Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lucas M | Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study". | 2015 | Circulation | pmid:26195492 |
Hoenselaar R | Letter by Hoenselaar Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195491 |
Yuan T et al. | Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. | 2015 | Int J Clin Exp Pathol | pmid:26191198 |
Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
Vlachogianni IC et al. | In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives. | 2015 | Food Chem | pmid:25660873 |
Nardi F et al. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. | 2015 | J. Biol. Chem. | pmid:25653282 |
Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
Beam J et al. | Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. | 2015 | J. Biol. Chem. | pmid:26240151 |
Okazaki H et al. | Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform. | 2015 | J Toxicol Sci | pmid:25786526 |
Naughton SS et al. | Australia's nutrition transition 1961-2009: a focus on fats. | 2015 | Br. J. Nutr. | pmid:26123446 |