Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhang JS et al. | [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway]. | 2007 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18399127 |
Sun CH et al. | [Effects of conjugated linoleic acid on expression of GLUT4 protein in skeletal muscle of insulin resistant rat]. | 2007 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:17484206 |
Ye P et al. | [An exploratory study on mechanism of PPARalpha activators-induced plasminogen activator inhibitor-1 expression in HepG-2 cells]. | 2004 | Zhonghua Nei Ke Za Zhi | pmid:15631825 |
Li KC et al. | [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. | 2013 | Zhonghua Gan Zang Bing Za Zhi | pmid:24025140 |
Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
Matthaus B et al. | Some rape/canola seed oils: fatty acid composition and tocopherols. | 2016 | Z. Naturforsch., C, J. Biosci. | pmid:27023318 |
He J et al. | Correlation of polyunsaturated fatty acids with the cold adaptation of Rhodotorula glutinis. | 2015 | Yeast | pmid:26284451 |
Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
Kainou K et al. | Isolation of Delta12 and omega3-fatty acid desaturase genes from the yeast Kluyveromyces lactis and their heterologous expression to produce linoleic and alpha-linolenic acids in Saccharomyces cerevisiae. | 2006 | Yeast | pmid:16823888 |
Nakagawa Y | [Metabolism and biological function of cardiolipin]. | 2013 | Yakugaku Zasshi | pmid:23649397 |
Fujii M | Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice. | 2017 | Yakugaku Zasshi | pmid:28049895 |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Cardoso CR et al. | Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. | 2004 Mar-Apr | Wound Repair Regen | pmid:15086775 |
Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
Okuyama H et al. | New Cholesterol Guidelines for Longevity (2010). | 2011 | World Rev Nutr Diet | pmid:21865826 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Okuyama H et al. | Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. | 2007 | World Rev Nutr Diet | pmid:17167282 |
Okuyama H et al. | Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? | 2007 | World Rev Nutr Diet | pmid:17167283 |
Okuyama H et al. | Mechanisms by which dietary fats affect coronary heart disease mortality. | 2007 | World Rev Nutr Diet | pmid:17167284 |
Okuyama H et al. | Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. | 2007 | World Rev Nutr Diet | pmid:17167285 |
Zheng HF et al. | Effects of unsaturated fatty acids on calcium-activated potassium current in gastric myocytes of guinea pigs. | 2005 | World J. Gastroenterol. | pmid:15655819 |
Chen BQ et al. | Effects of c9,t11-conjugated linoleic acid on adhesion of human gastric carcinoma cell line SGC-7901. | 2004 | World J. Gastroenterol. | pmid:15133841 |
Chen BQ et al. | Inhibition of conjugated linoleic acid on mouse forestomach neoplasia induced by benzo (a) pyrene and chemopreventive mechanisms. | 2003 | World J. Gastroenterol. | pmid:12508349 |
Moon C et al. | Modeling sulfate removal by inhibited mesophilic mixed anaerobic communities using a statistical approach. | 2013 | Water Res. | pmid:23466036 |
Sasaki T et al. | Peritoneal metastasis inhibition by linoleic acid with activation of PPARgamma in human gastrointestinal cancer cells. | 2006 | Virchows Arch. | pmid:16362414 |
Plantinga EA et al. | Relationship between the amount of linoleic acid in the diet and that in the adipose tissue of adult cats living freely in households. | 2003 | Vet. Res. Commun. | pmid:14672449 |
Mena J et al. | Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. | 2013 | Vet. Immunol. Immunopathol. | pmid:23267746 |
Thanasak J et al. | Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. | 2005 | Vet. Immunol. Immunopathol. | pmid:15734550 |
van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
Rashed MM et al. | Effect of ultrasonic treatment on total phenolic extraction from Lavandula pubescens and its application in palm olein oil industry. | 2016 | Ultrason Sonochem | pmid:26584982 |
Mikkola JP et al. | Utilisation of on-line acoustic irradiation as a means to counter-effect catalyst deactivation in heterogeneous catalysis. | 2004 | Ultrason Sonochem | pmid:15081987 |
Nguyen LQ et al. | Intake of essential fatty acids by growing-finishing pigs kept on smallholdings in central Vietnam. | 2005 | Trop Anim Health Prod | pmid:15729898 |
Blée E | Impact of phyto-oxylipins in plant defense. | 2002 | Trends Plant Sci. | pmid:12119169 |
Hansen HS | Linoleic acid as a precursor for acylation of transducin, a retinol G protein? | 1993 | Trends Biochem. Sci. | pmid:8328015 |
Perez RV et al. | Dietary immunoregulation of transfusion-induced immunosuppression. | 1988 | Transplantation | pmid:3258077 |
Tchervenkov JI et al. | The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. | 1989 | Transplantation | pmid:2643225 |
Perez RV et al. | Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid. | 1989 | Transplantation | pmid:2660353 |
Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
Sidransky H and Verney E | Toxic effect of valproic acid on tryptophan binding to rat hepatic nuclei. | 1996 | Toxicology | pmid:8619251 |
Heiskanen K et al. | Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes. | 1995 | Toxicology | pmid:8560489 |
Ramirez DC and Gimenez MS | Lipid modification in mouse peritoneal macrophages after chronic cadmium exposure. | 2002 | Toxicology | pmid:11844611 |
Leitch AC et al. | B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals. | 2017 | Toxicology | pmid:28552552 |
Gülçin I | Antioxidant activity of caffeic acid (3,4-dihydroxycinnamic acid). | 2006 | Toxicology | pmid:16243424 |
Montaño M et al. | New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. | 2012 | Toxicol. Sci. | pmid:22859314 |
Vanden Heuvel JP et al. | Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. | 2006 | Toxicol. Sci. | pmid:16731579 |
Wang X et al. | From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. | 2018 | Toxicol. Sci. | pmid:29045746 |
Matsusue K et al. | A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. | 1997 | Toxicol. Lett. | pmid:9175845 |
Alghazeer R et al. | Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). | 2008 | Toxicol. Lett. | pmid:18625293 |
Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
Mitchell LA et al. | Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. | 2002 | Toxicol. Lett. | pmid:11814707 |
Moran JH et al. | Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. | 2000 | Toxicol. Appl. Pharmacol. | pmid:11042099 |
Ha J et al. | Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. | 2002 | Toxicol. Appl. Pharmacol. | pmid:12127265 |
Moran JH et al. | Cytotoxicity of linoleic acid diols to renal proximal tubular cells. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9299596 |
Moran JH et al. | Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11714247 |
Yu WK and Wells PG | Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878664 |
Wey HE et al. | Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. | 1993 | Toxicol. Appl. Pharmacol. | pmid:8511784 |
Moran JH et al. | Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11298501 |
Slim R et al. | The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11243918 |
Oh JM et al. | Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. | 2012 | Toxicol In Vitro | pmid:22683933 |
Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Sakayori N et al. | Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice. | 2016 | Tohoku J. Exp. Med. | pmid:27558477 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
Segal LN et al. | Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung. | 2017 | Thorax | pmid:27486204 |
Laowtammathron C et al. | Factors affecting cryosurvival of nuclear-transferred bovine and swamp buffalo blastocysts: effects of hatching stage, linoleic acid-albumin in IVC medium and Ficoll supplementation to vitrification solution. | 2005 | Theriogenology | pmid:16125561 |
Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
Carro M et al. | Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. | 2013 | Theriogenology | pmid:23273433 |
Tominaga K et al. | Effect of lipid polarization by centrifugation at different developmental stages on post-thaw survival of bovine in vitro produced 16-cell embryos. | 2000 | Theriogenology | pmid:10883852 |
Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
Pérez-Pé R et al. | Semen plasma proteins prevent cold-shock membrane damage to ram spermatozoa. | 2001 | Theriogenology | pmid:11516122 |
Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
Hochi S et al. | Effect of linoleic acid-albumin in the culture medium on freezing sensitivity of in vitro-produced bovine morulae. | 1999 | Theriogenology | pmid:10734383 |
Gigli I et al. | Effects of oxygen tension and supplements to the culture medium on activation and development of bovine follicles in vitro. | 2006 | Theriogenology | pmid:16442155 |
Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |
Klein J et al. | Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. | 1999 | Ther Drug Monit | pmid:10604826 |
Liu Q et al. | Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). | 2013 | Theor. Appl. Genet. | pmid:23695179 |
Rezzonico E et al. | Level of accumulation of epoxy fatty acid in Arabidopsis thaliana expressing a linoleic acid delta12-epoxygenase is influenced by the availability of the substrate linoleic acid. | 2004 | Theor. Appl. Genet. | pmid:15221145 |
Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Viscardi RM and Max SR | Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells. | 1993 | Steroids | pmid:8212085 |
Cigliano L et al. | Estradiol esterification in the human preovulatory follicle. | 2001 | Steroids | pmid:11711117 |
Blask DE | Melatonin, sleep disturbance and cancer risk. | 2009 | Sleep Med Rev | pmid:19095474 |
Amakura Y et al. | Characteristic long-chain fatty acid of Pleurocybella porrigens. | 2006 | Shokuhin Eiseigaku Zasshi | pmid:16984039 |
Wang L et al. | [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. | 2010 | Sheng Li Xue Bao | pmid:21170499 |
Buchanan MR and Brister SJ | Altering vessel wall fatty acid metabolism: a new strategy for antithrombotic treatment. | 1993 | Semin. Thromb. Hemost. | pmid:8356461 |
Phan CW et al. | Intrastrain comparison of the chemical composition and antioxidant activity of an edible mushroom, Pleurotus giganteus, and its potent neuritogenic properties. | 2014 | ScientificWorldJournal | pmid:25121118 |
de Sousa Ferreira Soares G et al. | Spectroscopic and thermooxidative analysis of organic okra oil and seeds from Abelmoschus esculentus. | 2012 | ScientificWorldJournal | pmid:22645459 |
Broun P et al. | Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. | 1998 | Science | pmid:9812895 |
Mead JF | The Irradiation-Induced Autoxidation of Linoleic Acid. | 1952 | Science | pmid:17749056 |
Stocker R et al. | Bilirubin is an antioxidant of possible physiological importance. | 1987 | Science | pmid:3029864 |
Lee M et al. | Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. | 1998 | Science | pmid:9572738 |
Chen Q et al. | Generation of fad2 transgenic mice that produce omega-6 fatty acids. | 2009 | Sci. China, C, Life Sci. | pmid:19937203 |
Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |