Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan H et al. | A network based covariance test for detecting multivariate eQTL in saccharomyces cerevisiae. | 2016 | BMC Syst Biol | pmid:26818242 |
| Rosenblat M et al. | Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes. | 2016 | Lipids | pmid:27344666 |
| Abreu P et al. | Contractile function recovery in severely injured gastrocnemius muscle of rats treated with either oleic or linoleic acid. | 2016 | Exp. Physiol. | pmid:27579497 |
| Raimondi S et al. | Conjugated Linoleic Acid Production by Bifidobacteria: Screening, Kinetic, and Composition. | 2016 | Biomed Res Int | pmid:27429985 |
| Yousr M and Howell N | Antioxidant and ACE Inhibitory Bioactive Peptides Purified from Egg Yolk Proteins. | 2015 | Int J Mol Sci | pmid:26690134 |
| Liu HC et al. | Transcriptome changes in Polygonum multiflorum Thunb. roots induced by methyl jasmonate. | 2015 | J Zhejiang Univ Sci B | pmid:26642186 |
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| Qian Z et al. | Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice. | 2015 | Sci Rep | pmid:26615818 |
| Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
| Guyenet SJ and Carlson SE | Increase in adipose tissue linoleic acid of US adults in the last half century. | 2015 | Adv Nutr | pmid:26567191 |
| Phan CW et al. | Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism. | 2015 | PLoS ONE | pmid:26565787 |
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| Ellero-Simatos S et al. | Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study. | 2015 | J Am Heart Assoc | pmid:26504148 |
| Farvid MS et al. | Response to Letters Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195494 |
| Lucas M | Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study". | 2015 | Circulation | pmid:26195492 |
| Hoenselaar R | Letter by Hoenselaar Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195491 |
| Yuan T et al. | Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. | 2015 | Int J Clin Exp Pathol | pmid:26191198 |
| Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
| Salehi R et al. | A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum. | 2015 | Reprod. Biol. Endocrinol. | pmid:26138920 |
| Grevengoed TJ et al. | Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function. | 2015 | J. Lipid Res. | pmid:26136511 |
| Hasiewicz-Derkacz K et al. | Natural phenolics greatly increase flax (Linum usitatissimum) oil stability. | 2015 | BMC Biotechnol. | pmid:26123633 |
| Rosero DS et al. | Impact of dietary lipids on sow milk composition and balance of essential fatty acids during lactation in prolific sows. | 2015 | J. Anim. Sci. | pmid:26115280 |
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| Alsaidan M et al. | Cells to Surgery Quiz: July 2015. | 2015 | J. Invest. Dermatol. | pmid:26066894 |
| Schumann T et al. | Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. | 2015 | Oncotarget | pmid:25968567 |
| Hirata A et al. | A novel unsaturated fatty acid hydratase toward C16 to C22 fatty acids from Lactobacillus acidophilus. | 2015 | J. Lipid Res. | pmid:25966711 |
| Turci F et al. | Free-radical chemistry as a means to evaluate lunar dust health hazard in view of future missions to the moon. | 2015 | Astrobiology | pmid:25946080 |
| Dahlhoff M et al. | EGFR/ERBB receptors differentially modulate sebaceous lipogenesis. | 2015 | FEBS Lett. | pmid:25889637 |
| Gouveia-Figueira S et al. | Serum levels of oxylipins in achilles tendinopathy: an exploratory study. | 2015 | PLoS ONE | pmid:25875933 |
| Mansour AB et al. | Effect of agricultural sites on differentiation between Chemlali and Neb Jmel olive oils. | 2015 | J Oleo Sci | pmid:25833451 |
| Guo Q et al. | Impact of additives on thermally-induced trans isomers in 9c,12c linoleic acid triacylglycerol. | 2015 | Food Chem | pmid:25529684 |
| Nardi F et al. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. | 2015 | J. Biol. Chem. | pmid:25653282 |
| Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
| Hsieh JC et al. | High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:25633498 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
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| Jones PJ et al. | High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. | 2015 | Atherosclerosis | pmid:25528432 |
| Chan BC et al. | Combating against methicillin-resistant Staphylococcus aureus - two fatty acids from Purslane (Portulaca oleracea L.) exhibit synergistic effects with erythromycin. | 2015 | J. Pharm. Pharmacol. | pmid:25212982 |
| Miyamoto J et al. | A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway. | 2015 | J. Biol. Chem. | pmid:25505251 |
| Liu H et al. | Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. | 2015 | Am. J. Pathol. | pmid:25447051 |
| Reinders I et al. | Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adults. | 2015 | J. Nutr. | pmid:25355842 |
| Baylin A et al. | Serum Trans Fatty Acids Are Not Associated with Weight Gain or Linear Growth in School-Age Children. | 2015 | J. Nutr. | pmid:26180252 |
| Pickens CA et al. | Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25559239 |
| Perumalsamy H et al. | Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. | 2015 | Parasit Vectors | pmid:25928224 |
| Kim SY et al. | Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway. | 2015 | Int. J. Mol. Med. | pmid:25672876 |
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| Zeb A and Ullah S | Sea buckthorn seed oil protects against the oxidative stress produced by thermally oxidized lipids. | 2015 | Food Chem | pmid:25976784 |
| Beam J et al. | Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. | 2015 | J. Biol. Chem. | pmid:26240151 |
| Okazaki H et al. | Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform. | 2015 | J Toxicol Sci | pmid:25786526 |
| Nakahashi H et al. | Evaluation of the Key Odorants in Volatile Oils from Tubers of Apios americana Medikus. | 2015 | J Oleo Sci | pmid:26521814 |