Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
Biagi PL et al. | Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. | 1993 | Acta Paediatr. | pmid:8241678 |
ARFFMANN E | HEATED FATS AND ALLIED COMPOUNDS AS CARCINOGENS; STUDIED BY THE NEWT TEST. | 1964 | Acta Pathol Microbiol Scand | pmid:14162795 |
Jensen GE and Clausen J | Glutathione peroxidase activity, associated enzymes and substrates in blood cells from patients with multiple sclerosis--effects of antioxidant supplementation. | 1986 | Acta Pharmacol Toxicol (Copenh) | pmid:3776606 |
Yang XF et al. | In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin. | 2003 | Acta Pharmacol. Sin. | pmid:12676068 |
Xu QY et al. | Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats. | 2014 | Acta Pharmacol. Sin. | pmid:25220639 |
Cui YF et al. | Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:12617780 |
HAUGE JG and NICOLAYSEN R | The serum cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaemic rats. | 1959 | Acta Physiol. Scand. | pmid:13626601 |
BLOMSTRAND R | The intestinal absorption of linoleic-1-14C acid. | 1954 | Acta Physiol. Scand. | pmid:13228101 |
Alinezhad H et al. | Biochemical activities of acetone extracts of Hyssopus angustifolius. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876603 |
Moghaddam AH et al. | Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876611 |
Ozen T | Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. | 2009 Mar-Apr | Acta Pol Pharm | pmid:19719054 |
Olszewska MA | Variation in the phenolic content and in vitro antioxidant activity of Sorbus aucuparia leaf extracts during vegetation. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125960 |
Olszewska MA | In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125961 |
Kezutyte T et al. | Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125963 |
Baek JH et al. | Lithium tremor revisited: pathophysiology and treatment. | 2014 | Acta Psychiatr Scand | pmid:23834617 |
Leichsenring M et al. | Scaly skin alterations and plasma fatty acids in Congolese children. | 1993 | Acta Trop. | pmid:7902652 |
Ermidou-Pollet S et al. | Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. | 2005 | Acta. Biol. Hung. | pmid:16196200 |
Arawwawala M et al. | In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. | 2011 | Acta. Biol. Hung. | pmid:21840826 |
Guyenet SJ and Carlson SE | Increase in adipose tissue linoleic acid of US adults in the last half century. | 2015 | Adv Nutr | pmid:26567191 |
Whelan J and Fritsche K | Linoleic acid. | 2013 | Adv Nutr | pmid:23674797 |
Birnbaum L | Addition of conjugated linoleic acid to a herbal anticellulite pill. | 2001 Sep-Oct | Adv Ther | pmid:11783459 |
Tanaka R et al. | Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. | 2012 | Adv. Exp. Med. Biol. | pmid:22259110 |
Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
Tsukamoto S et al. | Effects of bezafibrate on ethanol oxidation in rats. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8986210 |
Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
Szebeni J et al. | Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. | 1986 | Alcohol. Clin. Exp. Res. | pmid:3101533 |
Nielsen AA et al. | Omega-3 fatty acids inhibit an increase of proinflammatory cytokines in patients with active Crohn's disease compared with omega-6 fatty acids. | 2005 | Aliment. Pharmacol. Ther. | pmid:16305726 |
Uden S et al. | Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. | 1992 | Aliment. Pharmacol. Ther. | pmid:1600043 |
Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
Poole E and McQueen CE | Conjugated linoleic acid. | 2006 | Am J Health Syst Pharm | pmid:17057041 |
Block RC et al. | Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? | 2008 | Am. Heart J. | pmid:19033007 |
Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
McDaniel HG et al. | Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. | 1981 | Am. Heart J. | pmid:6787909 |
Magsino CH et al. | Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. | 2000 | Am. J. Cardiol. | pmid:10946040 |
Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
Kim JB et al. | Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | 2013 | Am. J. Cardiol. | pmid:24050409 |
Wu MJ et al. | Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). | 2004 | Am. J. Chin. Med. | pmid:15633804 |
Cho EJ et al. | The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. | 2003 | Am. J. Chin. Med. | pmid:14992543 |
CAMPBELL AM et al. | SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. | 1965 | Am. J. Clin. Nutr. | pmid:14332349 |
Hrboticky N et al. | Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. | 1991 | Am. J. Clin. Nutr. | pmid:1989416 |
Freese R et al. | High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. | 2002 | Am. J. Clin. Nutr. | pmid:12399265 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |