| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Buchanan MR et al. | 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. | 1985 | J. Biol. Chem. | pmid:3934168 |
| Kharasch ED and Novak RF | Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. | 1985 | J. Biol. Chem. | pmid:2993283 |
| Hansen HS and Jensen B | Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. | 1985 | Biochim. Biophys. Acta | pmid:3922424 |
| Ip C et al. | Requirement of essential fatty acid for mammary tumorigenesis in the rat. | 1985 | Cancer Res. | pmid:3921234 |
| Canfield LM et al. | Anti-oxidant/pro-oxidant reactions of vitamin K. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985964 |
| Válek J et al. | Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. | 1985 | Atherosclerosis | pmid:3994777 |
| Tsuchida M et al. | Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. | 1985 | Biochim. Biophys. Acta | pmid:3995061 |
| Robinson M et al. | Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. | 1985 | J. Biol. Chem. | pmid:4008481 |
| Montalto MB et al. | Nutrient intakes of formula-fed infants and infants fed cow's milk. | 1985 | Pediatrics | pmid:3969338 |
| Jett M et al. | Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. | 1985 | Cancer Res. | pmid:4027970 |
| Hennig B et al. | Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. | 1985 | Circ. Res. | pmid:4053308 |
| Barclay LR et al. | The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. | 1985 | J. Biol. Chem. | pmid:4066696 |
| Clark DL and Queener SF | Effects of diabetes mellitus on renal fatty acid activation and desaturation. | 1985 | Biochem. Pharmacol. | pmid:4074391 |
| Isseroff RR et al. | Alterations in fatty acid composition of murine keratinocytes with in vitro cultivation. | 1985 | J. Invest. Dermatol. | pmid:3926903 |
| Giamalva D et al. | A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084297 |
| Fusco AC et al. | Schistosoma mansoni: eicosanoid production by cercariae. | 1985 | Exp. Parasitol. | pmid:3917929 |
| Jones PJ et al. | Whole body oxidation of dietary fatty acids: implications for energy utilization. | 1985 | Am. J. Clin. Nutr. | pmid:3933323 |
| Farrell PM et al. | Fatty acid abnormalities in cystic fibrosis. | 1985 | Pediatr. Res. | pmid:3918287 |
| Stoeck M et al. | Studies on the mechanism whereby cyclosporin A inhibits T-lymphocyte activation. | 1985 | Immunobiology | pmid:2580777 |
| Boberg M et al. | Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. | 1985 | Clin. Sci. | pmid:3919990 |
| Erskine KJ et al. | An altered ratio of 18:2 (9,11) to 18:2 (9,12) linoleic acid in plasma phospholipids as a possible predictor of pre-eclampsia. | 1985 | Lancet | pmid:2857904 |
| Salzmann-Reinhardt U et al. | Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. | 1985 | Eur. J. Biochem. | pmid:3933978 |
| Burton AF and Anderson FH | Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. | 1985 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3839859 |
| Andersen GE et al. | Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants. | 1985 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:3934403 |
| Gotoh K et al. | Effects of unsaturated fatty acids on the peroxisomal enzyme activities of Tetrahymena pyriformis. | 1986 | J. Biochem. | pmid:2880840 |
| Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
| Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
| Murphy MG | Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma. | 1986 | J. Neurochem. | pmid:3011993 |
| Skogh M | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids) | 1986 | J. Am. Acad. Dermatol. | pmid:3013957 |
| Kelly RA et al. | Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids. | 1986 | J. Biol. Chem. | pmid:3017943 |
| Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
| Stymne S and Stobart AK | Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). | 1986 | Biochem. J. | pmid:3028375 |
| De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
| Fressinaud C et al. | Fatty acid composition of endoneurium and perineurium from adult rat sciatic nerve. | 1986 | J. Neurochem. | pmid:3958717 |
| Kort WJ et al. | Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. | 1986 | Ann. Nutr. Metab. | pmid:3963748 |
| Heagerty AM et al. | Influence of dietary linoleic acid on leucocyte sodium transport and blood pressure. | 1986 | Br Med J (Clin Res Ed) | pmid:3089491 |
| Ng LL and Hockaday TD | Influence of dietary linoleic acid on leucocyte sodium transport and blood pressure. | 1986 | Br Med J (Clin Res Ed) | pmid:3092960 |
| Feingold KR et al. | Effect of essential fatty acid deficiency on cutaneous sterol synthesis. | 1986 | J. Invest. Dermatol. | pmid:3772153 |
| Jones DB et al. | Indirect evidence of impairment of platelet desaturase enzymes in diabetes mellitus. | 1986 | Horm. Metab. Res. | pmid:3013745 |
| Kukreja RC et al. | PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. | 1986 | Circ. Res. | pmid:3028671 |
| Wertz PW and Downing DT | Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice. | 1986 | Biochim. Biophys. Acta | pmid:3707979 |
| Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
| Awad AB and Chattopadhyay JP | Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. | 1986 | J. Nutr. | pmid:3723204 |
| Leikin AI and Brenner RR | Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. | 1986 | Biochim. Biophys. Acta | pmid:2869785 |
| Carlson SE et al. | High fat diets varying in ratios of polyunsaturated to saturated fatty acid and linoleic to linolenic acid: a comparison of rat neural and red cell membrane phospholipids. | 1986 | J. Nutr. | pmid:2871142 |
| Elliott GR et al. | Linoleic and dihomo-gamma-linolenic acids modulate granuloma growth and granuloma macrophage eicosanoid release. | 1986 | Eur. J. Pharmacol. | pmid:3460810 |
| Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
| Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
| Murakami K et al. | Protein kinase C activation by cis-fatty acid in the absence of Ca2+ and phospholipids. | 1986 | J. Biol. Chem. | pmid:3096987 |
| Stewart ME et al. | Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. | 1986 | J. Invest. Dermatol. | pmid:2946783 |