Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fairfield K | ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. | 2013 | Ann. Intern. Med. | pmid:23689785 |
Giua L et al. | Oxidative modifications of conjugated and unconjugated linoleic acid during heating. | 2013 | Food Chem | pmid:23692753 |
Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
Le Maux S et al. | β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. | 2013 | J. Dairy Sci. | pmid:23684041 |
Jung CH et al. | The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. | 2013 | Metab. Clin. Exp. | pmid:23639572 |
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Dai J et al. | Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. | 2013 | Lipids Health Dis | pmid:23663688 |
Jemia MB et al. | Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). | 2013 | Nat. Prod. Res. | pmid:23082942 |
Bin Q et al. | The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. | 2013 | Lipids | pmid:23065354 |
Ghisolfi J et al. | Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. | 2013 | Public Health Nutr | pmid:23098567 |
Guo J et al. | Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. | 2013 | Animal | pmid:23031491 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
D'Angeli S et al. | Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. | 2013 | New Phytol. | pmid:23078289 |
Bassett JK et al. | Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. | 2013 | Int. J. Cancer | pmid:23575905 |
Garofalo JM et al. | Mouse mammary gland is refractory to the effects of ethanol after natural lactation. | 2013 | Comp. Med. | pmid:23561936 |
Hein LK et al. | Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. | 2013 | J. Lipid Res. | pmid:23564732 |
Zhao Y et al. | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. | 2013 | PLoS ONE | pmid:23565210 |
Høstmark AT and Haug A | Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. | 2013 | Lipids Health Dis | pmid:23521743 |
Han L et al. | Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. | 2013 | Food Chem. Toxicol. | pmid:23959106 |
Aboshi T et al. | Biosynthesis of linoleic acid in Tyrophagus mites (Acarina: Acaridae). | 2013 | Insect Biochem. Mol. Biol. | pmid:23973745 |
Ramirez AM et al. | A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. | 2013 | Lipids | pmid:23893337 |
Adachi S et al. | Increased levels of extracellular dopamine in the nucleus accumbens and amygdala of rats by ingesting a low concentration of a long-chain Fatty Acid. | 2013 | Biosci. Biotechnol. Biochem. | pmid:24200795 |
Özcan T | Accumulation patterns of some seed oil components from wild sources of Turkey. | 2013 | Nat. Prod. Res. | pmid:22233192 |
Herrera-Meza MS et al. | Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. | 2013 | Int J Food Sci Nutr | pmid:23360131 |
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Risé P et al. | Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23910046 |
Chen CS et al. | Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24154509 |
Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
Ngakegni-Limbili AC et al. | Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. | 2013 | J. Sci. Food Agric. | pmid:22692978 |
De Weirdt R et al. | A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. | 2013 | Benef Microbes | pmid:24311313 |
Li XP et al. | Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. | 2013 | Lipids | pmid:23341188 |