Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
Terpstra AH | Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. | 2001 | J. Nutr. | pmid:11435531 |
Banni S et al. | Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. | 2001 | J. Lipid Res. | pmid:11441132 |
Heydeck D et al. | Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions. | 2001 | J. Lipid Res. | pmid:11441135 |
Aljada A et al. | Nuclear factor-kappaB suppressive and inhibitor-kappaB stimulatory effects of troglitazone in obese patients with type 2 diabetes: evidence of an antiinflammatory action? | 2001 | J. Clin. Endocrinol. Metab. | pmid:11443197 |
Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
Whitehouse AS and Tisdale MJ | Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11453634 |
Yu L | Free radical scavenging properties of conjugated linoleic acids. | 2001 | J. Agric. Food Chem. | pmid:11453790 |
Thiel-Cooper RL et al. | Conjugated linoleic acid changes swine performance and carcass composition. | 2001 | J. Anim. Sci. | pmid:11465369 |
Ramaswamy N et al. | Short communication: Consumer evaluation of milk high in conjugated linoleic acid. | 2001 | J. Dairy Sci. | pmid:11467809 |
Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. | 2001 | Am. J. Clin. Nutr. | pmid:11470727 |
Kachhap SK et al. | Effect of omega-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line. | 2001 | Cancer Biother. Radiopharm. | pmid:11471489 |
Malkowski MG et al. | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. | 2001 | J. Biol. Chem. | pmid:11477109 |
Spector AA | Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478370 |
Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2001 | J. Nutr. | pmid:11481404 |
Phoon MC et al. | Linoleic and linolelaidic acids differentially influence proliferation and apoptosis of MOLT-4 leukaemia cells. | 2001 | Cell Biol. Int. | pmid:11482901 |
Seddon JM et al. | Dietary fat and risk for advanced age-related macular degeneration. | 2001 | Arch. Ophthalmol. | pmid:11483088 |
Takeda M et al. | Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test. | 2001 | Life Sci. | pmid:11487096 |
Vancassel S et al. | Plasma fatty acid levels in autistic children. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487301 |
Harris MA et al. | Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487304 |
Sewram V et al. | Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. | 2001 | Planta Med. | pmid:11488461 |
Chen ZY et al. | Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats. | 2001 | Br. J. Nutr. | pmid:11502239 |
Chang W et al. | Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells. | 2001 | Mol. Cell. Biochem. | pmid:11506175 |
Févrie P et al. | Separation of glyceride positional isomers by silver ion chromatography. | 2001 | J Chromatogr A | pmid:11510559 |
Prescha A et al. | Increase in lipid content in potato tubers modified by 14-3-3 gene overexpression. | 2001 | J. Agric. Food Chem. | pmid:11513640 |
Lin Y et al. | Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. | 2001 | Biochim. Biophys. Acta | pmid:11514234 |
Pérez-Pé R et al. | Semen plasma proteins prevent cold-shock membrane damage to ram spermatozoa. | 2001 | Theriogenology | pmid:11516122 |
Ramsay TG et al. | Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. | 2001 | J. Anim. Sci. | pmid:11518224 |
Wiegand BR et al. | Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in stress-genotype pigs. | 2001 | J. Anim. Sci. | pmid:11518228 |
Kucuk O et al. | Effect of forage:concentrate ratio on ruminal digestion and duodenal flow of fatty acids in ewes. | 2001 | J. Anim. Sci. | pmid:11518234 |
Abu-Ghazaleh AA et al. | Conjugated linoleic acid and other beneficial fatty acids in milk fat from cows fed soybean meal, fish meal, or both. | 2001 | J. Dairy Sci. | pmid:11518309 |
Cubillos MA et al. | Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) dihydrochloride. | 2001 | Chem. Phys. Lipids | pmid:11518571 |
Olsson U et al. | Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance. | 2001 | Diabetes | pmid:11522680 |
Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
Brown JM et al. | Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. | 2001 | J. Nutr. | pmid:11533273 |
Bassaganya-Riera J et al. | Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. | 2001 | J. Nutr. | pmid:11533281 |
McKay MC and Worley JF | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546665 |
Kang K and Pariza MW | trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554738 |
Borecký J et al. | Functional reconstitution of Arabidopsis thaliana plant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichia coli. | 2001 | FEBS Lett. | pmid:11566183 |
Gurvitz A et al. | Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. | 2001 | Biochim. Biophys. Acta | pmid:11566445 |
Rainio A et al. | Reduction of linoleic acid inhibition in production of conjugated linoleic acid by Propionibacterium freudenreichii ssp. shermanii. | 2001 | Can. J. Microbiol. | pmid:11575500 |
Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
Poulos SP et al. | Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats. | 2001 | J. Nutr. | pmid:11584096 |
Costarelli V and Sanders TA | Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. | 2001 | Br. J. Nutr. | pmid:11591234 |
Berthoud HR et al. | Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors. | 2001 | Brain Res. | pmid:11595203 |
Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
Goffman FD and Böhme T | Relationship between fatty acid profile and vitamin E content in maize hybrids (Zea mays L.). | 2001 | J. Agric. Food Chem. | pmid:11600056 |
Haastrup A et al. | Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. | 2001 | Hypertension | pmid:11641299 |