Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Green P et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. 1990 Am. J. Clin. Nutr. pmid:2239789
Akamatsu H et al. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. 1990 J. Invest. Dermatol. pmid:2143521
Piché LA and Mahadevappa VG Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. 1990 J. Nutr. pmid:2111377
Hernández-Caselles T et al. Stability of liposomes on long term storage. 1990 J. Pharm. Pharmacol. pmid:1979618
Kim D and Duff RA Regulation of K+ channels in cardiac myocytes by free fatty acids. 1990 Circ. Res. pmid:2119911
Laugier C et al. Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. 1991 Biochem. Biophys. Res. Commun. pmid:1645959
Saddik M and Lopaschuk GD The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. 1991 Biochim. Biophys. Acta pmid:1932104
Shultz TD Physiological free fatty acid concentrations do not increase free estradiol in plasma. 1991 J. Clin. Endocrinol. Metab. pmid:1986028
Hrboticky N et al. Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. 1991 Am. J. Clin. Nutr. pmid:1989416
Kearns EV et al. The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). 1991 Arch. Biochem. Biophys. pmid:1989527
Hou SY et al. Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. 1991 J. Invest. Dermatol. pmid:1991982
Muakkassa FF et al. Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. 1991 Arch Surg pmid:1992995
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Hubbard NE and Erickson KL Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. 1991 Cancer Lett. pmid:1998946
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
Andrianarison RH et al. Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. 1991 Biochem. Biophys. Res. Commun. pmid:1953704
Takamura H et al. Inhibition by lipoxygenase-3 of n-hexanal generation in soybeans. 1991 FEBS Lett. pmid:1959624
Boor PJ et al. Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. 1991 J. Am. Coll. Cardiol. pmid:1960335
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
Gerwick WH et al. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. 1991 Arch. Biochem. Biophys. pmid:1929410
Ip C et al. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. 1991 Cancer Res. pmid:1933874
Fukuzawa K et al. Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. 1991 Arch. Biochem. Biophys. pmid:1656881
Butovich IA et al. The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. 1991 Eur. J. Biochem. pmid:2065670
Rose DP and Connolly JM Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. 1991 Prostate pmid:2020620
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Izumi T et al. Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. 1991 Eur. J. Biochem. pmid:1662607
Stein Y et al. Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. 1991 Biochim. Biophys. Acta pmid:2054378
Nagao M et al. Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes. 1991 J. Orthop. Res. pmid:1901357
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Liu B et al. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. 1991 Cell Regul. pmid:1801923
Rainey PM et al. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. 1991 Mol. Biochem. Parasitol. pmid:1775152
Katan MB et al. Biological markers of dietary intake, with emphasis on fatty acids. 1991 Ann. Nutr. Metab. pmid:1776820
Sarkar G Beneficial ghee? 1991 Nature pmid:1876181
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. 1991 Poult. Sci. pmid:1784570
Pourplanche C et al. Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. 1991 Anal. Biochem. pmid:1789419
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Jyothirmayi N and Ramadoss CS Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. 1991 Biochim. Biophys. Acta pmid:1903659
Uchida Y et al. Enhancement of keratin synthesis induced by lipokeratinogenoside, N-(O-linoleoyl)-omega-hydroxy fatty acyl sphingosyl glucose, in association with alteration of the intracellular Ca(2+)-content and protein kinase in cultured keratinocytes (FRSK). 1991 J. Biochem. pmid:1715342
Leyton J et al. Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. 1991 Cancer Res. pmid:1899048
Iacono JM and Dougherty RM Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. 1991 Am. J. Clin. Nutr. pmid:1900384
Macías P et al. Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. 1991 Biochim. Biophys. Acta pmid:1903070
Iwahashi H et al. Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. 1991 Arch. Biochem. Biophys. pmid:1846731
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Ramasamy S et al. Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. 1991 J. Biochem. Toxicol. pmid:1831858
Semplicini A et al. Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. 1991 J Hypertens Suppl pmid:1818979
Burri BJ et al. Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. 1991 Am. J. Clin. Nutr. pmid:1858699
Bell JG et al. High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. 1991 J. Nutr. pmid:1861166
DaTorre SD and Creer MH Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. 1991 J. Lipid Res. pmid:1940640
James DR et al. Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis. 1991 Clin. Chim. Acta pmid:1819470
Nègre-Salvayre A et al. Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin. 1991 Pharmacology pmid:1652140
Iwado H et al. Mutagenicity and antimutagenicity of air-borne particulates. 1991 Mutat. Res. pmid:1986270
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Hollander D and Tarnawski A Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection? 1991 J. Clin. Gastroenterol. pmid:1940200
Baer AN et al. Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales. 1991 J. Lipid Res. pmid:1906083
Nemecz G et al. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. 1991 Arch. Biochem. Biophys. pmid:1897956
Owen S et al. Evidence of free-radical activity in asthma. 1991 N. Engl. J. Med. pmid:1857396
Julu PO and Mutamba A Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. 1991 J. Neurol. Sci. pmid:1663993
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Dyer JR and Greenwood CE Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. 1991 J. Neurochem. pmid:1673995
Biagi PL et al. Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. 1991 Biochim. Biophys. Acta pmid:1674661
Naidu AK et al. Aldrin epoxidation. Catalytic potential of lipoxygenase coupled with linoleic acid oxidation. 1991 Jul-Aug Drug Metab. Dispos. pmid:1680652
Herzberg GR et al. Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. 1992 Biochim. Biophys. Acta pmid:1531932
Hui R et al. Inhibition of vasopressin-induced formation of diradylglycerols in vascular smooth muscle cells by incorporation of eicosapentaenoic acid in membrane phospholipids. 1992 J. Hypertens. pmid:1334995
Mensink RP et al. Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. 1992 J. Lipid Res. pmid:1431574
Kilsdonk EP et al. Effect of phospholipid fatty acid composition of endothelial cells on cholesterol efflux rates. 1992 J. Lipid Res. pmid:1402404
Girelli D et al. Red blood cells and platelet membrane fatty acids in non-dialyzed and dialyzed uremics. 1992 Clin. Chim. Acta pmid:1458610
Jannace PW et al. Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. 1992 Am. J. Clin. Nutr. pmid:1323926
Winterbourn CC et al. Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. 1992 Arch. Biochem. Biophys. pmid:1321589
Sauer LA and Dauchy RT Uptake of plasma lipids by tissue-isolated hepatomas 7288CTC and 7777 in vivo. 1992 Br. J. Cancer pmid:1503901
Uden S et al. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. 1992 Aliment. Pharmacol. Ther. pmid:1600043
Bonanome A et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. 1992 Arterioscler. Thromb. pmid:1558840
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Leaf AA et al. Factors affecting long-chain polyunsaturated fatty acid composition of plasma choline phosphoglycerides in preterm infants. 1992 J. Pediatr. Gastroenterol. Nutr. pmid:1535657
Imagawa W et al. Pregnancy-dependent to ovarian-independent progression in mammary tumors delineated in primary culture: changes in signal transduction, growth factor regulation, and matrix interaction. 1992 Cancer Res. pmid:1330295
Glasgow WC et al. Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. 1992 J. Biol. Chem. pmid:1587852
Allgayer H et al. Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. 1992 Biochem. Pharmacol. pmid:1310851
Albro PW et al. Isolation and characterization of the initial radical adduct formed from linoleic acid and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone in the presence of soybean lipoxygenase. 1992 Chem. Biol. Interact. pmid:1312396
Kalyanaraman B et al. Synergistic interaction between the probucol phenoxyl radical and ascorbic acid in inhibiting the oxidation of low density lipoprotein. 1992 J. Biol. Chem. pmid:1313022
Garfinkel M et al. Insulinotropic potency of lauric acid: a metabolic rationale for medium chain fatty acids (MCF) in TPN formulation. 1992 J. Surg. Res. pmid:1593871
Kang JX et al. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. 1992 Biochem. J. pmid:1323271
Spitz DR et al. The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells. 1992 Pediatr. Res. pmid:1408477
Vilchez C et al. Research note: eggshell quality in Japanese quail fed different fatty acids. 1992 Poult. Sci. pmid:1409241
Shao Z and Mitra AK Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport. 1992 Pharm. Res. pmid:1409402
Wang PF and Zheng RL Inhibitions of the autoxidation of linoleic acid by flavonoids in micelles. 1992 Chem. Phys. Lipids pmid:1486658
Koba K et al. Effects of alpha-tocopherol and tocotrienols on blood pressure and linoleic acid metabolism in the spontaneously hypertensive rat (SHR). 1992 Biosci. Biotechnol. Biochem. pmid:1368948
Raederstorff D and Moser U Influence of an increased intake of linoleic acid on the incorporation of dietary (n-3) fatty acids in phospholipids and on prostanoid synthesis in rat tissues. 1992 Biochim. Biophys. Acta pmid:1450214
Duthie GG et al. Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. 1992 Arch. Biochem. Biophys. pmid:1632646
Yin D et al. Fenton reagents may not initiate lipid peroxidation in an emulsified linoleic acid model system. 1992 Free Radic. Biol. Med. pmid:1459478
Fotouhi N and Jenkins TC Ruminal biohydrogenation of linoleoyl methionine and calcium linoleate in sheep. 1992 J. Anim. Sci. pmid:1459921
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 2. Maternal diets and stage of incubation on the lipid metabolism of quail embryos. 1992 Poult. Sci. pmid:1614943
Mori TA et al. Differential effect of aspirin on platelet aggregation in IDDM. 1992 Diabetes pmid:1551486
Doderer A et al. Purification and characterization of two lipoxygenase isoenzymes from germinating barley. 1992 Biochim. Biophys. Acta pmid:1554746
Keler T et al. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1594582
Ziylan ZY et al. Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, alpha-aminoisobutyric acid and phenylalanine in the rat. 1992 Neurosci. Lett. pmid:1625821
Auerbach BJ et al. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. 1992 Anal. Biochem. pmid:1632527
Brightman AO et al. A growth factor- and hormone-stimulated NADH oxidase from rat liver plasma membrane. 1992 Biochim. Biophys. Acta pmid:1567890