Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Iwase H et al. Formation of leukotoxin (9,10-epoxy-12-octadecenoic acid) during the autoxidation of phospholipids promoted by hemoproteins. 1997 Biochim. Biophys. Acta pmid:9084498
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Hayes KC The linoleic acid content of test diets must be carefully monitored in cholesterol studies. 1997 Am. J. Clin. Nutr. pmid:9094899
Nishizaki T et al. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. 1997 Brain Res. pmid:9099812
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
Nieuwenhuizen WF et al. Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. 1997 Biochemistry pmid:9109655
Ip C and Scimeca JA Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. 1997 Nutr Cancer pmid:9121939
Schneider C et al. A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. 1997 Biochem. Biophys. Res. Commun. pmid:9125182
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Durgam VR and Fernandes G The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. 1997 Cancer Lett. pmid:9215854
Jira W et al. Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis. 1997 Chem. Phys. Lipids pmid:9219348
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Lanson M et al. Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. 1997 J Lipid Mediat Cell Signal pmid:9246607
Hannah JS et al. High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. 1997 Atherosclerosis pmid:9247355
Thomson AB et al. Nutrient uptake into undifferentiated and differentiated HT-29 cells in culture. 1997 Can. J. Physiol. Pharmacol. pmid:9250367
Bosca F et al. Photophysical and photochemical characterization of a photosensitizing drug: a combined steady state photolysis and laser flash photolysis study on carprofen. 1997 Chem. Res. Toxicol. pmid:9250417
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Howlett NG and Avery SV Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. 1997 Appl. Environ. Microbiol. pmid:9251184
Siguel E Essential fatty acid status in patients. 1997 Jul-Aug JPEN J Parenter Enteral Nutr pmid:9252955
Castelli F et al. Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers. 1997 J Pharmacol Toxicol Methods pmid:9253749
Risé P et al. Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. 1997 J. Lipid Res. pmid:9254057
Bakker N et al. Adipose fatty acids and cancers of the breast, prostate and colon: an ecological study. EURAMIC Study Group. 1997 Int. J. Cancer pmid:9259395
Badart-Smook A et al. Fetal growth is associated positively with maternal intake of riboflavin and negatively with maternal intake of linoleic acid. 1997 J Am Diet Assoc pmid:9259708
Feussner I et al. Structural elucidation of oxygenated storage lipids in cucumber cotyledons. Implication of lipid body lipoxygenase in lipid mobilization during germination. 1997 J. Biol. Chem. pmid:9261186
Jenkins TC Ruminal fermentation and nutrient digestion in sheep fed hydroxyethylsoyamide. 1997 J. Anim. Sci. pmid:9263076
Lopez Jimenez JA et al. Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging. 1997 Biochem. Biophys. Res. Commun. pmid:9266846
Fabritius D et al. Biotransformation of linoleic acid with the Candida tropicalis M25 mutant. 1997 Appl. Microbiol. Biotechnol. pmid:9274051
Batna A et al. Lipid peroxidation in presence of ebselen. 1997 Chem. Phys. Lipids pmid:9275309
Usha S and Balakrishnan A c-myc, c-H-ras, and IP3 elevation in 18:2 n-6 dependent proliferation of lung cells. 1997 Jul-Aug In Vitro Cell. Dev. Biol. Anim. pmid:9282304
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
López-Nicolás JM et al. Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. 1997 Biochim. Biophys. Acta pmid:9295158
Hall JA et al. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. 1997 Jul-Aug J. Vet. Intern. Med. pmid:9298479
de Waart FG et al. Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. 1997 Atherosclerosis pmid:9298686
Rusnak A et al. Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production. 1997 J. Bioenerg. Biomembr. pmid:9298714
Moran JH et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. 1997 Toxicol. Appl. Pharmacol. pmid:9299596
Hayakawa F et al. DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. 1997 Biochim. Biophys. Acta pmid:9305782
Chatterjee MT et al. Alterations in cellular lipids may be responsible for the transient nature of the yeast heat shock response. 1997 Microbiology (Reading, Engl.) pmid:9308188
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O'donnell VB and Kühn H Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. 1997 Biochem. J. pmid:9355754
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Anthony FA et al. Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. 1997 Feb-Apr Photodermatol Photoimmunol Photomed pmid:9361122
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Kleinfeld AM et al. Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. 1997 Biochemistry pmid:9369487
Thompson H et al. Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. 1997 Cancer Res. pmid:9371504
Toborek M et al. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. 1997 J. Lipid Res. pmid:9374137
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Kritchevsky D Trans fatty acids and cardiovascular risk. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430386
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Zhou L et al. Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. 1997 Biochim. Biophys. Acta pmid:9434134
Bylund J et al. Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. 1998 J. Pharmacol. Exp. Ther. pmid:9435160
Kaur K et al. (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. 1997 Chem. Res. Toxicol. pmid:9437530
Berry H et al. Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme. 1998 J. Biol. Chem. pmid:9446584
Hamberg M Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. 1998 Arch. Biochem. Biophys. pmid:9448728
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Maheswari SU et al. Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. 1997 Mol. Cell. Biochem. pmid:9450644
van Roermund CW et al. Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions. 1998 EMBO J. pmid:9450993
Dadras SS et al. Implication of hydrogen peroxide generation and apoptosis in the neoplastic transformation of mouse fibroblasts overexpressing peroxisomal fatty acyl-CoA oxidase. 1998 Int. J. Oncol. pmid:9454884
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Pomposiello SI et al. Linoleic acid induces relaxation and hyperpolarization of the pig coronary artery. 1998 Hypertension pmid:9461230
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