Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
Otte KB et al. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. 2013 ChemSusChem pmid:23934656
Nakashima R et al. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. 2013 Toxicology pmid:23619606
Huang X et al. Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia. 2013 Clin. Cancer Res. pmid:23493348
Chukir T et al. Shared retronasal identifications of vapor-phase 18-carbon fatty acids. 2013 Chem. Senses pmid:23424022
Anton SD et al. Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. 2013 J Integr Med pmid:23464640
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Sy C et al. Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. 2013 Food Funct pmid:23411789
Salama el-S et al. Biomass, lipid content, and fatty acid composition of freshwater Chlamydomonas mexicana and Scenedesmus obliquus grown under salt stress. 2013 Bioprocess Biosyst Eng pmid:23411874
Tarawneh AH et al. Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans. 2013 J. Agric. Food Chem. pmid:24147790
Girgih AT et al. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. 2013 Plant Foods Hum Nutr pmid:23417711
Lin KH et al. Antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced DNA damage in human lymphocytes. 2013 BMC Res Notes pmid:24279749
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Zuo R et al. Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. 2013 Br. J. Nutr. pmid:23452520
Schneider MR et al. Differentially regulated microRNAs during human sebaceous lipogenesis. 2013 J. Dermatol. Sci. pmid:23452545
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Lind PM et al. An environmental wide association study (EWAS) approach to the metabolic syndrome. 2013 Environ Int pmid:23454278
Emery JA et al. Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. 2013 PLoS ONE pmid:23460861
Lai MC et al. The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas. 2013 J. Vet. Med. Sci. pmid:23832628
Okada Y et al. Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23872318
Klein-Wieringa IR et al. Adipocytes modulate the phenotype of human macrophages through secreted lipids. 2013 J. Immunol. pmid:23817431
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Nakagawa Y [Metabolism and biological function of cardiolipin]. 2013 Yakugaku Zasshi pmid:23649397
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Giua L et al. Oxidative modifications of conjugated and unconjugated linoleic acid during heating. 2013 Food Chem pmid:23692753
Liu Q et al. Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). 2013 Theor. Appl. Genet. pmid:23695179
Khalil WA et al. Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. 2013 Theriogenology pmid:23683689
Le Maux S et al. β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. 2013 J. Dairy Sci. pmid:23684041
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Nørskov NP et al. Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. 2013 J. Proteome Res. pmid:23596967
Jung CH et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. 2013 Metab. Clin. Exp. pmid:23639572
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Carro M et al. Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. 2013 Theriogenology pmid:23273433
Nelson RH et al. Kinetics of saturated, monounsaturated, and polyunsaturated fatty acids in humans. 2013 Diabetes pmid:23274886
Figueroa V et al. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. 2013 Biochim. Biophys. Acta pmid:23261389
Zeng G et al. Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration. 2013 J Phys Chem A pmid:23347186
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Soto-Guzman A et al. Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23332799
Poudyal H et al. Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23333092
Khan AA et al. Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. 2013 Nanomedicine (Lond) pmid:23311988
Graves JP et al. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. 2013 Drug Metab. Dispos. pmid:23315644
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Calder PC Old study sheds new light on the fatty acids and cardiovascular health debate. 2013 BMJ pmid:23386269
Fijlstra M et al. Reduced absorption of long-chain fatty acids during methotrexate-induced gastrointestinal mucositis in the rat. 2013 Clin Nutr pmid:23102689
Toral PG et al. Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. 2013 J. Dairy Sci. pmid:23164228
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Dai J et al. Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. 2013 Lipids Health Dis pmid:23663688
Jemia MB et al. Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). 2013 Nat. Prod. Res. pmid:23082942
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
D'Angeli S et al. Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. 2013 New Phytol. pmid:23078289
Loizzo MR et al. Phenolics, aroma profile, and in vitro antioxidant activity of Italian dessert passito wine from Saracena (Italy). 2013 J. Food Sci. pmid:23574495
Bassett JK et al. Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. 2013 Int. J. Cancer pmid:23575905
Wardhani DH et al. Inhibition kinetics of lipid oxidation of model foods by using antioxidant extract of fermented soybeans. 2013 Food Chem pmid:23561179
Garofalo JM et al. Mouse mammary gland is refractory to the effects of ethanol after natural lactation. 2013 Comp. Med. pmid:23561936
Hein LK et al. Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. 2013 J. Lipid Res. pmid:23564732
Zhao Y et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. 2013 PLoS ONE pmid:23565210
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Shimomura S et al. Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. 2013 Biosci. Biotechnol. Biochem. pmid:23748793
Poon JF et al. In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. 2013 J. Org. Chem. pmid:23701313
Chodok P et al. Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. 2013 J. Ind. Microbiol. Biotechnol. pmid:23702573
de Goede J et al. N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. 2013 PLoS ONE pmid:23741290
Katan MB [Linoleic acid and heart infarct]. 2013 Ned Tijdschr Geneeskd pmid:23714298
Whelan J and Fritsche K Linoleic acid. 2013 Adv Nutr pmid:23674797
Han L et al. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. 2013 Food Chem. Toxicol. pmid:23959106
Aboshi T et al. Biosynthesis of linoleic acid in Tyrophagus mites (Acarina: Acaridae). 2013 Insect Biochem. Mol. Biol. pmid:23973745
Luo C et al. Vegetable oil thermosets reinforced by tannin-lipid formulations. 2013 Acta Biomater pmid:22975626
Ramirez AM et al. A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. 2013 Lipids pmid:23893337
Adachi S et al. Increased levels of extracellular dopamine in the nucleus accumbens and amygdala of rats by ingesting a low concentration of a long-chain Fatty Acid. 2013 Biosci. Biotechnol. Biochem. pmid:24200795
Kummerow FA et al. Effects of trans fats on prostacyclin production. 2013 Scand. Cardiovasc. J. pmid:24228623
Özcan T Accumulation patterns of some seed oil components from wild sources of Turkey. 2013 Nat. Prod. Res. pmid:22233192
Herrera-Meza MS et al. Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. 2013 Int J Food Sci Nutr pmid:23360131
Satoh K Linoleic acid. A novel mechanism of endothelial cell dysfunction. 2013 Circ. J. pmid:24077059
Li KC et al. [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. 2013 Zhonghua Gan Zang Bing Za Zhi pmid:24025140
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Risé P et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23910046
Le Maux S et al. Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. 2013 Food Chem pmid:23870962
Aladedunye F and Przybylski R Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. 2013 Food Chem pmid:23870970
Chen CS et al. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24154509
Smink W et al. Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. 2013 J Anim Physiol Anim Nutr (Berl) pmid:22463497
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Benbrook CM et al. Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. 2013 PLoS ONE pmid:24349282
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Li P et al. Effect of non-esterified fatty acids on fatty acid metabolism-related genes in calf hepatocytes cultured in vitro. 2013 Cell. Physiol. Biochem. pmid:24335176
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Ngakegni-Limbili AC et al. Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. 2013 J. Sci. Food Agric. pmid:22692978
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639
De Weirdt R et al. A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. 2013 Benef Microbes pmid:24311313
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Okada Y et al. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. 2013 Clin. Exp. Immunol. pmid:24028683
Vukašinović EL et al. Diapause induces changes in the composition and biophysical properties of lipids in larvae of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae). 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23701990
Luo X et al. Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. 2013 Mol. Biol. Rep. pmid:24062071