Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kashulin PA et al. | Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. | 2000 | Biochem. Soc. Trans. | pmid:11171236 |
Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
Whigham LD et al. | CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171673 |
Inoue I et al. | The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. | 2001 | Metab. Clin. Exp. | pmid:11172467 |
Khosla P and Fungwe TV | Conjugated linoleic acid: effects on plasma lipids and cardiovascular function. | 2001 | Curr. Opin. Lipidol. | pmid:11176200 |
Thomas Yeung CH et al. | Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters. | 2000 | Br. J. Nutr. | pmid:11177212 |
Hughes RK et al. | Mutagenesis and modelling of linoleate-binding to pea seed lipoxygenase. | 2001 | Eur. J. Biochem. | pmid:11179969 |
Burczynski JM et al. | Suppression of lipid peroxidation in adrenal microsomes following ACTH administration to guinea pigs. | 2001 | J. Endocrinol. | pmid:11182771 |
Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Boscá F et al. | Involvement of type I and type II mechanisms in the linoleic acid peroxidation photosensitized by tiaprofenic acid. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:11195846 |
Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
Cavicchioli P et al. | Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208626 |
Garcia JR et al. | Macrophages transfer [14C]-labelled fatty acids to pancreatic islets in culture. | 2001 | Cell Biochem. Funct. | pmid:11223866 |
Ogawa J et al. | Conjugated linoleic acid accumulation via 10-hydroxy-12-octadecaenoic acid during microaerobic transformation of linoleic acid by Lactobacillus acidophilus. | 2001 | Appl. Environ. Microbiol. | pmid:11229917 |
Osman H et al. | Fatty acids bind to the fungal elicitor cryptogein and compete with sterols. | 2001 | FEBS Lett. | pmid:11231013 |
Dandona P et al. | The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. | 2001 | J. Clin. Endocrinol. Metab. | pmid:11232024 |
Sell JL et al. | Metabolizable energy value of conjugated linoleic acid for broiler chicks and laying hens. | 2001 | Poult. Sci. | pmid:11233010 |
Du M et al. | Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. | 2001 | Poult. Sci. | pmid:11233015 |
Baer RJ et al. | Composition and properties of milk and butter from cows fed fish oil. | 2001 | J. Dairy Sci. | pmid:11233018 |
Hauville C et al. | Radiation induced peroxidation of polyunsaturated fatty acids: recent results on formation of hydroperoxides. | 2001 | Can. J. Physiol. Pharmacol. | pmid:11233566 |
Aydin R et al. | Olive oil prevents the adverse effects of dietary conjugated linoleic acid on chick hatchability and egg quality. | 2001 | J. Nutr. | pmid:11238762 |
Igarashi M and Miyazawa T | The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. | 2001 | Biochim. Biophys. Acta | pmid:11239819 |
George P et al. | Phospholipids reacylation and palmitoylcoa control tumour necrosis factor-alpha sensitivity. | 2001 | Cytokine | pmid:11243703 |
Slim R et al. | The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11243918 |
Boudreau MD et al. | Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. | 2001 | Cancer Res. | pmid:11245439 |
Loreau O et al. | Sequential substitution of 1,2-dichloro-ethene: a convenient stereoselective route to (9Z,11E)-, (10E,12Z)- and (10Z,12Z)-. | 2001 | Chem. Phys. Lipids | pmid:11245835 |
Michels KB et al. | Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women. | 2001 | Int. J. Cancer | pmid:11251982 |
Korotkova M et al. | Maternal essential fatty acid deficiency depresses serum leptin levels in suckling rat pups. | 2001 | J. Lipid Res. | pmid:11254747 |
Higdon JV et al. | Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. | 2001 | J. Lipid Res. | pmid:11254753 |
Warner K et al. | Effect of oleic and linoleic acids on the production of deep-fried odor in heated triolein and trilinolein. | 2001 | J. Agric. Food Chem. | pmid:11262047 |
Bassaganya-Riera J et al. | Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth, empty body composition, and immune competence. | 2001 | J. Anim. Sci. | pmid:11263832 |
Ponticelli F et al. | Synthesis and antiperoxidant activity of new phenolic O-glycosides. | 2001 | Carbohydr. Res. | pmid:11269397 |
Kumamoto M et al. | Effects of pH and metal ions on antioxidative activities of catechins. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11272815 |
Cunnane SC et al. | Beta-oxidation of linoleate in obese men undergoing weight loss. | 2001 | Am. J. Clin. Nutr. | pmid:11273844 |
Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
Freeman VL et al. | Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? | 2001 | Am. J. Clin. Nutr. | pmid:11273858 |
Lim KT et al. | Antioxidant activity of a Rhus verniciflua Stokes ethanol extract. | 2001 | Food Chem. Toxicol. | pmid:11278054 |
Mogul R and Holman TR | Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. | 2001 | Biochemistry | pmid:11284695 |
Poirier H et al. | Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. | 2001 | Biochem. J. | pmid:11284737 |
Ikeda I et al. | Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia. | 2001 | J. Nutr. | pmid:11285319 |
Chouinard PY et al. | Effect of dietary lipid source on conjugated linoleic acid concentrations in milk fat. | 2001 | J. Dairy Sci. | pmid:11286421 |
Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
Palmantier R et al. | Cis-polyunsaturated fatty acids stimulate beta1 integrin-mediated adhesion of human breast carcinoma cells to type IV collagen by activating protein kinases C-epsilon and -mu. | 2001 | Cancer Res. | pmid:11289113 |
Moran JH et al. | Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. | 2001 | Toxicol. Appl. Pharmacol. | pmid:11298501 |
pmid:11301062 | ||||
Mpagi JL et al. | Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. | 2000 | Am. J. Trop. Med. Hyg. | pmid:11304059 |
Wulferink M et al. | T cells ignore aniline, a prohapten, but respond to its reactive metabolites generated by phagocytes: possible implications for the pathogenesis of toxic oil syndrome. | 2001 | Chem. Res. Toxicol. | pmid:11304127 |