Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Grech ED et al. Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. 1993 Coron. Artery Dis. pmid:8287210
Hrboticky N et al. Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. 1994 J. Clin. Invest. pmid:8282787
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
Bronstein JC and Bull AW The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. 1993 Prostaglandins pmid:8278616
Lamb RG et al. An in vitro model of ethanol-dependent liver cell injury. 1994 Hepatology pmid:8276354
Ettinger WH et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. 1994 Arterioscler. Thromb. pmid:8274481
Dehaut F et al. n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. 1993 Neurosci. Lett. pmid:8272254
Sullivan JL et al. Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. 1993 J. Dairy Sci. pmid:8270698
Blee E et al. Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. 1993 Biochem. Biophys. Res. Commun. pmid:8267615
Whelan J et al. Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters. 1993 J. Nutr. pmid:8263613
Viola G et al. Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. 1993 J. Lipid Res. pmid:8263409
Jones AL et al. Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. 1993 Biochem. J. pmid:8250841
Vargas F et al. Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. 1993 Photochem. Photobiol. pmid:8248320
Darmani H et al. Interferon-gamma-stimulated uptake and turnover of linoleate and arachidonate in macrophages: a possible pathway for hypersensitivity to endotoxin. 1993 Cell. Immunol. pmid:8242772
Biagi PL et al. Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. 1993 Acta Paediatr. pmid:8241678
Markovic DZ and Patterson LK Benzophenone-sensitized lipid peroxidation in linoleate micelles. 1993 Photochem. Photobiol. pmid:8234464
Daret D et al. Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. 1993 J. Lipid Res. pmid:8228632
de Deckere EA et al. Hepatic de novo fatty acid synthesis in the rat. 1993 Ann. Nutr. Metab. pmid:8215236
Viscardi RM and Max SR Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells. 1993 Steroids pmid:8212085
Sakuma S et al. Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. 1993 Prostaglandins pmid:8210445
Grammatopoulos D et al. The human myometrial CRH receptor: G proteins and second messengers. 1994 Mol. Cell. Endocrinol. pmid:8206332
Glasgow WC and Eling TE Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. 1994 Arch. Biochem. Biophys. pmid:8203891
Yamashiro Y et al. Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. 1994 J. Pediatr. Surg. pmid:8201513
Andrassy RJ et al. Linoleic acid enhances mitogen response and survival of septic weanling rats. 1994 J. Pediatr. Surg. pmid:8201499
Truswell AS Can linoleic acid contribute to coronary artery disease? 1994 Am. J. Clin. Nutr. pmid:8198070
Hodgson JM et al. Can linoleic acid contribute to coronary artery disease? 1993 Am. J. Clin. Nutr. pmid:8192728
Cronan JE and Rock CO The presence of linoleic acid in Escherichia coli cannot be confirmed. 1994 J. Bacteriol. pmid:8188608
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Jakobsen K et al. Heat production and quantitative oxidation of nutrients by physical activity in pigs. 1994 Ann. Nutr. Metab. pmid:8185282
Appel MJ et al. Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. 1994 Cancer Res. pmid:8174115
Cho Y and Ziboh VA Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. 1994 J. Lipid Res. pmid:8169529
Fuchs GJ et al. Effect of dietary fat on cardiovascular risk factors in infancy. 1994 Pediatrics pmid:8165074
Araki K et al. Reduced cytotoxicity of a root canal sealer through eugenol substitution. 1993 J Endod pmid:8151243
Kanekal S and Kehrer JP Metabolism of cyclophosphamide by lipoxygenases. 1994 Jan-Feb Drug Metab. Dispos. pmid:8149893
Reaven PD et al. Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. 1994 Arterioscler. Thromb. pmid:8148354
Jenkins TC et al. Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. 1994 J. Nutr. pmid:8145079
Paiement J et al. Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. 1994 Biochim. Biophys. Acta pmid:8142417
Shiina T et al. Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. 1993 Atherosclerosis pmid:8141854
Calder PC et al. Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. 1994 Biochem. J. pmid:8141773
Ip C et al. Potential of food modification in cancer prevention. 1994 Cancer Res. pmid:8137319
Chopra M et al. Free radical scavenging of lutein in vitro. 1993 Ann. N. Y. Acad. Sci. pmid:8129303
Castell JV et al. Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. 1994 Photochem. Photobiol. pmid:8127938
Rao SI et al. The lipoxygenase activity of myoglobin. Oxidation of linoleic acid by the ferryl oxygen rather than protein radical. 1994 J. Biol. Chem. pmid:8125933
Liu XH and Rose DP Stimulation of type IV collagenase expression by linoleic acid in a metastatic human breast cancer cell line. 1994 Cancer Lett. pmid:8124668
Schürer NY et al. Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line. 1994 Biochim. Biophys. Acta pmid:8123682
Hernández-Muñoz I et al. Toxic oil stimulates collagen synthesis acting at a pretranslational level in cultured fat-storing cells. 1994 Gastroenterology pmid:8119541
Loidl-Stahlhofen A and Spiteller G alpha-Hydroxyaldehydes, products of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8117742
Hamberg M et al. Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. 1994 Arch. Biochem. Biophys. pmid:8117115
DeWille JW and Farmer SJ Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. 1993 Biochim. Biophys. Acta pmid:8105893
Spady DK Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. 1993 J. Lipid Res. pmid:8105015
Shichiri G et al. Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. 1993 Arch. Biochem. Biophys. pmid:8099780
Asaoka Y et al. Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8099446
Nakashima Y et al. Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice. 1993 J. Lipid Res. pmid:8094090
Denizot Y et al. Stimulated human gastric tumor cells (HGT) fail to synthesize eicosanoids. 1994 Cancer Lett. pmid:8076375
Jensen MM et al. Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. 1994 Ann. Nutr. Metab. pmid:8067685
Siguel EN and Lerman RH Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. 1994 Metab. Clin. Exp. pmid:8052156
Hoving EB et al. Gestational age dependency of essential fatty acids in cord plasma cholesterol esters and triglycerides. 1994 Pediatr. Res. pmid:8047383
Grabski S et al. Lipids trigger changes in the elasticity of the cytoskeleton in plant cells: a cell optical displacement assay for live cell measurements. 1994 J. Cell Biol. pmid:8045935
Kliewer SA et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8041794
Imokawa G et al. Pseudo-acylceramide with linoleic acid produces selective recovery of diminished cutaneous barrier function in essential fatty acid-deficient rats and has an inhibitory effect on epidermal hyperplasia. 1994 J. Clin. Invest. pmid:8040295
Batna A and Spiteller G Oxidation of furan fatty acids by soybean lipoxygenase-1 in the presence of linoleic acid. 1994 Chem. Phys. Lipids pmid:8033289
Kaufman MJ Comparison of the free radical-scavenging ability of captopril and ascorbic acid in an in-vitro model of lipid oxidation. Implications for reperfusion injury and ACE inhibitor therapy. 1994 J. Pharm. Pharmacol. pmid:8027931
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Hussey HJ and Tisdale MJ Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo. 1994 Br. J. Cancer pmid:8018542
Woldseth B and Christophersen BO Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. 1994 Biochim. Biophys. Acta pmid:8011678
Luthria DL and Sprecher H A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. 1994 Biochim. Biophys. Acta pmid:8011670
Nowak D et al. Antioxidant properties of Ambroxol. 1994 Free Radic. Biol. Med. pmid:8005537
Jack CI et al. Serum octadeca-9,11 dienoic acid--an assay of free radical activity or a result of bacterial production? 1994 Clin. Chim. Acta pmid:8004784
Simopoulos AP Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? 1994 Free Radic. Biol. Med. pmid:8001841
Lafond J et al. Linoleic acid transport by human placental syncytiotrophoblast membranes. 1994 Eur. J. Biochem. pmid:8001588
Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Babizhayev MA et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. 1994 Biochem. J. pmid:7998987
Pourplanche C et al. Conformational changes of lipoxygenase (LOX) in modified environments. Contribution to the variation in specificity of soybean LOX type 1. 1994 J. Biol. Chem. pmid:7989328
Rose DP et al. Effects of linoleic acid on the growth and metastasis of two human breast cancer cell lines in nude mice and the invasive capacity of these cell lines in vitro. 1994 Cancer Res. pmid:7987856
Kasayama S et al. Unsaturated fatty acids are required for continuous proliferation of transformed androgen-dependent cells by fibroblast growth factor family proteins. 1994 Cancer Res. pmid:7987840
Yam D et al. Insulin and glucose status, tissue and plasma lipids in patients with tumours of the ovary or endometrium: possible dietary implications. 1994 Br. J. Cancer pmid:7981074
Lee KN et al. Conjugated linoleic acid and atherosclerosis in rabbits. 1994 Atherosclerosis pmid:7980704
Ohrvall M et al. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. 1994 Atherosclerosis pmid:7980703
Soltysova T and Bellisle F Nutrition in ten-year-old children of the Liberec area (Czech Republic). 1994 Ann. Nutr. Metab. pmid:7979168
Taylor AJ Erythrocyte membrane fatty acid composition in hypercholesterolaemia. 1994 Ann. Clin. Biochem. pmid:7979101
Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
Hopewell JW et al. Amelioration of both early and late radiation-induced damage to pig skin by essential fatty acids. 1994 Int. J. Radiat. Oncol. Biol. Phys. pmid:7961020
Pronczuk A et al. Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. 1994 FASEB J. pmid:7958627
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
Eder K and Kirchgessner M Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. 1994 J. Nutr. pmid:7931700
Richieri GV et al. Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. 1994 J. Biol. Chem. pmid:7929039
del Carmen Boyano-Adánez M et al. Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. 1994 Biochim. Biophys. Acta pmid:7918608
Bakken AM et al. The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. 1994 Biochim. Biophys. Acta pmid:7918598
Roy P et al. Superoxide generation by lipoxygenase in the presence of NADH and NADPH. 1994 Biochim. Biophys. Acta pmid:7918597
van Kuiken BA and Behnke WD The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. 1994 Biochim. Biophys. Acta pmid:7918595
Watanabe S et al. A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. 1994 J. Nutr. pmid:7916376
Ulmann L et al. Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. 1994 Biochim. Biophys. Acta pmid:7915142
Sacks GS et al. Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. 1994 May-Jun JPEN J Parenter Enteral Nutr pmid:7914941
Yang J et al. Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. 1994 Metab. Clin. Exp. pmid:7914345
Emken EA et al. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. 1994 Biochim. Biophys. Acta pmid:7914092
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Yang X and Dick TA Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). 1994 J. Nutr. pmid:7913126
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Okuley J et al. Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. 1994 Plant Cell pmid:7907506
Regdel D et al. On the reaction specificity of the lipoxygenase from tomato fruits. 1994 Biochim. Biophys. Acta pmid:7905748