| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:28398349 | ||||
| pmid:28367773 | ||||
| pmid:26890090 | ||||
| pmid:26510334 | ||||
| pmid:26151719 | ||||
| pmid:25687457 | ||||
| pmid:25646690 | ||||
| pmid:25329876 | ||||
| pmid:25326184 | ||||
| pmid:25301203 | ||||
| pmid:25296624 | ||||
| pmid:24911614 | ||||
| pmid:24905048 | ||||
| pmid:26919787 | ||||
| pmid:24582933 | ||||
| pmid:28552618 | ||||
| pmid:15428914 | ||||
| pmid:28401382 | ||||
| pmid:26560362 | ||||
| pmid:26142845 | ||||
| pmid:26523477 | ||||
| pmid:24611378 | ||||
| pmid:28528080 | ||||
| pmid:27779383 | ||||
| pmid:27450794 | ||||
| pmid:27370696 | ||||
| pmid:27364827 | ||||
| pmid:27350414 | ||||
| pmid:26094213 | ||||
| pmid:26912357 | ||||
| pmid:19200116 | ||||
| pmid: | ||||
| Yao X et al. | Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. | Prostaglandins Other Lipid Mediat. | pmid:25841349 | |
| pmid:12790685 | ||||
| Fraenkel G and Blewett M | Linoleic acid and arachidonic acid in the metabolism of two insects, Ephestia kuehniella (Lep.) and Tenebrio molitor (Col.). | 1947 | Biochem. J. | pmid:16748194 |
| MEDES G et al. | Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. | 1951 | Arch. Biochem. Biophys. | pmid:14847665 |
| Mead JF | The Irradiation-Induced Autoxidation of Linoleic Acid. | 1952 | Science | pmid:17749056 |
| TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
| KHAN NA | Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. | 1953 | Arch. Biochem. Biophys. | pmid:13058378 |
| TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
| BUTCHER EO | The penetration of fat and fatty acid into the skin of the rat. | 1953 | J. Invest. Dermatol. | pmid:13069840 |
| BLOMSTRAND R | The intestinal absorption of linoleic-1-14C acid. | 1954 | Acta Physiol. Scand. | pmid:13228101 |
| KHAN NA | Infrared studies on initiation of the autoxidation of some fatty acid esters with and without light-sensitized chlorophyll, ultraviolet light and lipoxidase. | 1955 | Biochim. Biophys. Acta | pmid:14363243 |
| CHENG AL et al. | The effect of fat level of the diet on general nutrition. XV. Comparison of the protective effect of linoleic acid and linolenic acid against multiple sublethal doses of x-irradiation in the rat. | 1955 | J. Nutr. | pmid:14368364 |
| PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
| MEAD JF et al. | Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. | 1956 | J. Biol. Chem. | pmid:13278347 |
| STEINBERG G et al. | Metabolism of essential fatty acids. IV. Incorporation of linoleate into arachidonic acid. | 1956 | J. Biol. Chem. | pmid:13319343 |
| SIDDIQI AM and TAPPEL AL | Catalysis of linoleate oxidation by pea lipoxidase. | 1956 | Arch. Biochem. Biophys. | pmid:13283592 |
| FISHER H and LEVEILLE GA | Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. | 1957 | J. Nutr. | pmid:13476240 |
| HORGAN VJ et al. | Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. | 1957 | Biochem. J. | pmid:13488907 |
| TOOKEY HL et al. | Coupled oxidation of carotene and linoleate catalyzed by lipoxidase. | 1958 | J. Biol. Chem. | pmid:13502374 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
| WIESE HF et al. | Essential fatty acids in infant nutrition. I. Linoleic acid requirement in terms of serum di-, tri- and tetraenoic acid levels. | 1958 | J. Nutr. | pmid:13611579 |
| HANSEN AE et al. | Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. | 1958 | J. Nutr. | pmid:13621281 |
| KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
| HAINING JL and AXELROD B | Induction period in the lipoxidase-catalyzed oxidation of linoleic acid and its abolition by substrate peroxide. | 1958 | J. Biol. Chem. | pmid:13549410 |
| OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |
| HAUGE JG and NICOLAYSEN R | The serum cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaemic rats. | 1959 | Acta Physiol. Scand. | pmid:13626601 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
| FULD H and HORWICH L | Xanthomatous biliary cirrhosis treated with ethyl linoleate. | 1959 | Lancet | pmid:13655619 |
| PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
| YUAN C and BLOCH K | Conversion of oleic acid to linoleic acid. | 1961 | J. Biol. Chem. | pmid:13787544 |
| JAGANNATHAN SN | Effect of feeding different fat mixtures providing the same amount of linoleic acid, on serum cholesterol levels in monkeys and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450883 |
| JAGANNATHAN SN | Effect of feeding fat blends of hydrogenated groundnut (peanut) fat and cottonseed oil containing different levels of linoleic acid on serum choles terol levels in monkeys (Macaca radiata) and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450884 |
| DEYKIN D and GOODMAN DS | The hydrolysis of long-chain fatty acid esters of cholesterol with rat liver enzymes. | 1962 | J. Biol. Chem. | pmid:14027461 |
| SUEYOSHI Y and NAGAO Y | Studies on the linoleic acid contents in the phospholipids of the sarcoma. | 1962 | Keio J Med | pmid:13918168 |
| VIOQUE E and HOLMAN RT | Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. | 1962 | Arch. Biochem. Biophys. | pmid:13997422 |
| WILSON JD | Relation between dietary cholesterol and bile acid excretion in the rat. | 1962 | Am. J. Physiol. | pmid:14001040 |
| CASTER WO et al. | Determination of linoleate requirement of swine by a new method of estimating nutritional requirement. | 1962 | J. Nutr. | pmid:14019220 |
| SUEYOSHI Y and NAGAO Y | The influence of linoleic acid upon the growth of transplanted sarcoma. | 1962 | Keio J Med | pmid:13979090 |
| MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. | 1963 | Biochem. J. | pmid:14071526 |
| MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. | 1963 | Biochem. J. | pmid:14071527 |
| STEIN O and STEIN Y | METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. | 1963 | Biochim. Biophys. Acta | pmid:14085937 |
| LEAT WM | FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. | 1963 | Biochem. J. | pmid:14097364 |
| YOUNG RJ and GARRETT RL | EFFECT OF OLEIC AND LINOLEIC ACIDS ON THE ABSORPTION OF SATURATED FATTY ACIDS IN THE CHICK. | 1963 | J. Nutr. | pmid:14100991 |
| JOHNSON RC and GARY ND | NUTRITION OF LEPTOSPIRA POMONA. II. FATTY ACID REQUIREMENTS. | 1963 | J. Bacteriol. | pmid:14044026 |
| BENNETT JR | THE ESTERIFICATION OF CHOLESTEROL BY RAT-LIVER PREPARATIONS. | 1963 | Biochim. Biophys. Acta | pmid:14067620 |
| HAYASHIDA T and PORTMAN OW | CHANGES IN SUCCINIC DEHYDROGENASE ACTIVITY AND FATTY ACID COMPOSITION OF RAT LIVER MITOCHONDRIA IN ESSENTIAL FATTY ACID DEFICIENCY. | 1963 | J. Nutr. | pmid:14068923 |
| PELUFFO RO et al. | ACTION OF LINOLEIC AND ARACHIDONIC ACIDS UPON THE EICOSATRIENOIC ACID LEVEL IN RAT HEART AND LIVER. | 1963 | J. Nutr. | pmid:14068924 |
| PORTMAN OW and SUGANO M | THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. | 1963 | Arch. Biochem. Biophys. | pmid:14072510 |
| MATSUSHITA S et al. | CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS. | 1963 | Arch. Biochem. Biophys. | pmid:14072524 |
| HUGHES G et al. | LINOLEIC ACID--AN ESSENTIAL NUTRIENT: ITS CONTENT IN INFANT FORMULAS AND PRECOOKED CEREALS. | 1963 | Clin Pediatr (Phila) | pmid:14072730 |
| SWELL L et al. | DYNAMIC ASPECTS OF CHOLESTEROL ESTER METABOLISM IN RABBITS WITH ATHEROSCLEROSIS. | 1963 | J. Nutr. | pmid:14083242 |
| ERWIN ES and STERNER W | DIETARY LIPIDS AND FATTY ACID DEPOSITION IN VARIOUS CALF TISSUES. | 1963 | Am. J. Physiol. | pmid:14084975 |
| KAI M et al. | FATTY ACID COMPOSITION OF LECITHIN FROM BEEF BRAIN AND EGG YOLK. | 1963 | J. Biochem. | pmid:14089733 |
| LEVEILLE GA et al. | FATTY ACID COMPOSITION OF PLASMA AND LIVER LIPID COMPONENTS AS INFLUENCED BY DIET IN THE GROWING CHICK. | 1963 | J. Nutr. | pmid:14100995 |
| CENTURY B et al. | INTERRELATIONSHIPS OF DIETARY LIPIDS UPON FATTY ACID COMPOSITION OF BRAIN MITOCHONDRIA, ERYTHROCYTES AND HEART TISSUE IN CHICKS. | 1963 | Am. J. Clin. Nutr. | pmid:14101397 |
| LESSELL S and KUWABARA T | LINOLEIC ACID IN INFANT NUTRITION. | 1963 | Br Med J | pmid:14057706 |
| MORRIS B and SIMPSON-MORGAN MW | THE OXIDATION OF CONTINUOUSLY INFUSED CHYLOMICRON FATTY ACIDS BY UNANESTHETIZED RATS. | 1963 | J. Physiol. (Lond.) | pmid:14103556 |
| WAYS P et al. | RED-CELL AND PLASMA LIPIDS IN ACANTHOCYTOSIS. | 1963 | J. Clin. Invest. | pmid:14060400 |
| MOHRHAUER H and HOLMAN RT | EFFECT OF LINOLENIC ACID UPON THE METABOLISM OF LINOLEIC ACID. | 1963 | J. Nutr. | pmid:14061405 |
| IMAI H | STUDY BY ELECTRON MICROSCOPY OF OLEIC AND LINOLEIC ACIDS INJECTED INTRABRONCHIALLY INTO THE LUNGS OF RATS. | 1963 | Exp. Mol. Pathol. | pmid:14061852 |
| JAMESON E et al. | PROTECTION BY DIETARY FAT AFFORDED SERUM GAMMA 1-GLOBULIN OF X-IRRADIATED RATS. | 1963 | J. Nutr. | pmid:14062658 |
| WATSON WC | The morphology and lipid composition of the erythrocytes in normal and essential-fatty-acid-deficient rats. | 1963 | Br. J. Haematol. | pmid:13999227 |
| WOOD RD et al. | Metabolism of labeled linoleic-1-C-14 acid in the sheep rumen. | 1963 | J. Nutr. | pmid:14001756 |
| STEIN Y et al. | Enzymic pathways of glyceride and phospholipid synthesis in aortic homogenates. | 1963 | Biochim. Biophys. Acta | pmid:13983700 |
| HOMBURGER F et al. | Serum lipid changes accompanying the inclusion of canned fish in the diet. | 1963 | J Am Geriatr Soc | pmid:13961527 |
| BEELER DA and QUACKENBUSH FW | Effect of linoleate and dietary fat level on plasma and liver cholesterol and vascular lesions of the cholesterol-fed rat. | 1963 | J. Nutr. | pmid:13970237 |
| RAZIN S and ROTTEM S | FATTY ACID REQUIREMENTS OF MYCOPLASMA LAIDLAWII. | 1963 | J. Gen. Microbiol. | pmid:14114935 |
| ISSELBACHER KJ et al. | CONGENITAL BETA-LIPOPROTEIN DEFICIENCY: AN HEREDITARY DISORDER INVOLVING A DEFECT IN THE ABSORPTION AND TRANSPORT OF LIPIDS. | 1964 | Medicine (Baltimore) | pmid:14168744 |