Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Naidoo J | Effect of pH on inhibition of plasmid-carrying cultures of Staphylococcus aureus by lipids. | 1981 | J. Gen. Microbiol. | pmid:7320698 |
Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
Kohn A et al. | Interaction of polyunsaturated fatty acids with animal cells and enveloped viruses. | 1980 | Antimicrob. Agents Chemother. | pmid:7235682 |
Iritani N and Ikeda Y | Activation of catalase and other enzymes by corn oil intake. | 1982 | J. Nutr. | pmid:7143106 |
Cuebas D and Schulz H | Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A. | 1982 | J. Biol. Chem. | pmid:7142199 |
Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
Rosing U et al. | Relative fatty acid composition of serum lecithin in the second half of the normal pregnancy. | 1982 | Gynecol. Obstet. Invest. | pmid:7129232 |
Letts V et al. | Synthesis and utilization of fatty acids by wild-type and fatty acid auxotrophs of Caulobacter crescentus. | 1982 | J. Bacteriol. | pmid:7107555 |
Yoo TJ et al. | Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. | 1982 | Cancer Res. | pmid:7105033 |
O'Connell M et al. | The interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine. | 1982 | J. Clin. Endocrinol. Metab. | pmid:7096540 |
Anderson RL | Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. | 1982 | Am. J. Clin. Nutr. | pmid:7081132 |
Okano G and Shimojo T | Utilization of long-chain free fatty acids in white and red muscle of rats. | 1982 | Biochim. Biophys. Acta | pmid:7066350 |
McKerrow JH and Jeong KH | Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. | 1982 | Exp. Parasitol. | pmid:7060706 |
Greenspan MD et al. | Studies on the in vivo synthesis of triacylglycerol in mouse liver. | 1982 | Biochim. Biophys. Acta | pmid:7055591 |
Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
Goodnight SH et al. | Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. | 1982 Mar-Apr | Arteriosclerosis | pmid:7039582 |
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. | 1982 Mar-Apr | Arteriosclerosis | pmid:7039581 | |
Kuriki Y | Effects of unsaturated fatty acids on the morphogenesis of an unsaturated fatty acid auxotroph of Escherichia coli. | 1981 | J. Bacteriol. | pmid:7024246 |
Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |
Singh SP et al. | Absence of effect of prostaglandins on cholesteryl ester metabolism of 3T3 mouse fibroblasts grown in tissue culture. | 1982 | Atherosclerosis | pmid:6952877 |
Hill EG et al. | Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6951178 |
Tobian L et al. | Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl S rats. | 1982 May-Jun | Hypertension | pmid:6950924 |
Verma SP and Wallach DF | Action of ionizing radiation on lipid-protein interaction. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6896453 |
Arudi RL et al. | Purification of oleic acid and linoleic acid. | 1983 | J. Lipid Res. | pmid:6854155 |
Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Simpson HC and Mann JI | Does low dietary intake of linoleic acid predispose to myocardial infarction? | 1982 | Br Med J (Clin Res Ed) | pmid:6814662 |
Claeys M et al. | Characterization of monohydroxylated lipoxygenase metabolites of arachidonic and linoleic acid in rabbit peritoneal tissue. | 1982 | Biochim. Biophys. Acta | pmid:6814493 |
Carreau JP et al. | Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. | 1982 | Ann. Nutr. Metab. | pmid:6814348 |
Härtel B et al. | Self-inactivation by 13-hydroperoxylinoleic acid and lipohydroperoxidase activity of the reticulocyte lipoxygenase. | 1982 | Eur. J. Biochem. | pmid:6813118 |
Abbas MK et al. | Ultrastructure and fatty acid composition of fatty acid-modified Morris 7777 hepatoma cells. | 1982 | Cancer Res. | pmid:6812950 |
Christophersen BO et al. | Studies on the regulation of arachidonic acid synthesis in isolated rat liver cells. | 1982 | Biochim. Biophys. Acta | pmid:6812639 |
Beaudry GA et al. | Stimulation of deacylation in Madin-Darby canine kidney cells. Specificity of deacylation and prostaglandin production in 12-O-tetradecanoylphorbol-13-acetate-treated cells. | 1982 | J. Biol. Chem. | pmid:6809762 |
Denning GM et al. | Effect of fatty acid modification on prostaglandin production by cultured 3T3 cells. | 1982 | J. Lipid Res. | pmid:6808070 |
Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
Shimp JL et al. | The effects of dietary trilinoelaidin on fatty acid and acyl desaturases in rat liver. | 1982 | J. Nutr. | pmid:6802940 |
Kaya K and Miura T | Effects of nitrogen dioxide on fatty acid compositions of red cell membranes, sera, and livers in rats. | 1982 | Environ. Res. | pmid:6802637 |
Rosenblum WI | Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles. | 1982 | Am. J. Physiol. | pmid:6801999 |
Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
Schieberle P et al. | A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. | 1981 | Biochim. Biophys. Acta | pmid:6798993 |
Christophersen BO and Norseth J | Arachidonic acid synthesis in isolated liver cells:" effects of (-)-carnitine and of (+)-decanoylcarnitine. | 1981 | FEBS Lett. | pmid:6796433 |
Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
Kinsella JE et al. | Metabolism of trans fatty acids with emphasis on the effects of trans, trans-octadecadienoate on lipid composition, essential fatty acid, and prostaglandins: an overview. | 1981 | Am. J. Clin. Nutr. | pmid:6794350 |