| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Song E et al. | Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. | 2014 | J Am Heart Assoc | pmid:24721803 |
| Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
| Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
| Bernhard W et al. | Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. | 2014 | Eur J Nutr | pmid:24464176 |
| Jacob RH et al. | Phenotypic characterisation of colour stability of lamb meat. | 2014 | Meat Sci. | pmid:23415827 |
| Petzinger C et al. | Lipid metabolic dose response to dietary alpha-linolenic acid in monk parrot (Myiopsitta monachus). | 2014 | Lipids | pmid:24293226 |
| Hodson L et al. | Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. | 2014 | J. Nutr. | pmid:24225449 |
| Baek JH et al. | Lithium tremor revisited: pathophysiology and treatment. | 2014 | Acta Psychiatr Scand | pmid:23834617 |
| Corrêa RC et al. | Antioxidant and rheological properties of guava jam with added concentrated grape juice. | 2014 | J. Sci. Food Agric. | pmid:23696312 |
| Bagai S et al. | Lipid-modified polyethylenimine-mediated DNA attraction evaluated by molecular dynamics simulations. | 2014 | J Phys Chem B | pmid:24918771 |
| Tang KS | Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. | 2014 | Lipids Health Dis | pmid:25522984 |
| Qin G et al. | Evolution of the aroma volatiles of pear fruits supplemented with fatty acid metabolic precursors. | 2014 | Molecules | pmid:25474290 |
| Farvid MS et al. | Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. | 2014 | Circulation | pmid:25161045 |
| Harris WS and Shearer GC | Omega-6 fatty acids and cardiovascular disease: friend, not foe? | 2014 | Circulation | pmid:25161044 |
| Saito HE et al. | Incorporation of exogenous fatty acids protects Enterococcus faecalis from membrane-damaging agents. | 2014 | Appl. Environ. Microbiol. | pmid:25128342 |
| Wu JH et al. | Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. | 2014 | Circulation | pmid:25124495 |
| Phan CW et al. | Intrastrain comparison of the chemical composition and antioxidant activity of an edible mushroom, Pleurotus giganteus, and its potent neuritogenic properties. | 2014 | ScientificWorldJournal | pmid:25121118 |
| Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
| van Schalkwijk DB et al. | Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation. | 2014 | PLoS ONE | pmid:25049048 |
| Beavers WN et al. | ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. | 2014 | J. Am. Chem. Soc. | pmid:25034362 |
| Shimamoto C et al. | Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. | 2014 | Hum. Mol. Genet. | pmid:25027319 |
| Hellstrand S et al. | Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. | 2014 | J. Nutr. | pmid:25008580 |
| Hester AG et al. | Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. | 2014 | J. Biol. Chem. | pmid:24962583 |
| Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
| Moate PJ et al. | Grape marc reduces methane emissions when fed to dairy cows. | 2014 | J. Dairy Sci. | pmid:24952778 |
| Mesti T et al. | Metabolic impact of anti-angiogenic agents on U87 glioma cells. | 2014 | PLoS ONE | pmid:24922514 |
| Herchi W et al. | Flaxseed hull: Chemical composition and antioxidant activity during development. | 2014 | J Oleo Sci | pmid:24919478 |
| Woyda-Ploszczyca AM and Jarmuszkiewicz W | Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. | 2014 | PLoS ONE | pmid:24904988 |
| Maruyama H et al. | Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. | 2014 | Lipids Health Dis | pmid:24885871 |
| Nosaka S and Miyazawa M | Characterization of volatile components and odor-active compounds in the oil of edible mushroom Boletopsis leucomelas. | 2014 | J Oleo Sci | pmid:24881770 |
| Chilton FH et al. | Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. | 2014 | Nutrients | pmid:24853887 |
| Saito H and Ishikawa S | Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. | 2014 | J Oleo Sci | pmid:24829130 |
| Verlotta A and Trono D | Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. | 2014 | Protein Expr. Purif. | pmid:24925645 |
| Yang B et al. | Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. | 2014 | J. Appl. Microbiol. | pmid:24750362 |
| Mouokeu RS et al. | Antifungal and antioxidant activity of Crassocephalum bauchiense (Hutch.) Milne-Redh ethyl acetate extract and fractions (Asteraceae). | 2014 | BMC Res Notes | pmid:24742210 |
| Buehlmann C et al. | Desert ants locate food by combining high sensitivity to food odors with extensive crosswind runs. | 2014 | Curr. Biol. | pmid:24726153 |
| Arcan I and YemenicioÄŸlu A | Controlled release properties of zein-fatty acid blend films for multiple bioactive compounds. | 2014 | J. Agric. Food Chem. | pmid:25025594 |
| Rodriguez MA et al. | Concordance analysis between estimation methods of milk fatty acid content. | 2014 | Food Chem | pmid:24629954 |
| Spartano NL et al. | Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages. | 2014 | Lipids | pmid:24595513 |
| Scalerandi MV et al. | Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. | 2014 | Nutr Hosp | pmid:24559004 |
| Asselin C et al. | Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. | 2014 | Redox Biol | pmid:24494189 |
| Mouradian M et al. | Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24374147 |
| Nehdi IA et al. | Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product. | 2014 | J. Food Sci. | pmid:24666023 |
| Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
| Sarath Josh MK et al. | Phthalates efficiently bind to human peroxisome proliferator activated receptor and retinoid X receptor α, β, γ subtypes: an in silico approach. | 2014 | J Appl Toxicol | pmid:23843199 |
| Negrini R et al. | Influence of electrostatic interactions on the release of charged molecules from lipid cubic phases. | 2014 | Langmuir | pmid:24673189 |
| Choi JI et al. | Development of microalga Scenedesmus dimorphus mutant with higher lipid content by radiation breeding. | 2014 | Bioprocess Biosyst Eng | pmid:24871276 |
| Wright CR and Setzer WN | Chemical composition of volatiles from Opuntia littoralis, Opuntia ficus-indica, and Opuntia prolifera growing on Catalina Island, California. | 2014 | Nat. Prod. Res. | pmid:24354326 |
| Guo HH et al. | XsFAD2 gene encodes the enzyme responsible for the high linoleic acid content in oil accumulated in Xanthoceras sorbifolia seeds. | 2014 | J. Sci. Food Agric. | pmid:23775588 |
| Huang X et al. | Serum fatty acid patterns, insulin sensitivity and the metabolic syndrome in individuals with chronic kidney disease. | 2014 | J. Intern. Med. | pmid:24011327 |
| Choque B et al. | Linoleic acid: between doubts and certainties. | 2014 | Biochimie | pmid:23900039 |
| Radice M et al. | Chemical characterization and antioxidant activity of Amazonian (Ecuador) Caryodendron orinocense Karst. and Bactris gasipaes Kunth seed oils. | 2014 | J Oleo Sci | pmid:25391685 |
| Garrel G et al. | Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. | 2014 | Endocrinology | pmid:24248462 |
| Kim JY et al. | Role of moisture on the lipid oxidation determined by D(2)O in a linoleic acid model system. | 2014 | Food Chem | pmid:24176324 |
| Usami A et al. | Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus). | 2014 | J Oleo Sci | pmid:24919476 |
| Sponton OE et al. | Effect of limited enzymatic hydrolysis on linoleic acid binding properties of β-lactoglobulin. | 2014 | Food Chem | pmid:24176383 |
| Dal Bosco A et al. | Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. | 2014 | Meat Sci. | pmid:24036258 |
| Su MH et al. | Chemical composition of seed oils in native Taiwanese Camellia species. | 2014 | Food Chem | pmid:24629982 |
| López-Cervantes J et al. | Effect of solvents and methods of stirring in extraction of lycopene, oleoresin and fatty acids from over-ripe tomato. | 2014 | Int J Food Sci Nutr | pmid:24111501 |
| Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
| Yavin E et al. | Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. | 2014 | Biochim. Biophys. Acta | pmid:24960100 |
| Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
| Huang FC et al. | Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. | 2014 | Appl. Environ. Microbiol. | pmid:24242247 |
| López A et al. | Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model. | 2014 | J Mech Behav Biomed Mater | pmid:24508711 |
| Larsson N et al. | Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans. | 2014 | Eur. Respir. J. | pmid:24036245 |
| Yang Y et al. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. | 2014 | Lipids | pmid:24777581 |
| Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
| Bonferoni MC et al. | Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid. | 2014 | Eur J Pharm Biopharm | pmid:24384070 |
| Stoffel W et al. | Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. | 2014 | EMBO Rep. | pmid:24378641 |
| González-AbuÃn N et al. | Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24371039 |
| Öztürk M et al. | The fatty acid compositions of several plant seed oils belong to Leguminosae and Umbelliferae families. | 2014 | Environ Monit Assess | pmid:24357269 |
| Choi JS et al. | In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. | 2014 | Biol. Pharm. Bull. | pmid:24389480 |
| Chevrot M et al. | Obesity interferes with the orosensory detection of long-chain fatty acids in humans. | 2014 | Am. J. Clin. Nutr. | pmid:24522446 |
| Barua P et al. | Seed oils from non-conventional sources in north-east India: potential feedstock for production of biodiesel. | 2014 | Nat. Prod. Res. | pmid:24483850 |
| Cho Y et al. | Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24495951 |
| Matthaus B and Özcan MM | Fatty acid and tocopherol contents of several soybean oils. | 2014 | Nat. Prod. Res. | pmid:24499198 |
| Dailey MJ et al. | Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24452547 |
| Shen J et al. | A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. | 2014 | J. Exp. Bot. | pmid:24453226 |
| Mulligan CM et al. | Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. | 2014 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:24418793 |
| Oh YT et al. | Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. | 2014 | Endocrinology | pmid:24424035 |
| Ozdener MH et al. | CD36- and GPR120-mediated Ca²⺠signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. | 2014 | Gastroenterology | pmid:24412488 |
| Paulsen SJ et al. | Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. | 2014 | PLoS ONE | pmid:24520357 |
| Youn K et al. | Oleic acid and linoleic acid from Tenebrio molitor larvae inhibit BACE1 activity in vitro: molecular docking studies. | 2014 | J Med Food | pmid:24548007 |
| Ambrozova JV et al. | Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. | 2014 | Molecules | pmid:24566307 |
| Bazongo P et al. | Characteristics, composition and oxidative stability of Lannea microcarpa seed and seed oil. | 2014 | Molecules | pmid:24566330 |
| Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |
| Darling RA et al. | Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24760994 |
| Nardi F et al. | Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. | 2014 | PLoS ONE | pmid:24632852 |
| Hall TD et al. | Changes during leaf expansion of ΦPSII temperature optima in Gossypium hirsutum are associated with the degree of fatty acid lipid saturation. | 2014 | J. Plant Physiol. | pmid:24594393 |
| Ogorodnikova AV et al. | Screening of divinyl ether synthase activity in nonphotosynthetic tissue of asparagales. | 2013 Mar-Apr | Dokl. Biochem. Biophys. | pmid:23657662 |
| Thomas CP et al. | Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. | 2013 Feb-Mar | Chem. Phys. Lipids | pmid:23352713 |
| Sy C et al. | Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. | 2013 | Food Funct | pmid:23411789 |
| Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
| Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
| Le Maux S et al. | β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. | 2013 | J. Dairy Sci. | pmid:23684041 |
| Calder PC | Old study sheds new light on the fatty acids and cardiovascular health debate. | 2013 | BMJ | pmid:23386269 |
| Bassett JK et al. | Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. | 2013 | Int. J. Cancer | pmid:23575905 |
| Han L et al. | Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. | 2013 | Food Chem. Toxicol. | pmid:23959106 |
| Herrera-Meza MS et al. | Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. | 2013 | Int J Food Sci Nutr | pmid:23360131 |
| Chen CS et al. | Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24154509 |