Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Lymphopenia D008231 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Melanosis D008548 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Otitis Externa D010032 8 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Bellini MJ et al. Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:14580370
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Vancassel S et al. Plasma fatty acid levels in autistic children. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487301
Pickens CA et al. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25559239
Tribole E What happened to do no harm? The issue of dietary omega-6 fatty acids. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147337
Ramsden CE et al. Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147338
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Kilian M et al. Influence of conjugated and conventional linoleic acid on tumor growth and lipid peroxidation in pancreatic adenocarcinoma in hamster. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878453
Shapiro H et al. Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27067460
Hover CG and Kulkarni AP A simple and efficient method for hemoglobin removal from mammalian tissue cytosol by zinc sulfate and its application to the study of lipoxygenase. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780874
Charnock JS Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780878
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Glew RH et al. Fatty acid composition of the milk lipids of Nepalese women: correlation between fatty acid composition of serum phospholipids and melting point. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728165
Kritchevsky D Trans fatty acids and cardiovascular risk. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430386
Renaud SC Dietary management of cardiovascular diseases. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430390