Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Johnson GH and Fritsche K Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials. 2012 J Acad Nutr Diet pmid:22889633
Oh JM et al. Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. 2012 Toxicol In Vitro pmid:22683933
Chiou TY et al. Extraction of defatted rice bran with subcritical aqueous acetone. 2012 Biosci. Biotechnol. Biochem. pmid:22878207
Virtanen JK et al. Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. 2012 Osteoporos Int pmid:22270860
Sabir A et al. The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties (Vitis spp.). 2012 J. Sci. Food Agric. pmid:22271548
Ross GR et al. Fatty acid profile of pig meat after probiotic administration. 2012 J. Agric. Food Chem. pmid:22506842
Morales A et al. Quantitative analysis of hydroperoxy-, keto- and hydroxy-dienes in refined vegetable oils. 2012 J Chromatogr A pmid:22321954
Wolańska D and Kłosiewicz-Latoszek L [Fatty acids intake and serum lipids profile in overweighted and obese adults]. 2012 Rocz Panstw Zakl Hig pmid:22928362
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Honkanen AM et al. Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. 2012 J. Dairy Sci. pmid:22365221
Montaño M et al. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. 2012 Toxicol. Sci. pmid:22859314
Jadoon A et al. Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. 2012 J Affect Disord pmid:22113178
Järvinen R et al. Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. 2012 Eur J Clin Nutr pmid:22113249
Bonacci G et al. Conjugated linoleic acid is a preferential substrate for fatty acid nitration. 2012 J. Biol. Chem. pmid:23144452
Nandi S et al. Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. 2012 Theriogenology pmid:22115808
Gutla PV et al. Modulation of plant TPC channels by polyunsaturated fatty acids. 2012 J. Exp. Bot. pmid:23105130
Xue C et al. Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. 2012 Lipids pmid:22120618
Jernerén F et al. Linolenate 9R-dioxygenase and allene oxide synthase activities of Lasiodiplodia theobromae. 2012 Lipids pmid:22048860
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Rohr-Udilova N et al. Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. 2012 Hepatology pmid:22105228
Ebba S et al. The examination of fatty acid taste with edible strips. 2012 Physiol. Behav. pmid:22521910
Beck JJ et al. Generation of the volatile spiroketals conophthorin and chalcogran by fungal spores on polyunsaturated fatty acids common to almonds and pistachios. 2012 J. Agric. Food Chem. pmid:23153034
Ozcan MM et al. Characteristics of grape seed and oil from nine Turkish cultivars. 2012 Nat. Prod. Res. pmid:22132714
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Jung CH et al. The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells. 2012 Inflammation pmid:22124782
Jarret RL and Levy IJ Oil and fatty acid contents in seed of Citrullus lanatus Schrad. 2012 J. Agric. Food Chem. pmid:22540530
Shimomura K et al. Identification of the plant origin of propolis from Jeju Island, Korea, by observation of honeybee behavior and phytochemical analysis. 2012 Biosci. Biotechnol. Biochem. pmid:23132582
Dramane G et al. STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. 2012 J. Clin. Invest. pmid:22546859
Macaluso F et al. Effect of conjugated linoleic acid on testosterone levels in vitro and in vivo after an acute bout of resistance exercise. 2012 J Strength Cond Res pmid:22614148
Banti CN et al. Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. 2012 Metallomics pmid:22552402
Joshi S et al. Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. 2012 Org. Biomol. Chem. pmid:22986997
Little JP et al. The saturated fatty acid palmitate induces human monocytic cell toxicity toward neuronal cells: exploring a possible link between obesity-related metabolic impairments and neuroinflammation. 2012 J. Alzheimers Dis. pmid:22045487
Dubé E et al. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. 2012 Biol. Reprod. pmid:22553224
Cortie CH and Else PL Dietary docosahexaenoic Acid (22:6) incorporates into cardiolipin at the expense of linoleic Acid (18:2): analysis and potential implications. 2012 Int J Mol Sci pmid:23203135
Li J et al. A chitosan induced 9-lipoxygenase in Adelostemma gracillimum seedlings. 2012 Int J Mol Sci pmid:22312270
Krugner-Higby L et al. Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. 2012 Comp. Med. pmid:23043777
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Shah BP et al. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. 2012 Am. J. Physiol., Cell Physiol. pmid:21998136
Marincola FC et al. A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. 2012 J. Matern. Fetal. Neonatal. Med. pmid:23025771
King NP et al. Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance. 2012 BMC Microbiol. pmid:22243671
Saracoglu HT et al. Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. 2012 Nat. Prod. Res. pmid:21870933
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. 2012 Obesity (Silver Spring) pmid:22334255
Lee S et al. Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. 2012 Br. J. Nutr. pmid:21846428
Weiss LA et al. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. 2012 Am. J. Med. Genet. A pmid:22315197
de Goede J et al. Linoleic acid intake, plasma cholesterol and 10-year incidence of CHD in 20,000 middle-aged men and women in the Netherlands. 2012 Br. J. Nutr. pmid:21816117
Sun X et al. Lipid peroxidation and DNA adduct formation in lymphocytes of premenopausal women: Role of estrogen metabolites and fatty acid intake. 2012 Int. J. Cancer pmid:22322480
Matesanz N et al. Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms. 2012 J. Nutr. Biochem. pmid:21840193
Gu L et al. Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure. 2012 Food Chem. Toxicol. pmid:22940538
Sandoval-Montemayor NE et al. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. 2012 Molecules pmid:22992784
Rodrigues HG et al. Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. 2012 J. Invest. Dermatol. pmid:21881592
Nurachman Z et al. Oil from the tropical marine benthic-diatom Navicula sp. 2012 Appl. Biochem. Biotechnol. pmid:22926527
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Koch C et al. Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity. 2012 FEBS J. pmid:21920024
Osuji GO et al. Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. 2012 Appl. Biochem. Biotechnol. pmid:22918723
Kim YS et al. In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. 2012 Food Chem. Toxicol. pmid:22921350
Mukherjee S et al. NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. 2012 J. Biol. Chem. pmid:22923617
Le Maux S et al. β-Lactoglobulin as a molecular carrier of linoleate: characterization and effects on intestinal epithelial cells in vitro. 2012 J. Agric. Food Chem. pmid:22924475
Dubey V et al. Appraisal of conjugated linoleic acid production by probiotic potential of Pediococcus spp. GS4. 2012 Appl. Biochem. Biotechnol. pmid:22971829
Florence AC et al. Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. 2012 Food Chem pmid:22980792
Gursoy O et al. The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese. 2012 Int J Food Sci Nutr pmid:22166042
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Figueiredo JA et al. Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. 2012 Carbohydr. Res. pmid:22153708
Burstein S et al. N-Amino acid linoleoyl conjugates: anti-inflammatory activities. 2012 Bioorg. Med. Chem. Lett. pmid:22217875
Dundar A et al. Antioxidant properties, chemical composition and nutritional value of Terfezia boudieri (Chatin) from Turkey. 2012 Food Sci Technol Int pmid:22773542
Toomik P et al. The effect of tenderizing acids on linoleic acid oxidation during marination of pork. 2012 Meat Sci. pmid:22762994
Sajid ZI et al. Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. 2012 Molecules pmid:22466852
Shindo T et al. Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate. 2012 J Toxicol Sci pmid:22467021
Shimomoto T et al. Advanced glycation end products (AGE) induce the receptor for AGE in the colonic mucosa of azoxymethane-injected Fischer 344 rats fed with a high-linoleic acid and high-glucose diet. 2012 J. Gastroenterol. pmid:22467055
Gören AC et al. Fatty acid composition and chemotaxonomic evaluation of species of Stachys. 2012 Nat. Prod. Res. pmid:21859257
Zein CO et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. 2012 Hepatology pmid:22505276
Takahashi T et al. Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability. 2012 Reprod. Domest. Anim. pmid:21635578
Wadekar SD et al. Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. 2012 Prep. Biochem. Biotechnol. pmid:22509850
Ling PR et al. Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. 2012 Metab. Clin. Exp. pmid:22512821
Manosroi A et al. Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction. 2012 Eur J Pharm Biopharm pmid:22490981
Liu X et al. Method for screening of bacterial strains biosynthesizing specific conjugated linoleic acid isomers. 2012 J. Agric. Food Chem. pmid:22946615
Eserian JK et al. Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. 2012 Nutr Neurosci pmid:22390908
Fei J et al. ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. 2012 Atherosclerosis pmid:22464285
Steffen BT et al. Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. 2012 Int J Obes (Lond) pmid:21829163
Jarvis MF Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. 2012 Pain pmid:22681878
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Ren HT et al. Influence of dietary fatty acids on muscle fatty acid composition and expression levels of Δ6 desaturase-like and Elovl5-like elongase in common carp (Cyprinus carpio var. Jian). 2012 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:22677415
Angell RJ et al. Fish oil supplementation maintains adequate plasma arachidonate in cats, but similar amounts of vegetable oils lead to dietary arachidonate deficiency from nutrient dilution. 2012 Nutr Res pmid:22652378
Burrows T et al. A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids. 2012 Eur J Clin Nutr pmid:22378224
Vanek VW et al. A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. 2012 Nutr Clin Pract pmid:22378798
Shin D et al. Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. 2012 Poult. Sci. pmid:22399741
Billault I et al. Probing substrate-product relationships by natural abundance deuterium 2D NMR spectroscopy in liquid-crystalline solvents: epoxidation of linoleate to vernoleate by two different plant enzymes. 2012 Anal Bioanal Chem pmid:22349323
Khan R et al. Variation in oil content and fatty acid composition of the seed oil of Acacia species collected from the northwest zone of India. 2012 J. Sci. Food Agric. pmid:22351513
Chen MH and Nelson EB Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. 2012 Phytopathology pmid:22352306
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
He M et al. Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. 2012 J. Dairy Sci. pmid:22365227
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Li KL et al. Characterization of cumulus expansion-inhibiting factor (CEIF) in goat follicles. 2012 Biol. Reprod. pmid:22402961
Dall'Asta C et al. Role of maize hybrids and their chemical composition in Fusarium infection and fumonisin production. 2012 J. Agric. Food Chem. pmid:22409349
Mulligan CM et al. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. 2012 Cardiovasc. Res. pmid:22411972
Gull J et al. Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. 2012 Molecules pmid:22418924
Santos FS et al. Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. 2012 J Pediatr Adolesc Gynecol pmid:22840939
McPherson PA et al. A curvilinear approach to the kinetic analysis of linoleate peroxidation in aqueous liposomes by 2,2'azobis(2-amidoinopropane) dihydrochloride. 2012 Chem. Phys. Lipids pmid:22841574
Sultana B et al. Investigation on the antioxidant activity of leaves, peels, stems bark, and kernel of mango (Mangifera indica L.). 2012 J. Food Sci. pmid:22860576