| MeSH term | MeSH ID | Detail |
|---|---|---|
| Circoviridae Infections | D018173 | 2 associated lipids |
| Spirochaetales Infections | D013145 | 2 associated lipids |
| Lymphopenia | D008231 | 2 associated lipids |
| Genetic Diseases, X-Linked | D040181 | 2 associated lipids |
| Lactose Intolerance | D007787 | 2 associated lipids |
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Makyła K and Paluch M | The linoleic acid influence on molecular interactions in the model of biological membrane. | 2009 | Colloids Surf B Biointerfaces | pmid:19211229 |
| Toyosaki T and Iwabuchi M | New antioxidant protein in seaweed (Porphyra yezoensis Ueda). | 2009 | Int J Food Sci Nutr | pmid:19212859 |
| Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
| Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
| Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
| Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
| Uygun DA et al. | A novel support for antibody purification: fatty acid attached chitosan beads. | 2009 | Colloids Surf B Biointerfaces | pmid:19196498 |
| Carlotti ME et al. | Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. | 2009 | Free Radic. Res. | pmid:19199115 |
| Devillard E et al. | Differences between human subjects in the composition of the faecal bacterial community and faecal metabolism of linoleic acid. | 2009 | Microbiology (Reading, Engl.) | pmid:19202099 |
| Torrecilla JS et al. | Self-organizing maps and learning vector quantization networks as tools to identify vegetable oils. | 2009 | J. Agric. Food Chem. | pmid:19267437 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| Sahoo RR and Biswas SK | Frictional response of fatty acids on steel. | 2009 | J Colloid Interface Sci | pmid:19232636 |
| Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
| Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
| Wempe MF et al. | Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies. | 2009 | J Cosmet Dermatol | pmid:19250169 |
| Kim MH et al. | Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. | 2009 | Cell. Physiol. Biochem. | pmid:19255500 |
| Takata Y et al. | Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. | 2009 | Cancer Causes Control | pmid:19255861 |
| HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
| Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
| Gülçin I | Antioxidant activity of L-adrenaline: a structure-activity insight. | 2009 | Chem. Biol. Interact. | pmid:18929549 |
| Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
| de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
| Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
| RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
| Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
| Saez G et al. | Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks. | 2009 | Br. J. Nutr. | pmid:18616836 |
| Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
| Garscha U and Oliw EH | Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. | 2009 | J. Biol. Chem. | pmid:19289462 |
| Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
| Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
| Angela Liou Y and Innis SM | Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19356914 |
| Raz R et al. | The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. | 2009 | J Child Adolesc Psychopharmacol | pmid:19364294 |
| Nayeem F et al. | Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women. | 2009 | J. Nutr. | pmid:19339706 |
| Inoue N et al. | Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells. | 2009 | J Oleo Sci | pmid:19282639 |
| Fukuda S et al. | Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. | 2009 | PLoS ONE | pmid:19287504 |
| Santillo A et al. | Probiotic in lamb rennet paste enhances rennet lipolytic activity, and conjugated linoleic acid and linoleic acid content in Pecorino cheese. | 2009 | J. Dairy Sci. | pmid:19307614 |
| Zhang D et al. | Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. | 2009 | Plant Physiol. Biochem. | pmid:19217793 |
| Choi NJ et al. | Characterizations of environmental factors in conjugated linoleic acid production by mixed rumen bacteria. | 2009 | J. Agric. Food Chem. | pmid:19754193 |
| Taylor WA and Hatch GM | Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). | 2009 | J. Biol. Chem. | pmid:19737925 |
| Iwamoto N et al. | Antioxidative capacities of durum wheat flour and its components on linoleic acid. | 2009 | J Oleo Sci | pmid:19745581 |
| Queirós B et al. | In search of synergistic effects in antioxidant capacity of combined edible mushrooms. | 2009 | Int J Food Sci Nutr | pmid:19746297 |
| Zhang Y and Wang ZZ | Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. | 2009 | C. R. Biol. | pmid:19748456 |
| Takasuka N et al. | Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. | 2009 | Cancer Lett. | pmid:19028010 |
| Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
| Proudfoot JM et al. | HDL is the major lipoprotein carrier of plasma F2-isoprostanes. | 2009 | J. Lipid Res. | pmid:19050315 |
| Hodson L et al. | Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18940935 |
| Staiger H et al. | Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. | 2009 | Diabetes | pmid:19074989 |
| Sánchez-Campillo M et al. | Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. | 2009 | Food Chem. Toxicol. | pmid:19084569 |
| Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
| Blask DE | Melatonin, sleep disturbance and cancer risk. | 2009 | Sleep Med Rev | pmid:19095474 |
| Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
| Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
| Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Dauchy RT et al. | Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. | 2009 | J. Pineal Res. | pmid:19486272 |
| Yano M et al. | Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. | 2009 | Hepatology | pmid:19492433 |
| Tanaka N et al. | Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice. | 2009 | J. Gastroenterol. | pmid:19506795 |
| Cho CW et al. | Enhanced transdermal delivery of loratadine from the EVA matrix. | 2009 | Drug Deliv | pmid:19514983 |
| Khalili M et al. | Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum. | 2009 | Cell Biol. Int. | pmid:19524695 |
| Damsgaard CT et al. | Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men. | 2009 | J. Nutr. | pmid:19494025 |
| Zhang M et al. | Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. | 2009 | Chem. Biol. Interact. | pmid:19497410 |
| Villa PM et al. | Free fatty acid profiles in preeclampsia. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19497719 |
| Jeng JY et al. | Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19502730 |
| Pinho RS et al. | Potential oilseed crops from the semiarid region of northeastern Brazil. | 2009 | Bioresour. Technol. | pmid:19577461 |
| Finn RD et al. | Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | 2009 | Biochem. J. | pmid:18778245 |
| Guyenet SJ | High-fat diets: details matter. | 2009 | Obesity (Silver Spring) | pmid:19553921 |
| Zhang HM et al. | Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. | 2009 | PLoS ONE | pmid:19557129 |
| Sarikurkcu C et al. | Studies on the antioxidant activity of essential oil and different solvent extracts of Vitexagnuscastus L. fruits from Turkey. | 2009 | Food Chem. Toxicol. | pmid:19595732 |
| Hernández ML et al. | Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19601663 |
| Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
| Zhu X et al. | Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. | 2009 | Chem. Res. Toxicol. | pmid:19537826 |
| Gursoy N et al. | Antioxidant activities, metal contents, total phenolics and flavonoids of seven Morchella species. | 2009 | Food Chem. Toxicol. | pmid:19563856 |
| Goupy P et al. | Antioxidant activity of wine pigments derived from anthocyanins: hydrogen transfer reactions to the dpph radical and inhibition of the heme-induced peroxidation of linoleic acid. | 2009 | J. Agric. Food Chem. | pmid:19566083 |
| Silva-Queiroz SR et al. | PHA(MCL) biosynthesis systems in Pseudomonas aeruginosa and Pseudomonas putida strains show differences on monomer specificities. | 2009 | J. Biotechnol. | pmid:19540884 |
| Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
| Tesoriere L et al. | Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes. | 2009 | Free Radic. Res. | pmid:19548153 |
| Alves BN et al. | Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). | 2009 | Cell Biochem. Funct. | pmid:19548271 |
| Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
| Poudel-Tandukar K et al. | Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. | 2009 | Nutr Res | pmid:19628101 |
| Lee OH et al. | Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. | 2009 | Bioresour. Technol. | pmid:19608415 |
| Fukasawa R et al. | Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. | 2009 | J Oleo Sci | pmid:19430189 |
| Celia C et al. | Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. | 2009 | Colloids Surf B Biointerfaces | pmid:19376689 |
| Evans LM et al. | Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. | 2009 | Clin. Exp. Metastasis | pmid:19267249 |
| Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
| Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |
| Mimoun M et al. | Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. | 2009 | J. Nutr. | pmid:19828687 |
| Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
| Watanabe A et al. | In vitro free radical scavenging activity of platinum nanoparticles. | 2009 | Nanotechnology | pmid:19834242 |
| Hernández-Ledesma B et al. | Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19836349 |
| Shimomura H et al. | Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. | 2009 | FEMS Microbiol. Lett. | pmid:19843309 |
| Chen Q et al. | Generation of fad2 transgenic mice that produce omega-6 fatty acids. | 2009 | Sci. China, C, Life Sci. | pmid:19937203 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Detsi A et al. | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. | 2009 | Bioorg. Med. Chem. | pmid:19853459 |
| Luo J et al. | Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. | 2009 | J Enzyme Inhib Med Chem | pmid:19912062 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activity of Chenpi--compensatory and cooperative actions of ascorbic acid and citric acid. | 2009 | J. UOEH | pmid:20000005 |
| Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
| Grossmann ME et al. | Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. | 2009 | Cancer Prev Res (Phila) | pmid:19789297 |
| Whelan J | The health implications of changing linoleic acid intakes. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990554 |
| Fritsche KL | Too much linoleic acid promotes inflammation-doesn't it? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990555 |
| Adam O et al. | Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973995 |