Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Lactose Intolerance D007787 2 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Oh JM et al. Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. 2012 Toxicol In Vitro pmid:22683933
Wolańska D and Kłosiewicz-Latoszek L [Fatty acids intake and serum lipids profile in overweighted and obese adults]. 2012 Rocz Panstw Zakl Hig pmid:22928362
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Montaño M et al. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. 2012 Toxicol. Sci. pmid:22859314
Nandi S et al. Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. 2012 Theriogenology pmid:22115808
Xue C et al. Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. 2012 Lipids pmid:22120618
Ozcan MM et al. Characteristics of grape seed and oil from nine Turkish cultivars. 2012 Nat. Prod. Res. pmid:22132714
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Jung CH et al. The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells. 2012 Inflammation pmid:22124782
Macaluso F et al. Effect of conjugated linoleic acid on testosterone levels in vitro and in vivo after an acute bout of resistance exercise. 2012 J Strength Cond Res pmid:22614148
Joshi S et al. Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. 2012 Org. Biomol. Chem. pmid:22986997
Shah BP et al. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. 2012 Am. J. Physiol., Cell Physiol. pmid:21998136
Saracoglu HT et al. Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. 2012 Nat. Prod. Res. pmid:21870933
Gu L et al. Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure. 2012 Food Chem. Toxicol. pmid:22940538
Rodrigues HG et al. Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. 2012 J. Invest. Dermatol. pmid:21881592
Nurachman Z et al. Oil from the tropical marine benthic-diatom Navicula sp. 2012 Appl. Biochem. Biotechnol. pmid:22926527
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Koch C et al. Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity. 2012 FEBS J. pmid:21920024
Osuji GO et al. Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. 2012 Appl. Biochem. Biotechnol. pmid:22918723
Mukherjee S et al. NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. 2012 J. Biol. Chem. pmid:22923617
Dubey V et al. Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4. 2012 Appl. Biochem. Biotechnol. pmid:22971829
Florence AC et al. Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. 2012 Food Chem pmid:22980792
Gursoy O et al. The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese. 2012 Int J Food Sci Nutr pmid:22166042
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Figueiredo JA et al. Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. 2012 Carbohydr. Res. pmid:22153708
Sajid ZI et al. Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. 2012 Molecules pmid:22466852
Shindo T et al. Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate. 2012 J Toxicol Sci pmid:22467021
Shimomoto T et al. Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. 2012 J. Gastroenterol. pmid:22467055
Zein CO et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. 2012 Hepatology pmid:22505276
Takahashi T et al. Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability. 2012 Reprod. Domest. Anim. pmid:21635578
Liu X et al. Method for screening of bacterial strains biosynthesizing specific conjugated linoleic acid isomers. 2012 J. Agric. Food Chem. pmid:22946615
Eserian JK et al. Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. 2012 Nutr Neurosci pmid:22390908
Fei J et al. ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. 2012 Atherosclerosis pmid:22464285
Jarvis MF Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. 2012 Pain pmid:22681878
Ren HT et al. Influence of dietary fatty acids on muscle fatty acid composition and expression levels of Δ6 desaturase-like and Elovl5-like elongase in common carp (Cyprinus carpio var. Jian). 2012 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:22677415
Angell RJ et al. Fish oil supplementation maintains adequate plasma arachidonate in cats, but similar amounts of vegetable oils lead to dietary arachidonate deficiency from nutrient dilution. 2012 Nutr Res pmid:22652378
Vanek VW et al. A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. 2012 Nutr Clin Pract pmid:22378798
Shin D et al. Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. 2012 Poult. Sci. pmid:22399741
Li KL et al. Characterization of cumulus expansion-inhibiting factor (CEIF) in goat follicles. 2012 Biol. Reprod. pmid:22402961
Dall'Asta C et al. Role of maize hybrids and their chemical composition in Fusarium infection and fumonisin production. 2012 J. Agric. Food Chem. pmid:22409349
Mulligan CM et al. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. 2012 Cardiovasc. Res. pmid:22411972
Gull J et al. Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. 2012 Molecules pmid:22418924
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Chivandi E et al. Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. 2012 Jan-Feb In Vivo pmid:22210722
Alinezhad H et al. Biochemical activities of acetone extracts of Hyssopus angustifolius. 2012 Jul-Aug Acta Pol Pharm pmid:22876603
Moghaddam AH et al. Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. 2012 Jul-Aug Acta Pol Pharm pmid:22876611
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Cheng G et al. Relative validity of a 3 d estimated food record in German toddlers. 2013 Public Health Nutr pmid:22874634
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Moon C et al. Modeling sulfate removal by inhibited mesophilic mixed anaerobic communities using a statistical approach. 2013 Water Res. pmid:23466036
Bae WK et al. Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. 2013 Biomaterials pmid:23174142
Suardíaz R et al. An insight into the regiospecificity of linoleic acid peroxidation catalyzed by mammalian 15-lipoxygenases. 2013 J Phys Chem B pmid:23496802
Cardoso S et al. UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats. 2013 J. Bioenerg. Biomembr. pmid:23504111
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Saubeau G et al. Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. 2013 Plant Cell Rep. pmid:23479199
Song Y et al. Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. 2013 Lipids Health Dis pmid:23879935
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Wei J et al. Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity. 2013 Circ. J. pmid:23883876
Moloney AP et al. Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. 2013 Meat Sci. pmid:23806853
Zhao X et al. Analysis of fatty acids and phytosterols in ethanol extracts of Nelumbo nucifera seeds and rhizomes by GC-MS. 2013 J. Agric. Food Chem. pmid:23742045
Renner L et al. Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. 2013 Nutrients pmid:23857174
Raatz SK et al. Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. 2013 J Acad Nutr Diet pmid:23351633
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Ramsden CE et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. 2013 BMJ pmid:23386268
Zamora-Rojas E et al. Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. 2013 Meat Sci. pmid:23793086
Benjamin S et al. Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. 2013 J Zhejiang Univ Sci B pmid:23365010
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Chiou TY et al. Characteristics and antioxidative ability of defatted rice bran extracts obtained using several extractants under subcritical conditions. 2013 J Oleo Sci pmid:23357811
Warstedt K and Duchén K Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. 2013 Eur J Nutr pmid:22584414
Zlatanov MD et al. Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. 2013 J. Sci. Food Agric. pmid:23174908
McPherson PA et al. Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. 2013 Biochem. Biophys. Res. Commun. pmid:23178466
Serna-Marquez N et al. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. 2013 Cell Oncol (Dordr) pmid:23179791
Gámez-Meza N et al. Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. 2013 J. Sci. Food Agric. pmid:23180465
Toral PG et al. Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. 2013 J. Dairy Sci. pmid:23164228
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Ali Q et al. Ameliorating effects of exogenously applied proline on seed composition, seed oil quality and oil antioxidant activity of maize (Zea mays L.) under drought stress. 2013 Int J Mol Sci pmid:23344043
Benjakul S et al. Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. 2013 Food Sci Technol Int pmid:23729420
Katan MB [Linoleic acid and heart infarct]. 2013 Ned Tijdschr Geneeskd pmid:23714298
Men XM et al. Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. 2013 Animal pmid:23764195
Ndhlala AR et al. Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. 2013 Molecules pmid:23377133
Stelzleni AM et al. Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles. 2013 J. Anim. Sci. pmid:23893987
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Cvetković Z et al. Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin's lymphoma patients. 2013 Med. Oncol. pmid:24085546
Kenny JG et al. Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. 2013 PLoS ONE pmid:23861785
Xie J et al. A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. 2013 Biomed Res Int pmid:23862153
Reinders I et al. Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. 2013 Eur J Clin Nutr pmid:24084512
Gibson RA et al. Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22515943
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
Green DP et al. Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. 2013 Pain pmid:23891895
Ruparel S et al. Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. 2013 Pain pmid:23867730
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Yang Y and McClements DJ Vitamin E and vitamin E acetate solubilization in mixed micelles: physicochemical basis of bioaccessibility. 2013 J Colloid Interface Sci pmid:23768725
Del Mar Bibiloni M et al. Dietary factors associated with subclinical inflammation among girls. 2013 Eur J Clin Nutr pmid:24149444
Layek B and Singh J Cell penetrating peptide conjugated polymeric micelles as a high performance versatile nonviral gene carrier. 2013 Biomacromolecules pmid:24083483
Luo X et al. Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. 2013 Mol. Biol. Rep. pmid:24062071