| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Randich A et al. | Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14660477 |
| Whigham LD et al. | CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171673 |
| Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
| Chen CS et al. | Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24154509 |
| Darling RA et al. | Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24760994 |
| Zhou Y et al. | UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28424210 |
| Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
| Houston M et al. | Oxidized linoleic acid regulates expression and shedding of syndecan-4. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15469957 |
| Suh HN et al. | Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18842827 |
| Shah BP et al. | TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:21998136 |
| González-AbuÃn N et al. | Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24371039 |
| McKay MC and Worley JF | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546665 |
| Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
| Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
| Hill EM et al. | Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9569236 |
| Cavicchioli P et al. | Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208626 |
| Graczyk TK and Shiff CJ | Recovery of avian schistosome cercariae from water using penetration stimulant matrix with an unsaturated fatty acid. | 2000 Sep-Oct | Am. J. Trop. Med. Hyg. | pmid:11388510 |
| Mpagi JL et al. | Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. | 2000 | Am. J. Trop. Med. Hyg. | pmid:11304059 |
| Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
| Shen Q et al. | Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. | 2010 | Anaerobe | pmid:20601030 |
| Wang YL et al. | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. | 2005 | Anal Bioanal Chem | pmid:16132135 |
| Ito J et al. | A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. | 2016 | Anal Bioanal Chem | pmid:27549797 |
| Tao X et al. | GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. | 2008 | Anal Bioanal Chem | pmid:18622754 |
| Billault I et al. | Probing substrate-product relationships by natural abundance deuterium 2D NMR spectroscopy in liquid-crystalline solvents: epoxidation of linoleate to vernoleate by two different plant enzymes. | 2012 | Anal Bioanal Chem | pmid:22349323 |
| Wejnerowska G et al. | Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. | 2008 | Anal Sci | pmid:18544865 |
| Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
| KOKATNUR MG et al. | A RAPID METHOD FOR THE PREPARATION OF PEROXIDES FROM AUTOXIDIZED METHYL ESTERS OF FATTY ACIDS. | 1965 | Anal. Biochem. | pmid:14340025 |
| López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
| Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
| Kotani A et al. | Determination of plasma free fatty acids by high-performance liquid chromatography with electrochemical detection. | 2000 | Anal. Biochem. | pmid:10933857 |
| Liu X et al. | Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. | 2013 | Anal. Biochem. | pmid:23850559 |
| KOEHLER WR et al. | A METHOD FOR SEPARATING SATURATED FATTY ACID ESTERS FROM UNSATURATED ESTERS FOR GAS CHROMATOGRAPHIC ANALYSIS. | 1964 | Anal. Biochem. | pmid:14213999 |
| Pourplanche C et al. | Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. | 1991 | Anal. Biochem. | pmid:1789419 |
| Andre JC and Funk MO | Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. | 1986 | Anal. Biochem. | pmid:3101541 |
| Oliw EH et al. | Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. | 2006 | Anal. Biochem. | pmid:16712763 |
| Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
| Auerbach BJ et al. | A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. | 1992 | Anal. Biochem. | pmid:1632527 |
| PINTER KG et al. | QUANTITATIVE DETERMINATION OF SERUM TRIGLYCERIDES BY GLASS-FIBER PAPER CHROMATOGRAPHY. | 1964 | Anal. Biochem. | pmid:14186669 |
| Waddington E et al. | Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. | 2001 | Anal. Biochem. | pmid:11355856 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
| Zeng YX et al. | Comparative analysis of volatile components from Clematis species growing in China. | 2007 | Anal. Chim. Acta | pmid:17606017 |
| P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
| Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
| Kreich M and Claus P | Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16315163 |
| O'Quinn PR et al. | Conjugated linoleic acid. | 2000 | Anim Health Res Rev | pmid:11706843 |
| McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
| Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
| Shibata H et al. | Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. | 2011 | Anim. Sci. J. | pmid:21794014 |
| Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |