| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Coronary Syndrome | D054058 | 11 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Genetic Diseases, X-Linked | D040181 | 2 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Restenosis | D023903 | 10 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Circoviridae Infections | D018173 | 2 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Community-Acquired Infections | D017714 | 8 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson GH and Fritsche K | Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials. | 2012 | J Acad Nutr Diet | pmid:22889633 |
| Oh JM et al. | Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. | 2012 | Toxicol In Vitro | pmid:22683933 |
| Chiou TY et al. | Extraction of defatted rice bran with subcritical aqueous acetone. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878207 |
| Wolańska D and Kłosiewicz-Latoszek L | [Fatty acids intake and serum lipids profile in overweighted and obese adults]. | 2012 | Rocz Panstw Zakl Hig | pmid:22928362 |
| Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
| Honkanen AM et al. | Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. | 2012 | J. Dairy Sci. | pmid:22365221 |
| Montaño M et al. | New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. | 2012 | Toxicol. Sci. | pmid:22859314 |
| Jadoon A et al. | Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. | 2012 | J Affect Disord | pmid:22113178 |
| Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
| Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
| Gutla PV et al. | Modulation of plant TPC channels by polyunsaturated fatty acids. | 2012 | J. Exp. Bot. | pmid:23105130 |
| Xue C et al. | Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. | 2012 | Lipids | pmid:22120618 |
| Jernerén F et al. | Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. | 2012 | Lipids | pmid:22048860 |
| Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
| Rohr-Udilova N et al. | Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. | 2012 | Hepatology | pmid:22105228 |
| Ebba S et al. | The examination of fatty acid taste with edible strips. | 2012 | Physiol. Behav. | pmid:22521910 |
| Ozcan MM et al. | Characteristics of grape seed and oil from nine Turkish cultivars. | 2012 | Nat. Prod. Res. | pmid:22132714 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Jung CH et al. | The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells. | 2012 | Inflammation | pmid:22124782 |
| Ruparel S et al. | Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. | 2012 | Pain | pmid:22633978 |
| Jarret RL and Levy IJ | Oil and fatty acid contents in seed of Citrullus lanatus Schrad. | 2012 | J. Agric. Food Chem. | pmid:22540530 |
| Dramane G et al. | STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. | 2012 | J. Clin. Invest. | pmid:22546859 |
| Macaluso F et al. | Effect of conjugated linoleic acid on testosterone levels in vitro and in vivo after an acute bout of resistance exercise. | 2012 | J Strength Cond Res | pmid:22614148 |
| Naqvi AZ et al. | Dietary fatty acids and peripheral artery disease in adults. | 2012 | Atherosclerosis | pmid:22552117 |
| Banti CN et al. | Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. | 2012 | Metallomics | pmid:22552402 |
| Joshi S et al. | Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | 2012 | Org. Biomol. Chem. | pmid:22986997 |
| Dubé E et al. | Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. | 2012 | Biol. Reprod. | pmid:22553224 |
| Li J et al. | A chitosan induced 9-lipoxygenase in Adelostemma gracillimum seedlings. | 2012 | Int J Mol Sci | pmid:22312270 |
| Perdriau S et al. | Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. | 2012 | ChemSusChem | pmid:23060315 |
| O'Donnell-Megaro AM et al. | Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. | 2012 | J. Dairy Sci. | pmid:23063161 |
| Krugner-Higby L et al. | Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. | 2012 | Comp. Med. | pmid:23043777 |
| Coimbra MC and Jorge N | Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). | 2012 | J. Sci. Food Agric. | pmid:21922463 |
| Han SN et al. | Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. | 2012 | J. Nutr. | pmid:23096013 |
| Shah BP et al. | TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:21998136 |
| Marincola FC et al. | A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. | 2012 | J. Matern. Fetal. Neonatal. Med. | pmid:23025771 |
| Kanter JE et al. | Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. | 2012 | Biochim. Biophys. Acta | pmid:22020260 |
| Poompachee K and Chudapongse N | Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. | 2012 | Med Princ Pract | pmid:22024634 |
| Saracoglu HT et al. | Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. | 2012 | Nat. Prod. Res. | pmid:21870933 |
| Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. | 2012 | Obesity (Silver Spring) | pmid:22334255 |
| Lee S et al. | Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. | 2012 | Br. J. Nutr. | pmid:21846428 |
| de Goede J et al. | Linoleic acid intake, plasma cholesterol and 10-year incidence of CHD in 20,000 middle-aged men and women in the Netherlands. | 2012 | Br. J. Nutr. | pmid:21816117 |
| Sun X et al. | Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake. | 2012 | Int. J. Cancer | pmid:22322480 |
| Matesanz N et al. | Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms. | 2012 | J. Nutr. Biochem. | pmid:21840193 |
| Gu L et al. | Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure. | 2012 | Food Chem. Toxicol. | pmid:22940538 |
| Sandoval-Montemayor NE et al. | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | 2012 | Molecules | pmid:22992784 |
| Rodrigues HG et al. | Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. | 2012 | J. Invest. Dermatol. | pmid:21881592 |
| Nurachman Z et al. | Oil from the tropical marine benthic-diatom Navicula sp. | 2012 | Appl. Biochem. Biotechnol. | pmid:22926527 |
| Huang FC and Schwab W | Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. | 2012 | Plant Biotechnol. J. | pmid:22967031 |
| de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
| Koch C et al. | Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity. | 2012 | FEBS J. | pmid:21920024 |
| Osuji GO et al. | Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. | 2012 | Appl. Biochem. Biotechnol. | pmid:22918723 |
| Kim YS et al. | In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. | 2012 | Food Chem. Toxicol. | pmid:22921350 |
| Mukherjee S et al. | NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. | 2012 | J. Biol. Chem. | pmid:22923617 |
| Le Maux S et al. | β-Lactoglobulin as a molecular carrier of linoleate: characterization and effects on intestinal epithelial cells in vitro. | 2012 | J. Agric. Food Chem. | pmid:22924475 |
| Dubey V et al. | Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4. | 2012 | Appl. Biochem. Biotechnol. | pmid:22971829 |
| Florence AC et al. | Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. | 2012 | Food Chem | pmid:22980792 |
| Gursoy O et al. | The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese. | 2012 | Int J Food Sci Nutr | pmid:22166042 |
| Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
| Levitan EB et al. | α-Linolenic acid, linoleic acid and heart failure in women. | 2012 | Br. J. Nutr. | pmid:22172525 |
| Taârit MB et al. | Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. | 2012 | J. Sci. Food Agric. | pmid:22173568 |
| Figueiredo JA et al. | Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. | 2012 | Carbohydr. Res. | pmid:22153708 |
| Byun HJ et al. | Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. | 2012 | J. Dermatol. Sci. | pmid:22209282 |
| Cheguru P et al. | Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. | 2012 | Pflugers Arch. | pmid:22218833 |
| Beevi SS et al. | Polyphenolics profile and antioxidant properties of Raphanus sativus L. | 2012 | Nat. Prod. Res. | pmid:21714734 |
| Sajid ZI et al. | Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. | 2012 | Molecules | pmid:22466852 |
| Shindo T et al. | Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate. | 2012 | J Toxicol Sci | pmid:22467021 |
| Shimomoto T et al. | Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. | 2012 | J. Gastroenterol. | pmid:22467055 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
| Zein CO et al. | Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. | 2012 | Hepatology | pmid:22505276 |
| Takahashi T et al. | Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability. | 2012 | Reprod. Domest. Anim. | pmid:21635578 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
| Liu X et al. | Method for screening of bacterial strains biosynthesizing specific conjugated linoleic acid isomers. | 2012 | J. Agric. Food Chem. | pmid:22946615 |
| Eserian JK et al. | Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | 2012 | Nutr Neurosci | pmid:22390908 |
| Fei J et al. | ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. | 2012 | Atherosclerosis | pmid:22464285 |
| Steffen BT et al. | Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. | 2012 | Int J Obes (Lond) | pmid:21829163 |
| Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
| Jarvis MF | Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. | 2012 | Pain | pmid:22681878 |
| Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
| Wu J et al. | Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. | 2012 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:22687573 |
| Reynolds CM et al. | Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. | 2012 | Mol Nutr Food Res | pmid:22700321 |
| de Freitas JM et al. | Influence of cellular fatty acid composition on the response of Saccharomyces cerevisiae to hydrostatic pressure stress. | 2012 | FEMS Yeast Res. | pmid:22846157 |
| Ren HT et al. | Influence of dietary fatty acids on muscle fatty acid composition and expression levels of Δ6 desaturase-like and Elovl5-like elongase in common carp (Cyprinus carpio var. Jian). | 2012 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:22677415 |
| Angell RJ et al. | Fish oil supplementation maintains adequate plasma arachidonate in cats, but similar amounts of vegetable oils lead to dietary arachidonate deficiency from nutrient dilution. | 2012 | Nutr Res | pmid:22652378 |
| Burrows T et al. | A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids. | 2012 | Eur J Clin Nutr | pmid:22378224 |
| Vanek VW et al. | A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. | 2012 | Nutr Clin Pract | pmid:22378798 |
| Shin D et al. | Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. | 2012 | Poult. Sci. | pmid:22399741 |
| Khan R et al. | Variation in oil content and fatty acid composition of the seed oil of Acacia species collected from the northwest zone of India. | 2012 | J. Sci. Food Agric. | pmid:22351513 |
| Chen MH and Nelson EB | Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. | 2012 | Phytopathology | pmid:22352306 |
| Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
| Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
| He M et al. | Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. | 2012 | J. Dairy Sci. | pmid:22365227 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Li KL et al. | Characterization of cumulus expansion-inhibiting factor (CEIF) in goat follicles. | 2012 | Biol. Reprod. | pmid:22402961 |
| Dall'Asta C et al. | Role of maize hybrids and their chemical composition in Fusarium infection and fumonisin production. | 2012 | J. Agric. Food Chem. | pmid:22409349 |
| Mulligan CM et al. | Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. | 2012 | Cardiovasc. Res. | pmid:22411972 |
| Gull J et al. | Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. | 2012 | Molecules | pmid:22418924 |
| Sultana B et al. | Investigation on the antioxidant activity of leaves, peels, stems bark, and kernel of mango (Mangifera indica L.). | 2012 | J. Food Sci. | pmid:22860576 |
| Wakabayashi K et al. | Species differences in toxicokinetic parameters of glycidol after a single dose of glycidol or glycidol linoleate in rats and monkeys. | 2012 | J Toxicol Sci | pmid:22863850 |