Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Hulea SA et al. Bilirubin sensitized photooxidation of human plasma low density lipoprotein. 1996 Biochim. Biophys. Acta pmid:8982266
Tsukamoto S et al. Effects of bezafibrate on ethanol oxidation in rats. 1996 Alcohol. Clin. Exp. Res. pmid:8986210
Kinter M et al. Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. 1996 J. Nutr. pmid:9001361
Kubin A et al. Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. 1996 J. Photochem. Photobiol. B, Biol. pmid:9002246
Sheaff Greiner RC et al. Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. 1996 J. Lipid Res. pmid:9017518
Staprans I et al. Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. 1996 J. Lipid Res. pmid:9026539
Hayashi T et al. Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid. 1997 Cancer Lett. pmid:9029175
Cogo PE et al. Simultaneous measurement of the rates of appearance of palmitic and linoleic acid in critically ill infants. 1997 Pediatr. Res. pmid:9029635
Brun T et al. Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. 1997 Diabetes pmid:9032094
Black PN and Sharpe S Dietary fat and asthma: is there a connection? 1997 Eur. Respir. J. pmid:9032484
Solà R et al. Oleic acid rich diet protects against the oxidative modification of high density lipoprotein. 1997 Free Radic. Biol. Med. pmid:9034243
Chen ZY et al. Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. 1997 Am. J. Physiol. pmid:9038989
Gargouri M and Legoy MD The kinetic behaviour of a two-enzyme system in biphasic media: coupling hydrolysis and lipoxygenation. 1997 Biochim. Biophys. Acta pmid:9048899
Das I et al. Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. 1997 Biochem. Soc. Trans. pmid:9056997
Kühn H et al. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. 1997 J. Clin. Invest. pmid:9062346
Roy SK and Kulkarni AP Isolation and some properties of dioxygenase and co-oxidase activities of adult human liver cytosolic lipoxygenase. 1996 J. Biochem. Toxicol. pmid:9062846
Patel RP et al. Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein. 1997 Biochem. J. pmid:9065759
Butler M et al. Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. 1997 Biochem. J. pmid:9065785
Reddy N et al. Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. 1997 Biochem. Biophys. Res. Commun. pmid:9070230
Iwase H et al. Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. 1997 Biochem. Biophys. Res. Commun. pmid:9070266