Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Genetic Diseases, X-Linked D040181 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Lymphopenia D008231 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Melanosis D008548 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Otitis Externa D010032 8 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Alopecia D000505 14 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Tuberculosis D014376 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Kidney Diseases D007674 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Applegate TJ and Sell JL Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. 1996 Poult. Sci. pmid:8966177
Du M et al. Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. 2000 Poult. Sci. pmid:11194037
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Sell JL et al. Metabolizable energy value of conjugated linoleic acid for broiler chicks and laying hens. 2001 Poult. Sci. pmid:11233010
Du M et al. Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. 2001 Poult. Sci. pmid:11233015
Sijben JW et al. Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. 2000 Poult. Sci. pmid:10947178
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Keshavarz K Further investigations on the effect of dietary manipulations of nutrients on early egg weight. 1995 Poult. Sci. pmid:7899214
Sirri F et al. Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. 2003 Poult. Sci. pmid:12943310
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Badinga L et al. Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. 2003 Poult. Sci. pmid:12580252
Engberg RM et al. Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. 1996 Poult. Sci. pmid:8829233
Latour MA et al. Effects of conjugated linoleic acid. 1. Fatty acid modification of yolks and neonatal fatty acid metabolism. 2000 Poult. Sci. pmid:10875761
Ding ST and Lilburn MS Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. 1997 Poult. Sci. pmid:9181615
Latour MA et al. Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids. 2000 Poult. Sci. pmid:10875762
Lee BD et al. Nutritive and economic values of high oil corn in layer diet. 2001 Poult. Sci. pmid:11732667
Puthpongsiriporn U and Scheideler SE Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. 2005 Poult. Sci. pmid:15971520
Ferrini G et al. Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. 2008 Poult. Sci. pmid:18281580
Ain Baziz H et al. Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. 1996 Poult. Sci. pmid:8786940
Sijben JW et al. Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. 2001 Poult. Sci. pmid:11469650
Potter LM and McCarthy JP Varying fat and protein in diets of growing large white turkeys. 1985 Poult. Sci. pmid:4070128
Wang YW et al. Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. 2004 Poult. Sci. pmid:15615018
Safaa HM et al. Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. 2008 Poult. Sci. pmid:18648054
Vilchez C et al. Research note: eggshell quality in Japanese quail fed different fatty acids. 1992 Poult. Sci. pmid:1409241
Du M and Ahn DU Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. 2002 Poult. Sci. pmid:11902422
Grobas S et al. Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. 1999 Poult. Sci. pmid:10560827
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. 1991 Poult. Sci. pmid:1784570
Du M et al. Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. 1999 Poult. Sci. pmid:10560841
Du M et al. Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. 2002 Poult. Sci. pmid:12269620
Chamruspollert M and Sell JL Transfer of dietary conjugated linoleic acid to egg yolks of chickens. 1999 Poult. Sci. pmid:10472840
Cherian G et al. Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. 2002 Poult. Sci. pmid:12412926
Ahn DU et al. Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. 1999 Poult. Sci. pmid:10438141
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 2. Maternal diets and stage of incubation on the lipid metabolism of quail embryos. 1992 Poult. Sci. pmid:1614943
Aletor VA et al. The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. 2003 Poult. Sci. pmid:12762403
Watkins BA and Kratzer FH Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. 1987 Poult. Sci. pmid:3452223
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090
Shin D et al. Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. 2012 Poult. Sci. pmid:22399741
Wadekar SD et al. Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. 2012 Prep. Biochem. Biotechnol. pmid:22509850
Dupont J Essential fatty acids and prostaglandins. 1987 Prev Med pmid:3628199
Cohen LA Fat and endocrine-responsive cancer in animals. 1987 Prev Med pmid:3476922
Utermohlen V and Tucker MA Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. 1986 Proc Nutr Soc pmid:3797410
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Blaul B and Ruther J How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. 2011 Proc. Biol. Sci. pmid:21429922
Wieland E et al. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8327462
Levay-Young BK et al. Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3317407
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Baker PR et al. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15273286
Whittle EJ et al. Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18796606
Jiang Q et al. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15596715
Asaoka Y et al. Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8099446
Saeki K et al. Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15067141
Kliewer SA et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8041794
Chu S et al. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624373
Wright JR et al. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3045812
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Stocker R et al. Antioxidant activity of albumin-bound bilirubin. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3475708
Hill EG et al. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6951178
Lange LG Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6955782
Keler T et al. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1594582
Watkins BA et al. Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. 1996 Proc. Soc. Exp. Biol. Med. pmid:8650253
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Cunnane SC Problems with essential fatty acids: time for a new paradigm? 2003 Prog. Lipid Res. pmid:14559071
Cunnane SC Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. 1982 Prog. Lipid Res. pmid:7051042
Dwyer LA and Blomquist GJ Biosynthesis of linoleic acid in the American cockroach. 1981 Prog. Lipid Res. pmid:7342085
Launay M et al. Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. 1981 Prog. Lipid Res. pmid:7342098
Houtsmuller AJ et al. Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. 1981 Prog. Lipid Res. pmid:7342100
Kitada S et al. Characterization of a lipid mobilizing factor from tumors. 1981 Prog. Lipid Res. pmid:7342133
Houtsmuller UM and van der Beek A Effects of topical application of fatty acids. 1981 Prog. Lipid Res. pmid:6804961
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Spector AA et al. Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. 1981 Prog. Lipid Res. pmid:7043481
Agradi E et al. Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. 1981 Prog. Lipid Res. pmid:7043483
Mercuri O and De Tomás ME Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. 1981 Prog. Lipid Res. pmid:6804968
Sakuma S et al. Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. 1993 Prostaglandins pmid:8210445
Lewis MG et al. Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. 1981 Prostaglandins pmid:6799988
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Needleman SW et al. Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. 1982 Prostaglandins pmid:6819602
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Beneytout JL et al. Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. 1986 Prostaglandins pmid:3086939
Engels F et al. Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. 1996 Prostaglandins pmid:8880897
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Bronstein JC and Bull AW The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. 1993 Prostaglandins pmid:8278616
Andersen BR et al. The effects of arachidonic and other fatty acids on canine neutrophil metabolism. 1981 Prostaglandins pmid:6795686
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Singer P et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. 1984 Prostaglandins pmid:6328578
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Gonzalez B et al. Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10883061
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Okui T et al. Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21723718
Shapiro H et al. Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27067460
Punchard NA et al. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765976
Mohan IK and Das UN Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765977
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169