Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Lactose Intolerance D007787 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Thompson H et al. Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. 1997 Cancer Res. pmid:9371504
Kleinfeld AM et al. Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. 1997 Biochemistry pmid:9369487
Mizushina Y et al. The inhibitory action of fatty acids on DNA polymerase beta. 1997 Biochim. Biophys. Acta pmid:9367179
Singer S et al. Correlation of lipid content and composition with liposarcoma histology and grade. 1997 Oct-Nov Ann. Surg. Oncol. pmid:9367021
Anthony FA et al. Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. 1997 Feb-Apr Photodermatol Photoimmunol Photomed pmid:9361122
Ali I and Steele JE Fatty acids stimulate trehalose synthesis in trophocytes of the cockroach (Periplaneta americana) fat body. 1997 Gen. Comp. Endocrinol. pmid:9356224
O'donnell VB and Kühn H Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. 1997 Biochem. J. pmid:9355754
Yamamoto A et al. Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats. 1997 J Pharm Sci pmid:9344172
Ratnayake WM et al. Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. 1997 J. Pediatr. Gastroenterol. Nutr. pmid:9327370
Meyer C et al. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. 1997 Am. J. Physiol. pmid:9316458
Chatterjee MT et al. Alterations in cellular lipids may be responsible for the transient nature of the yeast heat shock response. 1997 Microbiology (Reading, Engl.) pmid:9308188
Hayakawa F et al. DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. 1997 Biochim. Biophys. Acta pmid:9305782
Moran JH et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. 1997 Toxicol. Appl. Pharmacol. pmid:9299596
Rusnak A et al. Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production. 1997 J. Bioenerg. Biomembr. pmid:9298714
de Waart FG et al. Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. 1997 Atherosclerosis pmid:9298686
Hall JA et al. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. 1997 Jul-Aug J. Vet. Intern. Med. pmid:9298479
López-Nicolás JM et al. Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. 1997 Biochim. Biophys. Acta pmid:9295158
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Usha S and Balakrishnan A c-myc, c-H-ras, and IP3 elevation in 18:2 n-6 dependent proliferation of lung cells. 1997 Jul-Aug In Vitro Cell. Dev. Biol. Anim. pmid:9282304