Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Applegate TJ and Sell JL | Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. | 1996 | Poult. Sci. | pmid:8966177 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Shin D et al. | Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. | 2011 | Poult. Sci. | pmid:21597077 |
Sell JL et al. | Metabolizable energy value of conjugated linoleic acid for broiler chicks and laying hens. | 2001 | Poult. Sci. | pmid:11233010 |
Du M et al. | Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. | 2001 | Poult. Sci. | pmid:11233015 |
Sijben JW et al. | Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. | 2000 | Poult. Sci. | pmid:10947178 |
Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
Keshavarz K | Further investigations on the effect of dietary manipulations of nutrients on early egg weight. | 1995 | Poult. Sci. | pmid:7899214 |
Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Badinga L et al. | Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. | 2003 | Poult. Sci. | pmid:12580252 |
Engberg RM et al. | Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. | 1996 | Poult. Sci. | pmid:8829233 |
Latour MA et al. | Effects of conjugated linoleic acid. 1. Fatty acid modification of yolks and neonatal fatty acid metabolism. | 2000 | Poult. Sci. | pmid:10875761 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Latour MA et al. | Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids. | 2000 | Poult. Sci. | pmid:10875762 |
Lee BD et al. | Nutritive and economic values of high oil corn in layer diet. | 2001 | Poult. Sci. | pmid:11732667 |
Puthpongsiriporn U and Scheideler SE | Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. | 2005 | Poult. Sci. | pmid:15971520 |
Ferrini G et al. | Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. | 2008 | Poult. Sci. | pmid:18281580 |
Ain Baziz H et al. | Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. | 1996 | Poult. Sci. | pmid:8786940 |
Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
Potter LM and McCarthy JP | Varying fat and protein in diets of growing large white turkeys. | 1985 | Poult. Sci. | pmid:4070128 |
Wang YW et al. | Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. | 2004 | Poult. Sci. | pmid:15615018 |
Safaa HM et al. | Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. | 2008 | Poult. Sci. | pmid:18648054 |
Vilchez C et al. | Research note: eggshell quality in Japanese quail fed different fatty acids. | 1992 | Poult. Sci. | pmid:1409241 |
Du M and Ahn DU | Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. | 2002 | Poult. Sci. | pmid:11902422 |
Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. | 1991 | Poult. Sci. | pmid:1784570 |
Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
Du M et al. | Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. | 2002 | Poult. Sci. | pmid:12269620 |
Chamruspollert M and Sell JL | Transfer of dietary conjugated linoleic acid to egg yolks of chickens. | 1999 | Poult. Sci. | pmid:10472840 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Ahn DU et al. | Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. | 1999 | Poult. Sci. | pmid:10438141 |
Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 2. Maternal diets and stage of incubation on the lipid metabolism of quail embryos. | 1992 | Poult. Sci. | pmid:1614943 |
Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
Kim JH et al. | Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. | 2007 | Poult. Sci. | pmid:17495090 |
Shin D et al. | Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. | 2012 | Poult. Sci. | pmid:22399741 |
Wadekar SD et al. | Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. | 2012 | Prep. Biochem. Biotechnol. | pmid:22509850 |
Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
Utermohlen V and Tucker MA | Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. | 1986 | Proc Nutr Soc | pmid:3797410 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
Blaul B and Ruther J | How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. | 2011 | Proc. Biol. Sci. | pmid:21429922 |
Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Baker PR et al. | Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273286 |
Whittle EJ et al. | Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18796606 |
Jiang Q et al. | gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15596715 |
Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
Saeki K et al. | Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15067141 |
Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
Wright JR et al. | Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3045812 |
Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
Hill EG et al. | Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6951178 |
Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |
Keler T et al. | Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1594582 |
Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |
Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
Pasqualini ME et al. | Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538085 |
Gonzalez B et al. | Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883061 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Cunnane SC and Guesnet P | Linoleic acid recommendations--A house of cards. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21963263 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20673710 |
Okui T et al. | Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21723718 |
Shapiro H et al. | Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. | 2016 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:27067460 |
Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
Kuipers RS et al. | Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17383169 |