Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ma C et al. | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. | 2016 | Nature | pmid:26934227 |
Padayachee T et al. | The Detection of Metabolite-Mediated Gene Module Co-Expression Using Multivariate Linear Models. | 2016 | PLoS ONE | pmid:26918614 |
Hellström F et al. | Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain. | 2016 | BMC Musculoskelet Disord | pmid:26916287 |
Ito J et al. | A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. | 2016 | Anal Bioanal Chem | pmid:27549797 |
Rosenblat M et al. | Nitro-Oleic Acid Reduces J774A.1 Macrophage Oxidative Status and Triglyceride Mass: Involvement of Paraoxonase2 and Triglyceride Metabolizing Enzymes. | 2016 | Lipids | pmid:27344666 |
Zhang YH et al. | The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. | 2016 | PLoS ONE | pmid:27780226 |
Rodrigues HG et al. | Oral Administration of Linoleic Acid Induces New Vessel Formation and Improves Skin Wound Healing in Diabetic Rats. | 2016 | PLoS ONE | pmid:27764229 |
Kojima K et al. | A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. | 2016 | Appl. Microbiol. Biotechnol. | pmid:27704180 |
Ishida K and Jolly ER | Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. | 2016 | PLoS Negl Trop Dis | pmid:27611863 |
Wang S et al. | Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:26879142 |