| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yen GC and Chuang DY | Antioxidant properties of water extracts from Cassia tora L. in relation to the degree of roasting. | 2000 | J. Agric. Food Chem. | pmid:10898619 |
| Mizushina Y et al. | Mode analysis of binding of fatty acids to mammalian DNA polymerases. | 2000 | Biochim. Biophys. Acta | pmid:10903472 |
| Deva R et al. | Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. | 2000 | Biochim. Biophys. Acta | pmid:10903481 |
| Groussard C et al. | Free radical scavenging and antioxidant effects of lactate ion: an in vitro study. | 2000 | J. Appl. Physiol. | pmid:10904049 |
| O'Shea M et al. | The effect of a conjugated dienoic derivative of linoleic acid on the in vitro growth of MCF-7 and SW480 human cancer cell lines. | 1998 | Biochem. Soc. Trans. | pmid:10909819 |
| Cantwell H et al. | The effect of a conjugated linoleic acid on superoxide dismutase, catalase and glutathione peroxidase in oxidatively-challenged liver cells. | 1998 | Biochem. Soc. Trans. | pmid:10909820 |
| Wenger FA et al. | Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913224 |
| Sakurada K et al. | cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10913372 |
| Vanella A et al. | L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. | 2000 | Cell Biol. Toxicol. | pmid:10917565 |
| Jones S et al. | Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens. | 2000 | J. Nutr. | pmid:10917915 |
| Kamlage B et al. | Linoleic acid conjugation by human intestinal microorganisms is inhibited by glucose and other substrates in vitro and in gnotobiotic rats. | 2000 | J. Nutr. | pmid:10917922 |
| Viola G et al. | In vitro studies of the phototoxic potential of the antidepressant drugs amitriptyline and imipramine. | 2000 | Farmaco | pmid:10919085 |
| Ip C et al. | Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland. | 2000 | Cancer Epidemiol. Biomarkers Prev. | pmid:10919739 |
| Rosella O et al. | Polyunsaturated fatty acids reduce non-receptor-mediated transcellular permeation of protein across a model of intestinal epithelium in vitro. | 2000 | J. Gastroenterol. Hepatol. | pmid:10921416 |
| Dilika F et al. | Antibacterial activity of linoleic and oleic acids isolated from Helichrysum pedunculatum: a plant used during circumcision rites. | 2000 | Fitoterapia | pmid:10925024 |
| Wingler K et al. | Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. | 2000 | Gastroenterology | pmid:10930377 |
| Kotani A et al. | Determination of plasma free fatty acids by high-performance liquid chromatography with electrochemical detection. | 2000 | Anal. Biochem. | pmid:10933857 |
| Zusman I et al. | Transplacental effects of maternal feeding with high fat diets on lipid exchange and response of the splenic lymphoid system in mice offspring exposed to low doses of carcinogen. | 2000 | Int. J. Mol. Med. | pmid:10934300 |
| Meilhac O et al. | Lipid peroxides induce expression of catalase in cultured vascular cells. | 2000 | J. Lipid Res. | pmid:10946007 |
| Magsino CH et al. | Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. | 2000 | Am. J. Cardiol. | pmid:10946040 |
| Yang M et al. | Dietary conjugated linoleic acid protects against end stage disease of systemic lupus erythematosus in the NZB/W F1 mouse. | 2000 | Immunopharmacol Immunotoxicol | pmid:10946824 |
| Sijben JW et al. | Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. | 2000 | Poult. Sci. | pmid:10947178 |
| Kritchevsky D | Antimutagenic and some other effects of conjugated linoleic acid. | 2000 | Br. J. Nutr. | pmid:10953669 |
| Hennig B et al. | Fatty acid-mediated activation of vascular endothelial cells. | 2000 | Metab. Clin. Exp. | pmid:10954018 |
| Yang L et al. | Oxidative stability of conjugated linoleic acid isomers. | 2000 | J. Agric. Food Chem. | pmid:10956070 |
| Griinari JM et al. | Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase. | 2000 | J. Nutr. | pmid:10958825 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. | 2000 | Am. J. Clin. Nutr. | pmid:10966889 |
| Moosmann B and Behl C | Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins. | 2000 | Eur. J. Biochem. | pmid:10971578 |
| Monteggia E et al. | Phospholipid distribution in murine mammary adenocarcinomas induced by activated neu oncogene. | 2000 | Cancer Detect. Prev. | pmid:10975281 |
| Kajita M et al. | Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. | 2000 | J Pharm Sci | pmid:10980499 |
| Oak J et al. | Synthetically prepared Aamadori-glycated phosphatidylethanolaminecan trigger lipid peroxidation via free radical reactions. | 2000 | FEBS Lett. | pmid:10984609 |
| O'Quinn PR et al. | Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs. | 2000 | J. Anim. Sci. | pmid:10985411 |
| Hover CG and Kulkarni AP | Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid. | 2000 | Placenta | pmid:10985967 |
| Meinelt T et al. | Correlation of diets high in n-6 polyunsaturated fatty acids with high growth rate in zebrafish (Danio rerio). | 2000 | Comp. Med. | pmid:10987667 |
| Simopoulos AP | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991765 |
| Galli C | Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991767 |
| Crawford MA | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991768 |
| Cunnane SC | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991770 |
| Horrobin DF | Commentary on the workshop statement: are we really sure that arachidonic acid and linoleic acid are bad things? | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991771 |
| Kim SJ et al. | Improvement of oxidative stability of conjugated linoleic acid (CLA) by microencapsulation in cyclodextrins. | 2000 | J. Agric. Food Chem. | pmid:10995292 |
| Antony SM et al. | Antioxidative effect of maillard reaction products formed from honey at different reaction times. | 2000 | J. Agric. Food Chem. | pmid:10995301 |
| Livisay SA et al. | Impact of dietary conjugated linoleic acid on the oxidative stability of rat liver microsomes and skeletal muscle homogenates. | 2000 | J. Agric. Food Chem. | pmid:10995331 |
| Han KH et al. | Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. | 2000 | J. Clin. Invest. | pmid:10995790 |
| Schaffrath U et al. | Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators. | 2000 | Eur. J. Biochem. | pmid:10998053 |
| Jones DF et al. | Short communication: influence of dietary tallow and fish oil on milk fat composition. | 2000 | J. Dairy Sci. | pmid:11003234 |
| Sol Morales M et al. | Milk fat composition of Holstein and Jersey cows with control or depleted copper status and fed whole soybeans or tallow. | 2000 | J. Dairy Sci. | pmid:11003245 |
| DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
| Lucchi L et al. | Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure. | 2000 | Kidney Int. | pmid:11012903 |
| Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
| West DB et al. | Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. | 2000 | J. Nutr. | pmid:11015475 |