| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chakrabarti KB et al. | Modification of doxorubicin-induced cardiotoxicity: effect of essential fatty acids and ICRF-187 (dexrazoxane). | 2001 | Eur. J. Cancer | pmid:11435077 |
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| Banni S et al. | Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. | 2001 | J. Lipid Res. | pmid:11441132 |
| Heydeck D et al. | Oxidation of LDL by rabbit and human 15-lipoxygenase: prevalence of nonenzymatic reactions. | 2001 | J. Lipid Res. | pmid:11441135 |
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| Almario RU et al. | Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. | 2001 | Am. J. Clin. Nutr. | pmid:11451720 |
| Whitehouse AS and Tisdale MJ | Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11453634 |
| Yu L | Free radical scavenging properties of conjugated linoleic acids. | 2001 | J. Agric. Food Chem. | pmid:11453790 |
| Thiel-Cooper RL et al. | Conjugated linoleic acid changes swine performance and carcass composition. | 2001 | J. Anim. Sci. | pmid:11465369 |
| Ramaswamy N et al. | Short communication: Consumer evaluation of milk high in conjugated linoleic acid. | 2001 | J. Dairy Sci. | pmid:11467809 |
| Sijben JW et al. | Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. | 2001 | Poult. Sci. | pmid:11469650 |
| Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. | 2001 | Am. J. Clin. Nutr. | pmid:11470727 |
| Kachhap SK et al. | Effect of omega-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line. | 2001 | Cancer Biother. Radiopharm. | pmid:11471489 |
| Malkowski MG et al. | Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. | 2001 | J. Biol. Chem. | pmid:11477109 |
| Spector AA | Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478370 |
| Gupta SV and Khosla P | Palmitic and stearic acids similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. | 2001 | J. Nutr. | pmid:11481404 |
| Phoon MC et al. | Linoleic and linolelaidic acids differentially influence proliferation and apoptosis of MOLT-4 leukaemia cells. | 2001 | Cell Biol. Int. | pmid:11482901 |
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| Chen ZY et al. | Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats. | 2001 | Br. J. Nutr. | pmid:11502239 |
| Chang W et al. | Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells. | 2001 | Mol. Cell. Biochem. | pmid:11506175 |
| Févrie P et al. | Separation of glyceride positional isomers by silver ion chromatography. | 2001 | J Chromatogr A | pmid:11510559 |
| Prescha A et al. | Increase in lipid content in potato tubers modified by 14-3-3 gene overexpression. | 2001 | J. Agric. Food Chem. | pmid:11513640 |
| Lin Y et al. | Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. | 2001 | Biochim. Biophys. Acta | pmid:11514234 |
| Pérez-Pé R et al. | Semen plasma proteins prevent cold-shock membrane damage to ram spermatozoa. | 2001 | Theriogenology | pmid:11516122 |
| Ramsay TG et al. | Dietary conjugated linoleic acid alters fatty acid composition of pig skeletal muscle and fat. | 2001 | J. Anim. Sci. | pmid:11518224 |
| Wiegand BR et al. | Conjugated linoleic acid improves feed efficiency, decreases subcutaneous fat, and improves certain aspects of meat quality in stress-genotype pigs. | 2001 | J. Anim. Sci. | pmid:11518228 |
| Kucuk O et al. | Effect of forage:concentrate ratio on ruminal digestion and duodenal flow of fatty acids in ewes. | 2001 | J. Anim. Sci. | pmid:11518234 |
| Abu-Ghazaleh AA et al. | Conjugated linoleic acid and other beneficial fatty acids in milk fat from cows fed soybean meal, fish meal, or both. | 2001 | J. Dairy Sci. | pmid:11518309 |
| Cubillos MA et al. | Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) dihydrochloride. | 2001 | Chem. Phys. Lipids | pmid:11518571 |
| Olsson U et al. | Changes in matrix proteoglycans induced by insulin and fatty acids in hepatic cells may contribute to dyslipidemia of insulin resistance. | 2001 | Diabetes | pmid:11522680 |
| Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
| Brown JM et al. | Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. | 2001 | J. Nutr. | pmid:11533273 |
| Bassaganya-Riera J et al. | Dietary conjugated linoleic acid modulates phenotype and effector functions of porcine CD8(+) lymphocytes. | 2001 | J. Nutr. | pmid:11533281 |
| McKay MC and Worley JF | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546665 |
| Kang K and Pariza MW | trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11554738 |
| Borecký J et al. | Functional reconstitution of Arabidopsis thaliana plant uncoupling mitochondrial protein (AtPUMP1) expressed in Escherichia coli. | 2001 | FEBS Lett. | pmid:11566183 |
| Gurvitz A et al. | Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. | 2001 | Biochim. Biophys. Acta | pmid:11566445 |
| Rainio A et al. | Reduction of linoleic acid inhibition in production of conjugated linoleic acid by Propionibacterium freudenreichii ssp. shermanii. | 2001 | Can. J. Microbiol. | pmid:11575500 |
| Kelly GS | Conjugated linoleic acid: a review. | 2001 | Altern Med Rev | pmid:11578253 |
| Poulos SP et al. | Pre- and postnatal dietary conjugated linoleic acid alters adipose development, body weight gain and body composition in Sprague-Dawley rats. | 2001 | J. Nutr. | pmid:11584096 |
| Costarelli V and Sanders TA | Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. | 2001 | Br. J. Nutr. | pmid:11591234 |
| Berthoud HR et al. | Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors. | 2001 | Brain Res. | pmid:11595203 |
| Bézaire V et al. | Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. | 2001 | Am. J. Physiol. Endocrinol. Metab. | pmid:11595653 |
| Ruiz-Sanz JI et al. | Polyunsaturated fatty acid deficiency during dietary treatment of very long-chain acyl-CoA dehydrogenase deficiency. Rescue with soybean oil. | 2001 | J. Inherit. Metab. Dis. | pmid:11596652 |
| Goffman FD and Böhme T | Relationship between fatty acid profile and vitamin E content in maize hybrids (Zea mays L.). | 2001 | J. Agric. Food Chem. | pmid:11600056 |
| Haastrup A et al. | Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. | 2001 | Hypertension | pmid:11641299 |
| Kozachenko AI et al. | Characteristics of beta-carotene-induced inhibition of free radical oxidation of fatty acids with different degree of unsaturation. | 2001 Jul-Aug | Dokl. Biochem. Biophys. | pmid:11665681 |
| Kolesnichenko AV et al. | Influence of CSP 310 and CSP 310-like proteins from cereals on mitochondrial energetic activity and lipid peroxidation in vitro and in vivo. | 2001 | BMC Plant Biol. | pmid:11667950 |
| Rahamatalla AB et al. | Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. | 2001 | Plant Foods Hum Nutr | pmid:11678443 |
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| López Bote CJ et al. | Effect of dietary linoleic acid concentration and vitamin E supplementation on cell desquamation and susceptibility to oxidative damage of pig jejunal mucosa. | 2001 | J Anim Physiol Anim Nutr (Berl) | pmid:11686769 |
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| De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
| Gwak HS and Chun IK | Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. | 2001 | Arch. Pharm. Res. | pmid:11794538 |
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| Kawajiri H et al. | Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. | 2002 | Arch. Biochem. Biophys. | pmid:11811948 |
| Mitchell LA et al. | Linoleic acid, cis-epoxyoctadecenoic acids, and dihydroxyoctadecadienoic acids are toxic to Sf-21 cells in the absence of albumin. | 2002 | Toxicol. Lett. | pmid:11814707 |