| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sasaki T et al. | Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. | 1999 | Biochim. Biophys. Acta | pmid:9989281 |
| Zhou L and Nilsson A | Fasting increases tissue uptake and interconversion of plasma unesterified linoleic acid in guinea pigs. | 1999 | Biochim. Biophys. Acta | pmid:9989279 |
| Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
| Black PN | The prevalence of allergic disease and linoleic acid in the diet. | 1999 | J. Allergy Clin. Immunol. | pmid:9949330 |
| Chyb S et al. | Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. | 1999 | Nature | pmid:9930700 |
| Kalivianakis M et al. | Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. | 1999 | Am. J. Clin. Nutr. | pmid:9925134 |
| Allman-Farinelli MA et al. | Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. | 1999 | Atherosclerosis | pmid:9920517 |
| Pohl CH et al. | Oxylipin formation in fungi: biotransformation of arachidonic acid to 3-hydroxy-5,8-tetradecadienoic acid by Mucor genevensis. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9918790 |
| Satory DL and Smith SB | Conjugated linoleic acid inhibits proliferation but stimulates lipid filling of murine 3T3-L1 preadipocytes. | 1999 | J. Nutr. | pmid:9915881 |
| Hayek MG et al. | Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. | 1999 | J. Nutr. | pmid:9915872 |
| Mahfouz MM and Kummerow FA | Hydrogenated fat high in trans monoenes with an adequate level of linoleic acid has no effect on prostaglandin synthesis in rats. | 1999 | J. Nutr. | pmid:9915870 |
| O'Donnell VB et al. | Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion. | 1999 | Chem. Res. Toxicol. | pmid:9894022 |
| Hennig B et al. | Linoleic acid amplifies polychlorinated biphenyl-mediated dysfunction of endothelial cells. | 1999 | J. Biochem. Mol. Toxicol. | pmid:9890193 |
| Tsimikas S et al. | LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9888874 |
| Akeo K and Hiramitsu T | Changes in lipid peroxide level in retinal pigment epithelial cells in vitro upon addition of linoleic acids or linoleic acid hydroperoxides under varying concentrations of oxygen. | 1998 | Pigment Cell Res. | pmid:9877104 |
| Kim EJ et al. | Development of a serum-free medium for the production of humanized antibody from Chinese hamster ovary cells using a statistical design. | 1998 Nov-Dec | In Vitro Cell. Dev. Biol. Anim. | pmid:9870524 |
| Blaauwwiekel EE et al. | Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion. | 1998 | Diabet. Med. | pmid:9868977 |
| Hudson JA et al. | Hydration of linoleic acid by bacteria isolated from ruminants. | 1998 | FEMS Microbiol. Lett. | pmid:9868771 |
| Jarmuszkiewicz W et al. | Linoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondria during resting, phosphorylating, and progressively uncoupled respiration. | 1998 | J. Biol. Chem. | pmid:9857016 |
| Spiteller G | Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases. | 1998 | Chem. Phys. Lipids | pmid:9853364 |
| Nestel PJ et al. | Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. | 1998 | Am. J. Clin. Nutr. | pmid:9846846 |
| Oyama Y et al. | Protective actions of 5'-n-alkylated curcumins on living cells suffering from oxidative stress. | 1998 | Eur. J. Pharmacol. | pmid:9845274 |
| Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844997 |
| Phifer CB and Berthoud HR | Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. | 1998 | Am. J. Physiol. | pmid:9841547 |
| Iwase H et al. | Calcium is required for quasi-lipoxygenase activity of hemoproteins. | 1998 | Free Radic. Biol. Med. | pmid:9840740 |
| Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
| Morita Y et al. | Involvement of lipid peroxidation in free fatty acid-induced isolated rat pancreatic acinar cell injury. | 1998 | Pancreas | pmid:9821180 |
| Broun P et al. | Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. | 1998 | Science | pmid:9812895 |
| Masia A et al. | Enrichment with a polyunsaturated fatty acid enhances the survival of Saccharomyces cerevisiae in the presence of tributyltin. | 1998 | FEMS Microbiol. Lett. | pmid:9809434 |
| Cunnane SC et al. | Substantial carbon recycling from linoleate into products of de novo lipogenesis occurs in rat liver even under conditions of extreme dietary linoleate deficiency. | 1998 | J. Lipid Res. | pmid:9799813 |
| Bretillon L et al. | Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. | 1998 | J. Lipid Res. | pmid:9799809 |
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| Hu ZY et al. | cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. | 1998 | Biochim. Biophys. Acta | pmid:9784625 |
| Iwamoto S et al. | Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. | 1998 | Nutr Cancer | pmid:9770727 |
| Obukowicz MG et al. | Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9765335 |
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| Kuratko CN and Constante BJ | Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells. | 1998 | Cancer Lett. | pmid:9751273 |
| Kanazawa K and Ashida H | Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. | 1998 | Biochim. Biophys. Acta | pmid:9748650 |
| Kanazawa K and Ashida H | Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. | 1998 | Biochim. Biophys. Acta | pmid:9748647 |
| Berdeaux O et al. | In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. | 1998 | Mol. Cell. Biochem. | pmid:9746207 |
| Romijn D et al. | A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. | 1998 | Ann. Nutr. Metab. | pmid:9745111 |
| Sluse FE et al. | Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria. | 1998 | FEBS Lett. | pmid:9744802 |
| Rodriguez A et al. | Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspects. | 1998 | J. Lipid Res. | pmid:9741695 |
| Liu JH et al. | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. | 1998 | Planta Med. | pmid:9741298 |
| Fidler N et al. | Effects of human milk pasteurization and sterilization on available fat content and fatty acid composition. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9740204 |
| Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
| Wilson TA et al. | Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. | 1998 | Atherosclerosis | pmid:9733225 |
| West DB et al. | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. | 1998 | Am. J. Physiol. | pmid:9728060 |
| Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
| Konrad SD et al. | Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. | 1998 | Biochim. Biophys. Acta | pmid:9714781 |
| Butovich IA et al. | Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712698 |
| Ondrias K et al. | Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes. | 1998 | Physiol Res | pmid:9706995 |
| KmonÃcková E et al. | Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions. | 1998 | Physiol Res | pmid:9706993 |
| Yamaguchi H et al. | High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin. | 1998 | J. Dermatol. Sci. | pmid:9697049 |
| Goodrich-Tanrikulu M et al. | Changes in fatty acid composition of Neurospora crassa accompany sexual development and ascospore germination. | 1998 | Microbiology (Reading, Engl.) | pmid:9695905 |
| Hsu AF et al. | Characterization of soybean lipoxygenase immobilized in cross-linked phyllosilicates. | 1998 | Biotechnol. Appl. Biochem. | pmid:9693089 |
| Letawe C et al. | Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. | 1998 | Clin. Exp. Dermatol. | pmid:9692305 |
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| Kang LT and Vanderhoek JY | Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. | 1998 | J. Lipid Res. | pmid:9684751 |
| Demmelmair H et al. | Metabolism of U13C-labeled linoleic acid in lactating women. | 1998 | J. Lipid Res. | pmid:9684741 |
| Kelly ML et al. | Effect of intake of pasture on concentrations of conjugated linoleic acid in milk of lactating cows. | 1998 | J. Dairy Sci. | pmid:9684170 |
| Guarini P et al. | Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. | 1998 | Inflammation | pmid:9675609 |
| Pitchumoni S et al. | Reoxygenation injury affects isolated islet response to fatty acid stimulation. | 1998 | Metab. Clin. Exp. | pmid:9667226 |
| Zock PL and Katan MB | Linoleic acid intake and cancer risk: a review and meta-analysis. | 1998 | Am. J. Clin. Nutr. | pmid:9665108 |
| Erickson KL | Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? | 1998 | Am. J. Clin. Nutr. | pmid:9665090 |
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| Hughes RK et al. | Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. | 1998 | Biochem. J. | pmid:9639559 |
| Battu S et al. | Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. | 1998 | Biochim. Biophys. Acta | pmid:9630716 |
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| Kelly ML et al. | Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. | 1998 | J. Nutr. | pmid:9566998 |
| Marra F et al. | Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. | 1998 | J. Hepatol. | pmid:9566835 |
| Yehuda S et al. | Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. | 1998 | Neurochem. Res. | pmid:9566600 |
| Kowaltowski AJ et al. | Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. | 1998 | FEBS Lett. | pmid:9559650 |
| Akamatsu H and Horio T | The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. | 1998 | Dermatology (Basel) | pmid:9557235 |
| Rosenfield RL et al. | Mechanisms of androgen induction of sebocyte differentiation. | 1998 | Dermatology (Basel) | pmid:9557223 |
| Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
| Kataoka K et al. | Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. | 1998 | Pancreas | pmid:9548669 |
| Li-Stiles B et al. | Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes. | 1998 | J. Lipid Res. | pmid:9548589 |
| Liu SX et al. | Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. | 1998 | Atherosclerosis | pmid:9544730 |
| Matthys LA and Widmaier EP | Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis. | 1998 | Horm. Metab. Res. | pmid:9543689 |
| Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
| Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
| Liang JF and Akaike T | Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. | 1998 | J. Biochem. | pmid:9538194 |