
Lasekan JB et al. Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. 1990 Nutr Cancer pmid:2106675
Wang J et al. Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. 2008 Nutr Cancer pmid:18584483
Josyula S et al. Inhibition of DNA adduct formation of PhIP in female F344 rats by dietary conjugated linoleic acid. 1998 Nutr Cancer pmid:10050262
Josyula S and Schut HA Effects of dietary conjugated linoleic acid on DNA adduct formation of PhIP and IQ after bolus administration to female F344 rats. 1998 Nutr Cancer pmid:10050263
Connolly JM et al. Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. 1999 Nutr Cancer pmid:10624705
Pink RC et al. Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism. 2011 Nutr Cancer pmid:21667399
Degner SC et al. Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. 2007 Nutr Cancer pmid:18001219
Ip C et al. Control of rat mammary epithelium proliferation by conjugated linoleic acid. 2001 Nutr Cancer pmid:11759286
Yang H et al. Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. 2001 Nutr Cancer pmid:11759290
Mackie BS et al. Melanoma and dietary lipids. 1987 Nutr Cancer pmid:3110746
Chajes V et al. Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. 2003 Nutr Cancer pmid:12791500
Aro A et al. Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. 2000 Nutr Cancer pmid:11525591
Kavanaugh CJ et al. Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. 1999 Nutr Cancer pmid:10368807
De Stefani E et al. Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. 2006 Nutr Cancer pmid:17474860
Ip C and Scimeca JA Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. 1997 Nutr Cancer pmid:9121939
Berry EM et al. Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. 1987 Nutr Cancer pmid:3562291
Vasudevan C et al. The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. 2013 Nutr Clin Pract pmid:24177284
Vanek VW et al. A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. 2012 Nutr Clin Pract pmid:22378798
Golfetto I et al. Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? 2007 Nutr Health pmid:18087864
Lasa A et al. The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. 2011 Sep-Oct Nutr Hosp pmid:22072344
Scalerandi MV et al. Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. 2014 Nutr Hosp pmid:24559004
de Luis DA et al. Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. 2011 Jul-Aug Nutr Hosp pmid:22470031
Beezhold BL et al. Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. 2010 Nutr J pmid:20515497
Griel AE et al. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. 2007 Nutr J pmid:17227589
Kim H et al. Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. 2017 Nutr J pmid:28420388
Bongers ME et al. The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. 2007 Nutr J pmid:17428343
McKay DL et al. Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. 2010 Nutr J pmid:20462428
Warensjö E et al. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. 2008 Nutr Metab Cardiovasc Dis pmid:18367385
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Yehuda S and Mostofsky DI The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits. 2004 Nutr Neurosci pmid:15279494
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Yehuda S et al. Mixture of essential fatty acids lowers test anxiety. 2005 Nutr Neurosci pmid:16491653
Tsuyama S et al. Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. 2009 Nutr Neurosci pmid:19622239
Eserian JK et al. Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. 2012 Nutr Neurosci pmid:22390908
Ueda Y et al. Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. 2008 Nutr Res pmid:19083414
Lopes PA et al. Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. 2008 Nutr Res pmid:19083449
Kurotani K et al. High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. 2012 Nutr Res pmid:23084639
Raatz SK et al. Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. 2012 Nutr Res pmid:22260857
Poudel-Tandukar K et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. 2009 Nutr Res pmid:19628101
Martins SV et al. Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids. 2011 Nutr Res pmid:21481719
Angell RJ et al. Fish oil supplementation maintains adequate plasma arachidonate in cats, but similar amounts of vegetable oils lead to dietary arachidonate deficiency from nutrient dilution. 2012 Nutr Res pmid:22652378
Reed S et al. Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). 2014 Nutrients pmid:24658588
Moran LJ et al. Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation. 2016 Nutrients pmid:26742065
Valenzuela R et al. Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. 2015 Nutrients pmid:26247968
Renner L et al. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. 2013 Nutrients pmid:23857174
Ebrahimi M et al. Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. 2014 Nutrients pmid:25255382
Chilton FH et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. 2014 Nutrients pmid:24853887
Fekete K and Decsi T Long-chain polyunsaturated fatty acids in inborn errors of metabolism. 2010 Nutrients pmid:22254065
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385
Lasa A et al. Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. 2011 Nutrition pmid:20619605
Ghosh S et al. Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death. 2004 Nutrition pmid:15474882
Jory J Abnormal fatty acids in Canadian children with autism. 2016 Nutrition pmid:26746679
Aronis A et al. Lipotoxic effects of triacylglycerols in J774.2 macrophages. 2008 Nutrition pmid:18165129
Rodríguez-Cruz M et al. Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. 2009 Nutrition pmid:18849148
Webb AN et al. Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. 2008 Nov-Dec Nutrition pmid:18619813
Burke PA et al. Conditionally essential fatty acid deficiencies in end-stage liver disease. 1999 Nutrition pmid:10319364
Fukushima M et al. Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. 1999 Nutrition pmid:10355850
Hilakivi-Clarke L et al. The influence of maternal diet on breast cancer risk among female offspring. 1999 Nutrition pmid:10355854
Yamasaki M et al. Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. 2003 Nutrition pmid:12507636
Cury-Boaventura MF et al. Comparative toxicity of oleic acid and linoleic acid on Raji cells. 2005 Nutrition pmid:15797684
Stark KD et al. Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. 2002 Jul-Aug Nutrition pmid:12093443
Wolfe RR et al. Dietary fat composition alters pulmonary function in pigs. 2002 Jul-Aug Nutrition pmid:12093447
Rahman SM et al. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. 2001 Nutrition pmid:11377131
Moore CS et al. Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. 2006 Nutrition pmid:17027436
Kim KH and Park HS Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. 2003 Nutrition pmid:12921888
Nagao K et al. The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. 2003 Jul-Aug Nutrition pmid:12831953
Decsi T and Koletzko B Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. 2000 Nutrition pmid:10869902
Peterson DB Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. 1998 Nutrition pmid:9583379
Hargrave KM et al. Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. 2002 Obes. Res. pmid:12490673
Thurmond DC et al. Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. 1993 Obes. Res. pmid:16353349
Miner JL et al. Conjugated linoleic acid (CLA), body fat, and apoptosis. 2001 Obes. Res. pmid:11316347
Hargrave KM et al. Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice. 2004 Obes. Res. pmid:15483208
Dailey MJ et al. Nutrient specific feeding and endocrine effects of jejunal infusions. 2010 Obesity (Silver Spring) pmid:20134410
Pinnick KE et al. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. 2008 Obesity (Silver Spring) pmid:18239594
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. 2012 Obesity (Silver Spring) pmid:22334255
Guyenet SJ High-fat diets: details matter. 2009 Obesity (Silver Spring) pmid:19553921
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Herrera JA et al. Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. 1998 Obstet Gynecol pmid:9540946
Zuo X et al. Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. 2006 Oncogene pmid:16288226
Noguchi M et al. Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). 1995 Nov-Dec Oncology pmid:7478431
Noguchi M et al. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. 1995 Jul-Aug Oncology pmid:7777237