Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Rosenfield RL et al. Mechanisms of androgen induction of sebocyte differentiation. 1998 Dermatology (Basel) pmid:9557223
Akamatsu H and Horio T The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. 1998 Dermatology (Basel) pmid:9557235
Kowaltowski AJ et al. Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. 1998 FEBS Lett. pmid:9559650
Yehuda S et al. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. 1998 Neurochem. Res. pmid:9566600
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Kelly ML et al. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. 1998 J. Nutr. pmid:9566998
Hill EM et al. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9569236
Lee M et al. Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. 1998 Science pmid:9572738
Hamberg M et al. Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction. 1998 J. Biol. Chem. pmid:9582346
Peterson DB Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. 1998 Nutrition pmid:9583379
Kambayashi Y et al. Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. 1998 Biochem. Biophys. Res. Commun. pmid:9588178
Dokko RC et al. Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. 1998 Int. J. Biochem. Cell Biol. pmid:9597754
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Geetha T et al. Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. 1998 Pharmacol. Res. pmid:9602466
Kleinfeld AM et al. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. 1998 Biochemistry pmid:9609694
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Ohnishi M et al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. 1998 Phytochemistry pmid:9611825
Liu KL and Belury MA Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes. 1998 Cancer Lett. pmid:9619853