Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Sohal RS et al. Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. 1984 Mech. Ageing Dev. pmid:6330462
Sakaguchi M et al. Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. 1984 Cancer Res. pmid:6704963
Van Alstine JM and Brooks DE Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. 1984 Clin. Chem. pmid:6199135
Benaim G et al. Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. 1984 J. Biol. Chem. pmid:6234313
Grossman S et al. Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. 1984 Biochim. Biophys. Acta pmid:6424722
Kitagawa S et al. Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. 1984 Biochim. Biophys. Acta pmid:6324876
Simon I et al. Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. 1984 Biochim. Biophys. Acta pmid:6326852
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Inouye S Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. 1984 FEBS Lett. pmid:6430718
Ramesha CS and Thompson GA The mechanism of membrane response to chilling. Effect of temperature on phospholipid deacylation and reacylation reactions in the cell surface membrane. 1984 J. Biol. Chem. pmid:6430890
Neufeld EJ et al. A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. 1984 J. Biol. Chem. pmid:6420417
Heine RJ et al. The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. 1984 Ann. Nutr. Metab. pmid:6476785
Badwey JA et al. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. 1984 J. Biol. Chem. pmid:6330088
Arslan P et al. cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. 1984 Biochem. J. pmid:6696740
Alao SJ and Balnave D Growth and carcass composition of broilers fed sunflower oil and olive oil. 1984 Br. Poult. Sci. pmid:6733552
Stymne S and Stobart AK The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). 1984 Biochem. J. pmid:6743281
Colard O et al. 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver. 1984 Biochimie pmid:6743697
Cunnane SC et al. Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. 1984 Br. J. Nutr. pmid:6422980
Harada H et al. Enhanced suppression of myocardial slow action potentials during hypoxia by free fatty acids. 1984 J. Mol. Cell. Cardiol. pmid:6716492
McMurchie EJ et al. Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. 1984 Am. J. Clin. Nutr. pmid:6720626
Iversen SA et al. Identification of a diene conjugated component of human lipid as octadeca-9,11-dienoic acid. 1984 FEBS Lett. pmid:6723989
Schafer E and Arnrich L Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. 1984 J. Nutr. pmid:6726476
Singer P et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. 1984 Prostaglandins pmid:6328578
Hennig B et al. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. 1984 Sep-Oct Arteriosclerosis pmid:6477300
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. 1985 J. Biol. Chem. pmid:3934168
O'Brien PM et al. The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? 1985 Br J Clin Pharmacol pmid:2985102
Salafsky B and Fusco AC Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen. 1985 Exp. Parasitol. pmid:2990990
Kharasch ED and Novak RF Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. 1985 J. Biol. Chem. pmid:2993283
Claeys M et al. Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. 1985 Biochim. Biophys. Acta pmid:2996610
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Hansen HS and Jensen B Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. 1985 Biochim. Biophys. Acta pmid:3922424
Nugteren DH et al. Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. 1985 Biochim. Biophys. Acta pmid:3922425
Margetts BM et al. Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. 1985 Clin. Sci. pmid:3905211
Ip C et al. Requirement of essential fatty acid for mammary tumorigenesis in the rat. 1985 Cancer Res. pmid:3921234
Calderbank J et al. Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. 1985 J. Gen. Microbiol. pmid:3886834
Canfield LM et al. Anti-oxidant/pro-oxidant reactions of vitamin K. 1985 Biochem. Biophys. Res. Commun. pmid:3985964
Válek J et al. Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. 1985 Atherosclerosis pmid:3994777
Tsuchida M et al. Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. 1985 Biochim. Biophys. Acta pmid:3995061
Bowser PA et al. Identification, isolation and characterization of epidermal lipids containing linoleic acid. 1985 Biochim. Biophys. Acta pmid:3995076
Demant EJ and Wassermann K Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. 1985 Biochem. Pharmacol. pmid:4004891
Robinson M et al. Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. 1985 J. Biol. Chem. pmid:4008481
Howard-Williams J et al. Polyunsaturated fatty acids and diabetic retinopathy. 1985 Br J Ophthalmol pmid:3965024
Montalto MB et al. Nutrient intakes of formula-fed infants and infants fed cow's milk. 1985 Pediatrics pmid:3969338
Reid JC and Husbands DR Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. 1985 Biochem. J. pmid:3977825
Jett M et al. Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. 1985 Cancer Res. pmid:4027970
Roshanai F and Sanders TA Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4037727
Becker W and MÃ¥nsson JE Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. 1985 J. Nutr. pmid:4045568
Charnock JS et al. Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4051450
Charnock JS et al. Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. 1985 Ann. Nutr. Metab. pmid:4051452
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
Hennig B et al. Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. 1985 Circ. Res. pmid:4053308
Barclay LR et al. The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. 1985 J. Biol. Chem. pmid:4066696
Potter LM and McCarthy JP Varying fat and protein in diets of growing large white turkeys. 1985 Poult. Sci. pmid:4070128
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Isseroff RR et al. Alterations in fatty acid composition of murine keratinocytes with in vitro cultivation. 1985 J. Invest. Dermatol. pmid:3926903
Giamalva D et al. A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. 1985 Biochem. Biophys. Res. Commun. pmid:4084297
Wertz PW et al. The composition of the ceramides from human stratum corneum and from comedones. 1985 J. Invest. Dermatol. pmid:3158712
Rebello T and Watts DC Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. 1985 J. Neurochem. pmid:3158720
Pascaud M and Strouve-Vallet C Desaturation of 14C linoleic acid by the rat fetus. 1985 Ann. Nutr. Metab. pmid:2983600
Nordøy A et al. Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. 1985 Biochim. Biophys. Acta pmid:2861854
Fusco AC et al. Schistosoma mansoni: eicosanoid production by cercariae. 1985 Exp. Parasitol. pmid:3917929
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Farrell PM et al. Fatty acid abnormalities in cystic fibrosis. 1985 Pediatr. Res. pmid:3918287
Cooke RJ et al. Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. 1985 J. Pediatr. Gastroenterol. Nutr. pmid:3930688
Smith MT and Thompson S Free radicals and alcoholics. 1985 Lancet pmid:2864501
Stoeck M et al. Studies on the mechanism whereby cyclosporin A inhibits T-lymphocyte activation. 1985 Immunobiology pmid:2580777
Boberg M et al. Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. 1985 Clin. Sci. pmid:3919990
Erskine KJ et al. An altered ratio of 18:2 (9,11) to 18:2 (9,12) linoleic acid in plasma phospholipids as a possible predictor of pre-eclampsia. 1985 Lancet pmid:2857904
Fink R et al. Increased free-radical activity in alcoholics. 1985 Lancet pmid:2862465
Banerjee N and Rosenthal MD High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. 1985 Biochim. Biophys. Acta pmid:2990563
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
Salzmann-Reinhardt U et al. Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. 1985 Eur. J. Biochem. pmid:3933978
Burton AF and Anderson FH Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. 1985 Jul-Aug JPEN J Parenter Enteral Nutr pmid:3839859
Andersen GE et al. Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants. 1985 Nov-Dec JPEN J Parenter Enteral Nutr pmid:3934403
Nanji AA and Narod S Multiple sclerosis, latitude and dietary fat: is pork the missing link? 1986 Med. Hypotheses pmid:3638477
Boberg M et al. High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. 1986 Eur. J. Clin. Invest. pmid:2938965
May V and Eipper BA Long term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. 1986 Endocrinology pmid:3004908
Yamamoto T et al. Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. 1986 Biochim. Biophys. Acta pmid:3015226
Youyou A et al. Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. 1986 J. Neurochem. pmid:3940283
Nijssen JG and van den Bosch H Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3947653
Kryvi H et al. Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. 1986 Biochim. Biophys. Acta pmid:3947675
Ishiura S et al. Reticulocyte lipoxygenase, ingensin, and ATP-dependent proteolysis. 1986 FEBS Lett. pmid:3086125
Beneytout JL et al. Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. 1986 Prostaglandins pmid:3086939
Riemersma RA et al. Linoleic acid content in adipose tissue and coronary heart disease. 1986 Br Med J (Clin Res Ed) pmid:3087455
Hansen HS et al. Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. 1986 Biochim. Biophys. Acta pmid:3092868
Chambaz J et al. Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3092869
Kanofsky JR and Axelrod B Singlet oxygen production by soybean lipoxygenase isozymes. 1986 J. Biol. Chem. pmid:3080416
Renner F et al. Effect of saturated and unsaturated lipid on the composition of mesenteric triglyceride-rich lipoproteins in the rat. 1986 J. Lipid Res. pmid:3083032
Kanazawa K et al. The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. 1986 Biochim. Biophys. Acta pmid:3768385
Jensen GE and Clausen J Glutathione peroxidase activity, associated enzymes and substrates in blood cells from patients with multiple sclerosis--effects of antioxidant supplementation. 1986 Acta Pharmacol Toxicol (Copenh) pmid:3776606
Hennig B et al. Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. 1986 Arch. Biochem. Biophys. pmid:3729421
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
Utermohlen V and Tucker MA Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. 1986 Proc Nutr Soc pmid:3797410
Hansen HS and Jensen B Urinary excretion of arginine-vasopressin and prostaglandin E2 in essential fatty acid-deficient rats after oral supplementation with unsaturated fatty acid esters. 1986 J. Nutr. pmid:3080561
Okabe H et al. Effects of anti-convulsants on fatty acid metabolism in human serum. 1986 Tohoku J. Exp. Med. pmid:3705068
Nijssen JG and van den Bosch H Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3081034
Lee SH and Clandinin MT Effect of dietary fat on the utilization of fatty acids by myocardial tissue in the rat. 1986 J. Nutr. pmid:3794820
Morson LA and Clandinin MT Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. 1986 J. Nutr. pmid:2879899
Andre JC and Funk MO Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. 1986 Anal. Biochem. pmid:3101541
Siegel I et al. Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. 1986 Fertil. Steril. pmid:2868925