Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shichiri G et al. | Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. | 1993 | Arch. Biochem. Biophys. | pmid:8099780 |
| Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
| Nakashima Y et al. | Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. | 1993 | J. Lipid Res. | pmid:8094090 |
| Denizot Y et al. | Stimulated human gastric tumor cells (HGT) fail to synthesize eicosanoids. | 1994 | Cancer Lett. | pmid:8076375 |
| Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
| Siguel EN and Lerman RH | Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. | 1994 | Metab. Clin. Exp. | pmid:8052156 |
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| Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
| Imokawa G et al. | Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia. | 1994 | J. Clin. Invest. | pmid:8040295 |
| Batna A and Spiteller G | Oxidation of furan fatty acids by soybean lipoxygenase-1 in the presence of linoleic acid. | 1994 | Chem. Phys. Lipids | pmid:8033289 |
| Kaufman MJ | Comparison of the free radical-scavenging ability of captopril and ascorbic acid in an in-vitro model of lipid oxidation. Implications for reperfusion injury and ACE inhibitor therapy. | 1994 | J. Pharm. Pharmacol. | pmid:8027931 |
| Loidl-Stahlhofen A et al. | Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8025124 |
| Hussey HJ and Tisdale MJ | Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. | 1994 | Br. J. Cancer | pmid:8018542 |
| Woldseth B and Christophersen BO | Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. | 1994 | Biochim. Biophys. Acta | pmid:8011678 |
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| Jack CI et al. | Serum octadeca-9,11 dienoic acid--an assay of free radical activity or a result of bacterial production? | 1994 | Clin. Chim. Acta | pmid:8004784 |
| Simopoulos AP | Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? | 1994 | Free Radic. Biol. Med. | pmid:8001841 |
| Lafond J et al. | Linoleic acid transport by human placental syncytiotrophoblast membranes. | 1994 | Eur. J. Biochem. | pmid:8001588 |
| Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
| Babizhayev MA et al. | L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. | 1994 | Biochem. J. | pmid:7998987 |
| Pourplanche C et al. | Conformational changes of lipoxygenase (LOX) in modified environments. Contribution to the variation in specificity of soybean LOX type 1. | 1994 | J. Biol. Chem. | pmid:7989328 |
| Rose DP et al. | Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro. | 1994 | Cancer Res. | pmid:7987856 |
| Kasayama S et al. | Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins. | 1994 | Cancer Res. | pmid:7987840 |
| Yam D et al. | Insulin and glucose status, tissue and plasma lipids in patients with tumours of the ovary or endometrium: possible dietary implications. | 1994 | Br. J. Cancer | pmid:7981074 |
| Lee KN et al. | Conjugated linoleic acid and atherosclerosis in rabbits. | 1994 | Atherosclerosis | pmid:7980704 |
| Ohrvall M et al. | Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. | 1994 | Atherosclerosis | pmid:7980703 |
| Soltysova T and Bellisle F | Nutrition in ten-year-old children of the Liberec area (Czech Republic). | 1994 | Ann. Nutr. Metab. | pmid:7979168 |
| Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
| Gibson RA et al. | Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. | 1994 | J. Pediatr. | pmid:7965453 |
| Hopewell JW et al. | Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. | 1994 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7961020 |
| Pronczuk A et al. | Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. | 1994 | FASEB J. | pmid:7958627 |
| Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
| Eder K and Kirchgessner M | Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. | 1994 | J. Nutr. | pmid:7931700 |
| Richieri GV et al. | Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. | 1994 | J. Biol. Chem. | pmid:7929039 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Bakken AM et al. | The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. | 1994 | Biochim. Biophys. Acta | pmid:7918598 |
| Roy P et al. | Superoxide generation by lipoxygenase in the presence of NADH and NADPH. | 1994 | Biochim. Biophys. Acta | pmid:7918597 |
| van Kuiken BA and Behnke WD | The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7918595 |
| Watanabe S et al. | A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. | 1994 | J. Nutr. | pmid:7916376 |
| Ulmann L et al. | Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7915142 |
| Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
| Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
| Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
| Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
| Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
| Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
| Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
| Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |