Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Luthria DL et al. | Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9144553 |
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Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
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Iwase H et al. | Formation of leukotoxin (9,10-epoxy-12-octadecenoic acid) during the autoxidation of phospholipids promoted by hemoproteins. | 1997 | Biochim. Biophys. Acta | pmid:9084498 |
Iwase H et al. | Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070266 |
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Cogo PE et al. | Simultaneous measurement of the rates of appearance of palmitic and linoleic acid in critically ill infants. | 1997 | Pediatr. Res. | pmid:9029635 |
Hayashi T et al. | Stimulation of cell proliferation and inhibition of gap junctional intercellular communication by linoleic acid. | 1997 | Cancer Lett. | pmid:9029175 |
Staprans I et al. | Oxidized lipids in the diet are incorporated by the liver into very low density lipoprotein in rats. | 1996 | J. Lipid Res. | pmid:9026539 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Kubin A et al. | Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. | 1996 | J. Photochem. Photobiol. B, Biol. | pmid:9002246 |
Kinter M et al. | Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. | 1996 | J. Nutr. | pmid:9001361 |
Tsukamoto S et al. | Effects of bezafibrate on ethanol oxidation in rats. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8986210 |
Hulea SA et al. | Bilirubin sensitized photooxidation of human plasma low density lipoprotein. | 1996 | Biochim. Biophys. Acta | pmid:8982266 |
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Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
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Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |